ArticleMedical physics2020
Independent reaction times method in Geant4-DNA: Implementation and performance.
Article in Medical physics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 54 citations in OpenAlex.
- Investigation of relative biological effectiveness for protons, carbon and oxygen ion beams by DNA damage calculations in a fractal fibroblast cell geometry.Radiological physics and technology · 2026Article
- Quantifying DNA strand breaks from targeted alpha emittersEJNMMI physics · 2025Article
- The role of coating layers in gold nanorods' radioenhancement: a Monte Carlo analysis.Nanoscale advances · 2025Article
- TOPAS-nBio-Reg: a regression testing system for track structure simulations in TOPAS-nBio.Physics in medicine and biology · 2025Article
- Recent updates of the MPEXS2.1-DNA Monte Carlo code for simulations of water radiolysis under ion irradiation.Scientific reports · 2025Article
- Investigating radical yield variations in FLASH and conventional proton irradiation via microscopic Monte Carlo simulations.Physics in medicine and biology · 2025Article
- Investigation of hydrogen peroxide yields and oxygen consumption in high dose rate irradiation: a TOPAS-nBio Monte Carlo study.Physics in medicine and biology · 2024Article
- Investigating ultra-high dose rate water radiolysis using the Geant4-DNA toolkit and a Geant4 model of the Oriatron eRT6 electron linac.Scientific reports · 2024Article
- A mechanistic simulation of induced DNA damage in a bacterial cell by X- and gamma rays: a parameter study.Physical and engineering sciences in medicine · 2024Article
- Review of chemical models and applications in Geant4-DNA: Report from the ESA BioRad III Project.Medical physics · 2024Review
- Radium deposition in human brain tissue: A Geant4-DNA Monte Carlo toolkit study.Zeitschrift fur medizinische Physik · 2024Article
- GEANT4-DNA simulation of temperature-dependent and pH-dependent yields of chemical radiolytic species.Physics in medicine and biology · 2023Article
- An integrated Monte Carlo track-structure simulation framework for modeling inter and intra-track effects on homogenous chemistry.Physics in medicine and biology · 2023Article
- Application of Geant4-DNA for simulating water radiolysis induced by Auger electron-emitting radionuclides.Journal of radiation research · 2023Article
- Simulation of DNA damage using Geant4-DNA: an overview of the "molecularDNA" example application.Precision radiation oncology · 2023Article
- Modeling of DNA Damage Repair and Cell Response in Relation to p53 System Exposed to Ionizing Radiation.International journal of molecular sciences · 2022Article
- Mechanistic modelling of oxygen enhancement ratio of radiation via Monte Carlo simulation-based DNA damage calculation.Physics in medicine and biology · 2022Article
- TOPAS-nBio simulation of temperature-dependent indirect DNA strand break yields.Physics in medicine and biology · 2022Article
- Review of the Geant4-DNA Simulation Toolkit for Radiobiological Applications at the Cellular and DNA Level.Cancers · 2021Review
- DNA damage modeled with Geant4-DNA: effects of plasmid DNA conformation and experimental conditions.Physics in medicine and biology · 2021Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 6 countries.
Funding
Abstract
purposeThe simulation of individual particle tracks and the chemical stage following water radiolysis in biological tissue is an effective means of improving our knowledge of the physico-chemical contribution to the biological effect of ionizing radiation. However, the step-by-step simulation of the reaction kinetics of radiolytic species is the most time-consuming task in Monte Carlo track-structure simulations, with long simulation times that are an impediment to research. In this work, we present the implementation of the independent reaction times (IRT) method in Geant4-DNA Monte Carlo toolkit to improve the computational efficiency of calculating G-values, defined as the number of chemical species created or lost per 100 eV of deposited energy.
methodsThe computational efficiency of IRT, as implemented, is compared to that from available Geant4-DNA step-by-step simulations for electrons, protons and alpha particles covering a wide range of linear energy transfer (LET). The accuracy of both methods is verified using published measured data from fast electron irradiations for
resultsThe IRT improved the computational efficiency by three orders of magnitude relative to the step-by-step method while differences in G-values by 3.9% at 1 μs were found. At 7 ps,
conclusionThe comprehensive validation of the Geant4-DNA capabilities to accurately simulate the chemistry following water radiolysis is an ongoing work. The implementation presented in this work is a necessary step to facilitate performing such a task.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.