Evidence map›Paper›PMID 32971741›Full record

ArticleCancers2020

Deregulated microRNAs Are Associated with Patient Survival and Predicted to Target Genes That Modulate Lung Cancer Signaling Pathways.

Cristiano P Souza, Naiara C Cinegaglia, Tainara F Felix, Adriane F Evangelista, Rogério A Oliveira, Erica N Hasimoto, Daniele C Cataneo, Antônio J M Cataneo, Cristovam Scapulatempo Neto, Cristiano R Viana and 6 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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  3. Article
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  5. Article
  6. Cell Behavior of Non-Small Cell Lung Cancer Is at EGFR and MicroRNAs Hands.International journal of molecular sciences · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Cristiano P SouzaDepartment of Surgery and Orthopedics, Faculty of Medicine, São Paulo State University, UNESP, Botucatu 18618-687, SP, Brazil.
Naiara C CinegagliaExperimental Research Unity (UNIPEX), São Paulo State University, UNESP, Botucatu 18618-687, SP, Brazil.
Tainara F FelixExperimental Research Unity (UNIPEX), São Paulo State University, UNESP, Botucatu 18618-687, SP, Brazil.
Adriane F EvangelistaMolecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, SP, Brazil.ORCID 0000-0002-4731-2082
Rogério A OliveiraDepartment of Biostatistics, Plant Biology, Parasitology, and Zoology, Institute of Biosciences, São Paulo State University UNESP, Botucatu 18618-689, SP, Brazil.ORCID 0000-0002-7568-748X
Erica N HasimotoDepartment of Surgery and Orthopedics, Faculty of Medicine, São Paulo State University, UNESP, Botucatu 18618-687, SP, Brazil.
Daniele C CataneoDepartment of Surgery and Orthopedics, Faculty of Medicine, São Paulo State University, UNESP, Botucatu 18618-687, SP, Brazil.ORCID 0000-0002-3400-2309
Antônio J M CataneoDepartment of Surgery and Orthopedics, Faculty of Medicine, São Paulo State University, UNESP, Botucatu 18618-687, SP, Brazil.ORCID 0000-0003-2330-9337
Cristovam Scapulatempo NetoMolecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, SP, Brazil.
Cristiano R VianaMolecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, SP, Brazil.
Flávia E de PaulaMolecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, SP, Brazil.
Sandra A DrigoDepartment of Surgery and Orthopedics, Faculty of Medicine, São Paulo State University, UNESP, Botucatu 18618-687, SP, Brazil.ORCID 0000-0001-6747-6642
Robson F CarvalhoDepartment of Structural and Functional Biology, Institute of Biosciences, São Paulo State University, UNESP, Botucatu 18618-689, SP, Brazil.ORCID 0000-0002-4901-7714
Márcia M C MarquesMolecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, SP, Brazil.
Rui M ReisMolecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, SP, Brazil.ORCID 0000-0002-9639-7940
Patricia P ReisDepartment of Surgery and Orthopedics, Faculty of Medicine, São Paulo State University, UNESP, Botucatu 18618-687, SP, Brazil.ORCID 0000-0003-3775-3797
Hospital de Câncer de Barretos · BRUniversidade Estadual Paulista (Unesp) · BRCentro Universitário de João Pessoa · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2011/13213-7
6 · The paper itself

Abstract

(1) Background: Although the advances in diagnostic and treatment strategies, lung cancer remains the leading cause of cancer-related deaths, worldwide, with survival rates as low as 16% in developed countries. Low survival rates are mainly due to late diagnosis and the lack of effective treatment. Therefore, the identification of novel, clinically useful biomarkers is still needed for patients with advanced disease stage and poor survival. Micro(mi)RNAs are non-coding RNAs and potent regulators of gene expression with a possible role as diagnostic, prognostic and predictive biomarkers in cancer. (2) Methods: We applied global miRNA expression profiling analysis using TaqMan

Indexed as

lung cancermicroRNAspathwayssurvivaltarget genes

Identifiers

PMID32971741
PMCPMC7563870
OpenAlexW3087265259

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.