ArticleNature2020
Integration of innate immune signalling by caspase-8 cleavage of N4BP1.
Abstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 111 citations in OpenAlex.
- N4BP1 uses tandem KH domains to associate with EDC4 and mRNA decapping factors in P-bodies.Communications biology · 2026Article
- cFLIP suppresses caspase-1- and MLKL-independent perinatal lethality driven by auto-processing impaired caspase-8 D387A.Cell death and differentiation · 2026Article
- Mapping the holonomic signaling network that drives pathological changes in endotoxic shock.Cellular & molecular immunology · 2026Article
- Fas acts as a T cell co-stimulatory receptor via both death domain-independent and -dependent mechanisms.Cell death and differentiation · 2026Article
- Caspase-8-mediated CYLD cleavage boosts LPS-induced endotoxic shock.Cell death and differentiation · 2026Article
- Caspase-8 comes in from the CYLD.Cell death and differentiation · 2026Article
- Poxvirus attack of antiviral defense pathways unleashes an effector-triggered NF-κB response.Science (New York, N.Y.) · 2026Article
- N4BP1 is essential for the development of oral cancer via controlling both cancer cells and immune microenvironment.Cell death & disease · 2026Article
- N4BP1 acts as a potent negative regulator of IL-17 signaling by blocking the translation of Act1 mRNA.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- The role of HECT-type E3 ubiquitin ligases in inflammation.Frontiers in immunology · 2026Review
- Altered expression of ADAR1, N4BP1, and PSME1 in PBMCs correlated with therapeutic outcomes in HBeAg-negative chronic hepatitis B patients treated with Peg-IFN-α.Frontiers in cellular and infection microbiology · 2026Observational
- Monogenic disorders of the TNF signalling pathway.Nature reviews. Rheumatology · 2026Review
- KHNYN is a manganese-dependent endoribonuclease required for ZAP-mediated antiviral restriction.Nucleic acids research · 2025Article
- Non-apoptotic caspase-8 is critical for orchestrating exaggerated inflammation during severe SARS-CoV-2 infection.Nature communications · 2025Article
- Regulation of inflammatory processes by caspases.Nature reviews. Molecular cell biology · 2025Review
- Innate immune sensing and signaling: Co-opted for genome surveillance? Implications for tumorigenesis.DNA repair · 2025Review
- FLIPProceedings of the National Academy of Sciences of the United States of America · 2025Article
- NEDD4-binding protein 1 suppresses hepatitis B virus replication by regulating viral RNAs.The Journal of general virology · 2025Article
- Enteroviral 3C protease cleaves N4BP1 to impair the host inflammatory response.Journal of virology · 2025Article
- For Better or Worse: The Impact of Necrotic Cell Death Modalities.Advances in experimental medicine and biology · 2025Review
7 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
25 authors at 2 institutions in 3 countries.
Alexander D GitlinDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA. adgitlin@stanford.edu.ORCID http://orcid.org/0000-0002-9229-0919
Klaus HegerDepartment of Physiological Chemistry, Genentech, South San Francisco, CA, USA.
Alexander F SchubertDepartment of Structural Biology, Genentech, South San Francisco, CA, USA.
Rohit RejaDepartment of Bioinformatics and Computational Biology, Genentech, South San Francisco, CA, USA.
Donghong YanDepartment of Translational Immunology, Genentech, South San Francisco, CA, USA.
Victoria C PhamDepartment of Microchemistry, Proteomics and Lipidomics, Genentech, South San Francisco, CA, USA.
Eric SutoDepartment of Translational Immunology, Genentech, South San Francisco, CA, USA.
Juan ZhangDepartment of Translational Immunology, Genentech, South San Francisco, CA, USA.
Youngsu C KwonDepartment of Translational Immunology, Genentech, South San Francisco, CA, USA.
Emily C FreundDepartment of Molecular Biology, Genentech, South San Francisco, CA, USA.
Jing KangDepartment of Translational Immunology, Genentech, South San Francisco, CA, USA.
Anna PhamDepartment of Molecular Biology, Genentech, South San Francisco, CA, USA.
Roger CaothienDepartment of Molecular Biology, Genentech, South San Francisco, CA, USA.
Natasha BacarroDepartment of Molecular Biology, Genentech, South San Francisco, CA, USA.
Trent HinkleDepartment of Microchemistry, Proteomics and Lipidomics, Genentech, South San Francisco, CA, USA.
Min XuDepartment of Translational Immunology, Genentech, South San Francisco, CA, USA.
Brent S McKenzieDepartment of Translational Immunology, Genentech, South San Francisco, CA, USA.
Benjamin HaleyDepartment of Molecular Biology, Genentech, South San Francisco, CA, USA.
Wyne P LeeDepartment of Translational Immunology, Genentech, South San Francisco, CA, USA.
Jennie R LillDepartment of Microchemistry, Proteomics and Lipidomics, Genentech, South San Francisco, CA, USA.
Merone Roose-GirmaDepartment of Molecular Biology, Genentech, South San Francisco, CA, USA.
Monika DohseDepartment of Pathology, Genentech, South San Francisco, CA, USA.
Joshua D WebsterDepartment of Pathology, Genentech, South San Francisco, CA, USA.
Kim NewtonDepartment of Physiological Chemistry, Genentech, South San Francisco, CA, USA. knewton@gene.com.ORCID http://orcid.org/0000-0002-4197-0340
Vishva M DixitDepartment of Physiological Chemistry, Genentech, South San Francisco, CA, USA. dixit@gene.com.ORCID http://orcid.org/0000-0001-6983-0326
Gene Therapy Laboratory · FRDepartment of Physiological Sciences · RU
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutations in the death receptor FAS
Indexed as
Adaptor Proteins, Vesicular TransportAnimalsCaspase 8Cells, CulturedCytokinesHumansImmunity, InnateInflammationMiceMice, Inbred C57BLNuclear ProteinsRNA-Binding ProteinsToll-Like Receptor 3Toll-Like Receptor 4Tumor Necrosis Factor-alphaAdaptor Proteins, Vesicular TransportCaspase 8CytokinesN4BP1 protein, humanNuclear ProteinsRNA-Binding ProteinsTICAM1 protein, humanTLR3 protein, humanTLR4 protein, humanToll-Like Receptor 3Toll-Like Receptor 4Tumor Necrosis Factor-alpha
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.