Evidence map›Paper›PMID 32971391›Full record

ArticleDrug and alcohol dependence2020

Impact of behavioral and medication treatment for alcohol use disorder on changes in HIV-related outcomes among patients with HIV: A longitudinal analysis.

Kathleen A McGinnis, Melissa Skanderson, E Jennifer Edelman, Adam J Gordon, P Todd Korthuis, Benjamin Oldfield, Emily C Williams, Jessica Wyse, Kendall Bryant, David A Fiellin and 2 more

Open access · greenAbstract read
In one paragraph

Article in Drug and alcohol dependence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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  7. Rural Veterans with HIV and Alcohol Use Disorder receive less video telehealth than urban Veterans.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

Kathleen A McGinnisVeterans Affairs Connecticut Healthcare System, West Haven, CT, 06516 USA.
Melissa SkandersonVeterans Affairs Connecticut Healthcare System, West Haven, CT, 06516 USA.
E Jennifer EdelmanDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT, 16510 USA; National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, 20892 USA.
Adam J GordonInformatics, Decision-Enhancement, and Analytic Sciences (IDEAS) Center, VA Salt Lake City Health Care System, Salt Lake City, UT 84132, USA; Program for Addiction Research, Clinical Care, Knowledge and Advocacy (PARCKA), Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.
P Todd KorthuisOregon Health Sciences University, Portland, OR, 97239 USA.
Benjamin OldfieldDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT, 16510 USA.
Emily C WilliamsDepartment of Health Services, University of Washington School of Public Health, Seattle, WA, 98195 USA; Health Services Research & Development (HSR&D) Center of Innovation for Veteran-Centered and Value-Driven Care, Veterans Affairs (VA) Puget Sound Health Care System, Seattle, WA, 98108 USA.
Jessica WyseOregon Health Sciences University, Portland, OR, 97239 USA; Center to Improve Veteran Involvement in Care (CIVIC), VA Portland Health Care System, Portland, OR 97239, USA.
Kendall BryantNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, 20892 USA.
David A FiellinDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT, 16510 USA; Center for Interdisciplinary Research on AIDS, Yale School of Public Health, New Haven, CT, 06516 USA.
Amy C JusticeVeterans Affairs Connecticut Healthcare System, West Haven, CT, 06516 USA; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, 16510 USA.
Kevin L KraemerCenter for Research on Health Care, Division of General Internal Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213 USA; VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA.
VA Connecticut Healthcare System · USYale University · USNational Institute on Alcohol Abuse and Alcoholism · USOregon Health & Science University · USUniversity of Washington · USVA Pittsburgh Healthcare System · USVA Portland Health Care System · USVA Salt Lake City Healthcare System · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Alcohol Associated Outcomes Among HIV+/- Aging VeteransU10AA013566 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2006 to 2010
$12.7M
Alcohol and Multisubstance Use in the Veterans Aging Cohort StudyU01AA020790 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2011 to 2020
$7.7M
Sex Disparities in Overall Response to ART Among HIV Infected IndividualsU24AA020794 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2011 to 2020
$5.5M
Comparative Effectiveness of Alcohol and Drug Treatment in HIV-Infected VeteransR01AA022886 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KRAEMER, KEVIN L · 2014 to 2018
$2.4M
Expanding access to opioid use disorder treatment with buprenorphine in rural primary care settingsIK2HX003007 · VA · PORTLAND VA MEDICAL CENTER · PI WYSE, JESSICA JASMINE · 2020 to 2024
–
HSRD VA IK2 HX003007NCATS NIH HHS UL1 TR001863NIAAA NIH HHS R01 AA022886NIAAA NIH HHS U01 AA020790NIAAA NIH HHS U10 AA013566NIAAA NIH HHS U24 AA020794
6 · The paper itself

Abstract

backgroundFor people with HIV (PWH) and alcohol use disorder (AUD) who initiated behavioral treatment (BAUD) we: 1) describe BAUD intensity and medication (MAUD); and 2) examine whether BAUD and MAUD were associated with changes in HIV-related outcomes (CD4 cell count, HIV-1 viral load [VL], VACS Index score 2.0, and antiretroviral [ARV] adherence) from before to one year after treatment initiation.

methodsWe used Veterans Aging Cohort Study (VACS) data to describe BAUD intensity and MAUD (acamprosate, disulfiram, and naltrexone, gabapentin or topiramate). Linear regression models estimated changes in outcomes and included BAUD, MAUD, age and race/ethnicity.

resultsWe identified 7830 PWH who initiated BAUD from 01/2008-09/2017. Median age was 53, 60% were African-American and 28% white. BAUD intensity groups were: 1) Single Visit - 35%; 2) Minimal - 44% recieved ∼2 visits during first month; 3) Sustained Moderate - 17% recieved ∼8 visits/month initially; and 4) Intensive - 4% started out receiving ∼14-16 visits/month. Only 9% recieved MAUD, the majority of which was gabapentin. Among those with detectable VL: all HIV-related outcomes improved more among those with more intensive BAUD. Among those with undetectable VL: adherence improved more among those with greater BAUD intensity. MAUD was associated with increased CD4 among those with detectable VL and with improved adherence among both groups.

conclusionOf those with >1 BAUD visit, only 21% received at least moderate BAUD and 9% received at least 6 months of MAUD. Increasing AUD treatment intensity may improve HIV-related outcomes, especially among those with detectable VL.

Indexed as

AdultAlcohol DeterrentsAlcoholismAnti-Retroviral AgentsCognitive Behavioral TherapyCohort StudiesFemaleHIV InfectionsHumansLongitudinal StudiesMaleMiddle AgedTreatment OutcomeVeteransViral LoadAlcohol DeterrentsAnti-Retroviral AgentsAlcohol use disorderBehavioral treatmentHIVHIV outcomesMedication treatment

Identifiers

PMID32971391
PMCPMC7757793
OpenAlexW3085551395

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.