Evidence map›Paper›PMID 32971157›Full record

ArticleDiabetes research and clinical practice2020

Clinical features of patients with type 2 diabetes with and without Covid-19: A case control study (CoViDiab I).

Ernesto Maddaloni, Luca D'Onofrio, Francesco Alessandri, Carmen Mignogna, Gaetano Leto, Lucia Coraggio, Sara Sterpetti, Giuseppe Pascarella, Ivano Mezzaroma, Miriam Lichtner and 7 more

Open access · bronzeAbstract read
In one paragraph

Article in Diabetes research and clinical practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Statin and outcomes of coronavirus disease 2019 (COVID-19): A systematic review, meta-analysis, and meta-regression.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2021 · on this map
    Pooled it
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  8. COVID-19 and diabetes: Association intensify risk factors for morbidity and mortality.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
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  15. Emergencies in obese patients: a narrative review.Journal of anesthesia, analgesia and critical care · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

Ernesto MaddaloniUmberto I "Policlinico" General Hospital, Sapienza University of Rome, Italy.
Luca D'OnofrioUmberto I "Policlinico" General Hospital, Sapienza University of Rome, Italy.
Francesco AlessandriUmberto I "Policlinico" General Hospital, Sapienza University of Rome, Italy.
Carmen MignognaUmberto I "Policlinico" General Hospital, Sapienza University of Rome, Italy.
Gaetano LetoSanta Maria Goretti Hospital, Polo Pontino Sapienza University, Latina, Italy.
Lucia CoraggioUmberto I "Policlinico" General Hospital, Sapienza University of Rome, Italy.
Sara SterpettiUmberto I "Policlinico" General Hospital, Sapienza University of Rome, Italy.
Giuseppe PascarellaCampus Bio-Medico University of Rome, Italy.
Ivano MezzaromaUmberto I "Policlinico" General Hospital, Sapienza University of Rome, Italy.
Miriam LichtnerSanta Maria Goretti Hospital, Polo Pontino Sapienza University, Latina, Italy.
Paolo PozzilliCampus Bio-Medico University of Rome, Italy.
Felice Eugenio AgròCampus Bio-Medico University of Rome, Italy.
Monica RoccoSant'Andrea Hospital, Sapienza University of Rome, Italy.
Francesco PuglieseUmberto I "Policlinico" General Hospital, Sapienza University of Rome, Italy.
Claudio Maria MastroianniUmberto I "Policlinico" General Hospital, Sapienza University of Rome, Italy.
Raffaella BuzzettiUmberto I "Policlinico" General Hospital, Sapienza University of Rome, Italy. Electronic address: Raffaella.buzzetti@uniroma1.it.
CoViDiab Study group
Sapienza University of Rome · ITPoliclinico Umberto I · ITUniversità Campus Bio-Medico · ITOspedale Santa Maria Goretti · ITAzienda Ospedaliera Sant'Andrea · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo evaluate whether subjects with diabetes hospitalized for Coronavirus disease-19 (Covid-19) represent a subgroup of patients with high-risk clinical features compared to patients with diabetes without Covid-19.

methodsIn this case-control study 79 patients with type 2 diabetes out of 354 adults hospitalized for Covid-19 and 158 controls with type 2 diabetes but without Covid-19, matched for age and gender, were enrolled. Medical history and concomitant therapies were retrieved from medical charts and compared between cases and controls, controlling for confounders.

resultsFully-adjusted multivariate logistic regression model showed that previous CVD history did not differ between patients with and without Covid-19 (odds ratio 1.40, 95% confidence interval [CI]: 0.59-3.32, p = 0.45). A higher prevalence of chronic obstructive pulmonary disease (COPD) (OR 3.72, 95%CI: 1.42-9.72, p = 0.007) and of chronic kidney disease (CKD) (OR 3.08, 95%CI: 1.18-8.06, p = 0.022) and a lower prevalence of ever smokers (OR 0.30, 95%CI: 0.13-0.67, p = 0.003), of users of lipid lowering agents (OR 0.26, 95%CI: 0.12-0.54, p < 0.001), and of anti-hypertensive drugs (OR 0.39, 95%CI: 0.16-0.93, p = 0.033) were found among cases.

conclusionsCVD prevalence does not differ between people with diabetes with and without Covid-19 requiring hospitalization. An increased prevalence of COPD and of CKD in Covid-19 patients with type 2 diabetes is suggested. These findings aid to clarify the relationship between underlying conditions and SARS-CoV-2 infection in the high-risk group of patients with diabetes.

Indexed as

AgedAged, 80 and overCase-Control StudiesCOVID-19Diabetes Mellitus, Type 2FemaleHospitalizationHumansIncidenceItalyMalePulmonary Disease, Chronic ObstructiveRenal Insufficiency, ChronicSARS-CoV-2Covid-19DiabetesSARS-CoV-2

Identifiers

PMID32971157
PMCPMC7505069
OpenAlexW3087233574

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.