Evidence map›Paper›PMID 32971133›Full record

ReviewJournal of neuroscience methods2020

TMS-induced silent periods: A review of methods and call for consistency.

K E Hupfeld, C W Swanson, B W Fling, R D Seidler

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of neuroscience methods, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07323199 (High-Intensity Interval Training), which is not on this map. Cited by 65 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07323199 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

High-Intensity Interval Training (HIIT) and Transcranial Direct Current Stimulation (tDCS) in Women With Fibromyalgia - Effects on Clinical and Neuro-physiological Variables: Randomized Clinical Trial Protocol

TypeinterventionalSponsorUniversidad Nacional Andres BelloRan2026 to 2027Enrolled40ConditionsFibromyalgia (FM)ArmsEXERCISE TRAINING WITH OR WITHOUT MEDICATION, Neuromodulators
3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  9. The neurobiological markers of acute alcohol's subjective effects in humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Trial
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  11. Premotor cortices differentially influence contralateral motor cortex.Cerebral cortex (New York, N.Y. : 1991) · 2026
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

K E HupfeldDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA.
C W SwansonDepartment of Health & Exercise Science, Colorado State University, Fort Collins, CO, USA.
B W FlingDepartment of Health & Exercise Science, Colorado State University, Fort Collins, CO, USA; Molecular, Cellular, and Integrative Neuroscience Program, Colorado State University, Fort Collins, CO, USA.
R D SeidlerDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA; Department of Neurology, University of Florida, Gainesville, FL, USA. Electronic address: rachaelseidler@ufl.edu.

Funding

Interdisciplinary Training in Movement Disorders and NeurorestorationT32NS082168 · NINDS · UNIVERSITY OF FLORIDA · PI Melissa Jo Armstrong, David E Vaillancourt · 2015 to 2026
$2.8M
Cortical Inhibition and Mobility in Older AdultsF99AG068440 · NIA · UNIVERSITY OF FLORIDA · PI HUPFELD, KATHLEEN ELIZABETH · 2020 to 2021
$84k
NIA NIH HHS F99 AG068440NINDS NIH HHS T32 NS082168
6 · The paper itself

Abstract

Transcranial magnetic stimulation (TMS)-induced silent periods provide an in vivo measure of human motor cortical inhibitory function. Cortical silent periods (cSP, also sometimes referred to as contralateral silent periods) and ipsilateral silent periods (iSP) may change with advancing age and disease and can provide insight into cortical control of the motor system. The majority of past silent period work has implemented largely varying methodology, sometimes including subjective analyses and incomplete methods descriptions. This limits reproducibility of silent period work and hampers comparisons of silent period measures across studies. Here, we discuss methodological differences in past silent period work, highlighting how these choices affect silent period outcome measures. We also outline challenges and possible solutions for measuring silent periods in the unique case of the lower limbs. Finally, we provide comprehensive recommendations for collection, analysis, and reporting of future silent period studies.

Indexed as

Motor CortexTranscranial Magnetic StimulationElectromyographyEvoked Potentials, MotorHumansReproducibility of ResultsCortical silent periodIpsilateral silent periodNoninvasive brain stimulationTranscranial magnetic stimulation

Identifiers

PMID32971133
PMCPMC8276277

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.