ArticleCells2020
Neutrophil Extracellular Traps Promote the Development and Growth of Human Salivary Stones.
Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
33 citing papers in PubMed, 45 citations in OpenAlex.
- Nucleic Acids as Emerging Regulators of Calcium Phosphate Biomineralization.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- A Case Report of Eosinophilic Sialodochitis with Right Submandibular Sialolithiasis and Hyperattenuating Material Along Wharton's Duct.Reports (MDPI) · 2026Article
- Neutrophil Extracellular Traps Promote the Formation of Canine Dental Calculus.Veterinary sciences · 2026Article
- Identifying Risk Factors for Sialolithiasis.The Laryngoscope · 2026Article
- Neutrophil extracellular traps drive peritoneal inflammation and tissue remodeling in pediatric peritoneal dialysis.Pediatric nephrology (Berlin, Germany) · 2026Article
- Corticosteroid irrigation of parotid glands for oral dryness in Sjögren's and non-Sjögren's sicca disease: a longitudinal study.Clinical rheumatology · 2025Article
- Spontaneous Expulsion and Compositional Analysis by Infrared Spectroscopy of a Parotid Sialolith: A Case Report.EJIFCC · 2025Article
- Protein expression of sialolith with antrolith and tonsillolith examined by immunohistochemistry and immunoprecipitation based high performance liquid chromatography.Scientific reports · 2025Article
- Immunomodulation of salivary gland function due to cancer therapy.Oral diseases · 2025Review
- Effects of calcium oxalate crystals on neutrophil cellular proteome and functions: implications for nephrolithiasis.Cell communication and signaling : CCS · 2025Article
- Comorbidity Patterns Among Patients Diagnosed with Sialolithiasis: A Retrospective Analysis.Journal of clinical medicine · 2025Article
- Surgical non-aggressive approach for the delivery of 4 cm salivary stone from the submandibular gland duct: Avoiding salivary gland removal - A case report.International journal of surgery case reports · 2025Article
- Neutrophil Extracellular Traps as a Biomarker in Refractory Non-Type 2 CRSwNP.Allergy, asthma & immunology research · 2024Article
- Bacteria-mediated resistance of neutrophil extracellular traps to enzymatic degradation drives the formation of dental calculi.Nature biomedical engineering · 2024Article
- Recent advances in the pathogenesis and prevention strategies of dental calculus.NPJ biofilms and microbiomes · 2024Review
- Elemental characteristics of sialoliths extracted from a patient with recurrent sialolithiasis.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2024Article
- Association of neutrophil defects with oral ulcers but undetermined role of neutrophils in recurrent aphthous stomatitis.Heliyon · 2024Review
- Layered structure of sialoliths compared with tonsilloliths and antroliths.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2024Article
- Identification of biological components for sialolith formation organized in circular multi-layers.Scientific reports · 2023Article
- Article
Corrections and comments
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Authors and funding
17 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salivary gland stones, or sialoliths, are the most common cause of the obstruction of salivary glands. The mechanism behind the formation of sialoliths has been elusive. Symptomatic sialolithiasis has a prevalence of 0.45% in the general population, is characterized by recurrent painful periprandial swelling of the affected gland, and often results in sialadenitis with the need for surgical intervention. Here, we show by the use of immunohistochemistry, immunofluorescence, computed tomography (CT) scans and reconstructions, special dye techniques, bacterial genotyping, and enzyme activity analyses that neutrophil extracellular traps (NETs) initiate the formation and growth of sialoliths in humans. The deposition of neutrophil granulocyte extracellular DNA around small crystals results in the dense aggregation of the latter, and the subsequent mineralization creates alternating layers of dense mineral, which are predominantly calcium salt deposits and DNA. The further agglomeration and appositional growth of these structures promotes the development of macroscopic sialoliths that finally occlude the efferent ducts of the salivary glands, causing clinical symptoms and salivary gland dysfunction. These findings provide an entirely novel insight into the mechanism of sialolithogenesis, in which an immune system-mediated response essentially participates in the physicochemical process of concrement formation and growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.