Evidence map›Paper›PMID 32971362›Full record

ArticleRedox biology2020

Glutaredoxin deficiency promotes activation of the transforming growth factor beta pathway in airway epithelial cells, in association with fibrotic airway remodeling.

Shi B Chia, James D Nolin, Reem Aboushousha, Cuixia Erikson, Charles G Irvin, Matthew E Poynter, Jos van der Velden, Douglas J Taatjes, Albert van der Vliet, Vikas Anathy and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Ethyl ferulate attenuates allergic asthma via inhibiting macrophage M2 polarization through STAT6/IRF4 pathway.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. EEF1A1 transcription cofactor gene polymorphism is associated with muscle gene expression and residual feed intake in Nelore cattle.Mammalian genome : official journal of the International Mammalian Genome Society · 2022
    Article
  6. Emerging chemistry and biology in protein glutathionylation.Current opinion in chemical biology · 2022
    Review
  7. Review
  8. Review
  9. Fully integrating pathophysiological insights in COPD: an updated working disease model to broaden therapeutic vision.European respiratory review : an official journal of the European Respiratory Society · 2021
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Shi B ChiaDepartment of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT, 05405, USA.
James D NolinDepartment of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT, 05405, USA; Center for Genes, Environment and Health, National Jewish Health, Denver, CO, 80206, USA.
Reem AboushoushaDepartment of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT, 05405, USA.
Cuixia EriksonDepartment of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT, 05405, USA.
Charles G IrvinDepartment of Medicine, University of Vermont College of Medicine, Burlington, VT, 05405, USA.
Matthew E PoynterDepartment of Medicine, University of Vermont College of Medicine, Burlington, VT, 05405, USA.
Jos van der VeldenDepartment of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT, 05405, USA.
Douglas J TaatjesDepartment of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT, 05405, USA.
Albert van der VlietDepartment of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT, 05405, USA.
Vikas AnathyDepartment of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT, 05405, USA.
Yvonne M W Janssen-HeiningerDepartment of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT, 05405, USA. Electronic address: Yvonne.janssen@uvm.edu.
University of Vermont · USUniversity of Colorado Denver · US

Funding

S-glutathionylation chemistry in fibrotic lung remodelingR35HL135828 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI JANSSEN-HEININGER, YVONNE M. W. · 2017 to 2023
$6.5M
REGULATION OF NFKB IN LUNG EPITHELIUM BY ROS/RNSR01HL060014 · NHLBI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI JANSSEN-HEININGER, YVONNE M. W. · 1999 to 2016
$5.9M
Dual Oxidase in Airway Epithelial Repair and RemodelingR01HL085646 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI VAN DER VLIET, ALBERT · 2008 to 2020
$4.7M
Mitochondrial Redox Perturbations in Obese Allergic AsthmaR01HL136917 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI ANATHY, VIKAS, DIXON, ANNE E · 2018 to 2022
$3.6M
Endoplasmic Reticulum Stress Signaling in Allergen-induced Airway RemodelingR01HL122383 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI ANATHY, VIKAS · 2015 to 2023
$3.5M
S-glutathionylation chemistry, glycolysis and obese allergic asthmaR01HL137268 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI DIXON, ANNE E, VAN DER VLIET, ALBERT · 2017 to 2020
$2.1M
DUOX1 and Mitochondria in Obese AsthmaR01HL138708 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI VAN DER VLIET, ALBERT · 2017 to 2020
$2.1M
Ketone Body Supplementation in Obese AsthmaR01HL142081 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI POYNTER, MATTHEW E · 2018 to 2021
$1.8M
GSTP1-induced S-glutathionylation in lung cancerR01CA219156 · NCI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI VAN DER VELDEN, ADRIANUS (JOS)L.J. · 2017 to 2021
$1.8M
Unfolded protein response in Influenza virus infection and inflammationR01HL141364 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI ANATHY, VIKAS · 2019 to 2022
$1.6M
Nikon A1R-ER Confocal Microscope for the Microscopy Imaging CenterS10OD025030 · OD · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI TAATJES, DOUGLAS J. · 2018 to 2018
$557k
DUOX1 Silencing in Age-Related COPDR21AG055325 · NIA · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI VAN DER VLIET, ALBERT · 2017 to 2018
$429k
NCI NIH HHS R01 CA219156NHLBI NIH HHS R01 HL060014NHLBI NIH HHS R01 HL085646NHLBI NIH HHS R01 HL122383NHLBI NIH HHS R01 HL136917NHLBI NIH HHS R01 HL137268NHLBI NIH HHS R01 HL138708NHLBI NIH HHS R01 HL141364NHLBI NIH HHS R01 HL142081NHLBI NIH HHS R35 HL135828NIA NIH HHS R21 AG055325NIH HHS S10 OD025030
6 · The paper itself

Abstract

S-glutathionylation of reactive protein cysteines is a post-translational event that plays a critical role in transducing signals from oxidants into biological responses. S-glutathionylation can be reversed by the deglutathionylating enzyme glutaredoxin (GLRX). We have previously demonstrated that ablation of Glrx sensitizes mice to the development of parenchymal lung fibrosis(1). It remains unclear whether GLRX also controls airway fibrosis, a clinical feature relevant to asthma and chronic obstructive pulmonary disease, and whether GLRX controls the biology of airway epithelial cells, which have been implicated in the pathophysiology of these diseases. In the present study we utilized a house dust mite (HDM) model of allergic airway disease in wild type (WT) and Glrx

Indexed as

Airway RemodelingEpithelial CellsGlutaredoxinsTransforming Growth Factor betaAnimalsDisease Models, AnimalFibrosisLungMiceMice, Inbred C57BLMice, KnockoutGlrx protein, mouseGlutaredoxinsTransforming Growth Factor betaAsthmaBasal cellsCOPDFibrosisS-glutathionylation

Identifiers

PMID32971362
PMCPMC7509797
OpenAlexW3086660050

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.