Evidence map›Paper›PMID 32971096›Full record

ArticleNeuropsychologia2020

Can sex influence the neurocognition of language? Evidence from Parkinson's disease.

Jana Reifegerste, Ivy V Estabrooke, Lauren E Russell, João Veríssimo, Karim Johari, Barbara Wilmarth, Fernando L Pagan, Charbel Moussa, Michael T Ullman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychologia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Jana ReifegersteDepartment of Psychology, Westfälische Wilhelms-Universität Münster, Münster, Germany; Brain and Language Laboratory, Department of Neuroscience, Georgetown University, Washington, DC, USA; Potsdam Research Institute for Multilingualism, University of Potsdam, Potsdam, Germany. Electronic address: jana.reifegerste@gmail.com.
Ivy V EstabrookeBrain and Language Laboratory, Department of Neuroscience, Georgetown University, Washington, DC, USA; Center for Science and Technology Policy, Salt Lake City, UT, USA.
Lauren E RussellBrain and Language Laboratory, Department of Neuroscience, Georgetown University, Washington, DC, USA.
João VeríssimoDepartment of Linguistics, University of Potsdam, Potsdam, Germany.
Karim JohariDepartment of Psychology, University of South Carolina, Columbia, SC, USA.
Barbara WilmarthTranslational Neurotherapeutics Program, Laboratory for Dementia and Parkinsonism, Department of Neurology, Georgetown University Medical Center, Washington, DC, USA; Movement Disorders Clinic, Department of Neurology, MedStar Georgetown University Hospital, Washington, DC, USA.
Fernando L PaganTranslational Neurotherapeutics Program, Laboratory for Dementia and Parkinsonism, Department of Neurology, Georgetown University Medical Center, Washington, DC, USA; Movement Disorders Clinic, Department of Neurology, MedStar Georgetown University Hospital, Washington, DC, USA.
Charbel MoussaTranslational Neurotherapeutics Program, Laboratory for Dementia and Parkinsonism, Department of Neurology, Georgetown University Medical Center, Washington, DC, USA.
Michael T UllmanBrain and Language Laboratory, Department of Neuroscience, Georgetown University, Washington, DC, USA. Electronic address: michael@georgetown.edu.
Georgetown University · USGeorgetown University Medical Center · USUniversity of Potsdam · DEUniversity of South Carolina · US

Funding

The neurocognition of procedural and declarative memory in dyslexia and S-RCDR21HD087088 · NICHD · VANDERBILT UNIVERSITY · PI CUTTING, LAURIE E · 2016 to 2017
$434k
NICHD NIH HHS R21 HD087088
6 · The paper itself

Abstract

Parkinson's disease (PD), which involves basal ganglia degeneration, affects language as well as motor function. However, which aspects of language are impaired in PD and under what circumstances remains unclear. We examined whether lexical and grammatical aspects of language are differentially affected in PD, and whether this dissociation is moderated by sex as well as the degree of basal ganglia degeneration. Our predictions were based on the declarative/procedural model of language. The model posits that grammatical composition, including in regular inflection, depends importantly on left basal ganglia procedural memory circuits, whereas irregular and other lexicalized forms are memorized in declarative memory. Since females tend to show declarative memory advantages as compared to males, the model further posits that females should tend to rely on this system for regulars, which can be stored as lexicalized chunks. We tested non-demented male and female PD patients and healthy control participants on the intensively studied paradigm of English regular and irregular past-tense production. Mixed-effects regression revealed PD deficits only at regular inflection, only in male patients. The degree of left basal ganglia degeneration, as reflected by right-side hypokinesia, predicted only regular inflection, and only in male patients. Left-side hypokinesia did not show this pattern. Past-tense frequency effects suggested that the female patients retrieved regular as well as irregular past-tense forms from declarative memory, whereas the males retrieved only irregulars. Sensitivity analyses showed that the pattern of findings was robust. The results, which are consistent with the declarative/procedural model, suggest a grammatical deficit in PD due to left basal ganglia degeneration, with a relative sparing of lexical retrieval. Female patients appear to compensate for this deficit by relying on chunks stored in declarative memory. More generally, the study elucidates the neurocognition of inflectional morphology and provides evidence that sex can influence how language is computed in the mind and brain.

Indexed as

LanguageParkinson DiseaseFemaleHumansHypokinesiaLanguage TestsMaleMemoryBasal gangliaCompensationHypokinesiaParkinson's diseaseRegular and irregular inflectional morphologySex differences

Identifiers

PMID32971096
PMCPMC8613481
OpenAlexW3088066733

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.