Evidence map›Paper›PMID 32971142›Full record

ArticleThe Journal of pediatrics2021

Prevention of Perinatal HIV Transmission in an Area of High HIV Prevalence in the United States.

Wei Li A Koay, Jiaqi Zhang, Krishna V Manepalli, Caleb J Griffith, Amanda D Castel, Rachel K Scott, Kathleen T Ferrer, Natella Y Rakhmanina

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Wei Li A KoayDivision of Infectious Diseases, Children's National Hospital, Washington, DC; Department of Pediatrics, School of Medicine and Health Sciences, The George Washington University, Washington, DC. Electronic address: wkoay@childrensnational.org.
Jiaqi ZhangColumbian College of Arts and Sciences, The George Washington University, Washington, DC; R&D Biostatistics, Abbott US, Abbott Park, IL.
Krishna V ManepalliDivision of Infectious Diseases, Children's National Hospital, Washington, DC.
Caleb J GriffithDivision of Infectious Diseases, Children's National Hospital, Washington, DC.
Amanda D CastelDepartment of Pediatrics, School of Medicine and Health Sciences, The George Washington University, Washington, DC; Department of Epidemiology, Milken Institute School of Public Health, The George Washington University, Washington, DC.
Rachel K ScottMedStar Health Research Institute & Washington Hospital Center, Washington, DC; School of Medicine, Georgetown University, Washington, DC.
Kathleen T FerrerDivision of Infectious Diseases, Children's National Hospital, Washington, DC; Department of Pediatrics, School of Medicine and Health Sciences, The George Washington University, Washington, DC.
Natella Y RakhmaninaDivision of Infectious Diseases, Children's National Hospital, Washington, DC; Department of Pediatrics, School of Medicine and Health Sciences, The George Washington University, Washington, DC; Elizabeth Glaser Pediatrics AIDS Foundation, Washington, DC.
Children's National · USGeorge Washington University · USAbbott Fund · USMedStar Washington Hospital Center · US

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
SWG 2: Cure Research Scientific Working GroupP30AI117970 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI Italo Mocchetti · 2015 to 2026
$29.6M
NCATS NIH HHS UL1 TR001409NIAID NIH HHS P30 AI094189NIAID NIH HHS P30 AI117970
6 · The paper itself

Abstract

objectiveTo evaluate the uptake of perinatal HIV preventive interventions by the risk of perinatal HIV transmission in mother-infant pairs in a high-HIV prevalence area in the US. STUDY

designThis was a retrospective cohort study of mother-infant pairs with perinatal HIV exposure during 2013-2017 managed at a subspecialty pediatric HIV program in Washington, DC. We collected demographic data, maternal HIV history, delivery mode, maternal and infant antiretroviral drug (ARV) use, and infant HIV test results. We compared the uptake of recommended preventive interventions in low-risk (ie, mothers on antiretroviral therapy [ART] with viral suppression) and high-risk (mothers without ART or viral suppression) mother-infant pairs using the Pearson chi-square, Fisher exact, and Wilcoxon rank-sum tests and logistic regression.

resultsWe analyzed 551 HIV-exposed infants (HEIs) and 542 mothers living with HIV. The majority of mothers received ARVs (95.5%), had HIV RNA ≤1000 copies/mL before delivery (81.9%), and received intrapartum zidovudine (ZDV; 65.5%). The majority of all HEIs were low risk (82.6%) and received postpartum ARVs (98.9%). Among the low-risk infants, 53.2% were delivered via cesarean delivery (CD), and 62.9% and 96.5% were administered intrapartum and postpartum ZDV, respectively. Among high-risk infants, 84.4% were delivered via CD, 78.1% received intrapartum ZDV, and 62.5% received combination ART. Nine high-risk infants acquired HIV perinatally.

conclusionIn an area of high HIV prevalence in the US, a large proportion of low-risk HEIs received intrapartum ZDV and were delivered via CD. We also observed missed opportunities for the prevention of perinatal HIV transmission.

Indexed as

Postpartum PeriodAdultDNA, ViralFemaleHIVHIV InfectionsHumansInfant, NewbornInfectious Disease Transmission, VerticalMalePregnancyPregnancy Complications, InfectiousPrevalencePrognosisRetrospective StudiesUnited StatesDNA, Viralantiretroviral treatmentcesarean deliveryinfantsmotherspregnancy

Identifiers

PMID32971142
PMCPMC7752838
OpenAlexW3089182354

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.