ArticlePharmaceutical biology2020
Polysaccharide of
Article in Pharmaceutical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Mechanistic study on ligustilide modulation of the TLR4/NF-κB pathway in ameliorating Scopolamine-Induced cognitive impairment.Metabolic brain disease · 2025Article
- Advancements in the Cultivation, Active Components, and Pharmacological Activities ofMolecules (Basel, Switzerland) · 2024Review
- Based on Bioinformatics to Explore the Mechanism of "Tangzhiqing" Decoction Alleviating Type 2 Diabetes-associated Cognitive Dysfunction in Mice by Regulating Hippocampal Neuron Apoptosis and Autophagy.Combinatorial chemistry & high throughput screening · 2024Article
- Analysis of the utilization value of different tissues of Taxus×Media based on metabolomics and antioxidant activity.BMC plant biology · 2023Article
- The Potential of Edible and Medicinal Resource Polysaccharides for Prevention and Treatment of Neurodegenerative Diseases.Biomolecules · 2023Review
- Unveiling the neuroprotective potential of dietary polysaccharides: a systematic review.Frontiers in nutrition · 2023Review
- Advances in health-promoting effects of natural polysaccharides: Regulation on Nrf2 antioxidant pathway.Frontiers in nutrition · 2023Review
- Protective Effects of Polysaccharides in Neurodegenerative Diseases.Frontiers in aging neuroscience · 2022Review
- Natural Polysaccharides as Preventive and Therapeutic Horizon for Neurodegenerative Diseases.Pharmaceutics · 2021Review
- Baicalin Rescues Cognitive Dysfunction, Mitigates Neurodegeneration, and Exerts Anti-Epileptic Effects Through Activating TLR4/MYD88/Caspase-3 Pathway in Rats.Drug design, development and therapy · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextPolysaccharide of
objectiveTo investigate the effect of PTM on AD. MATERIALS AND
methodsC57BL/6J mice were randomly divided into three groups: control, d-galactose (d-gal), and d-gal + PTM. AD-like symptom was induced by d-gal for 6 weeks, followed with PTM (0.4 g/kg/d) for 14 days. PTM was added to BV2 cells stimulated with d-gal (1, 10, 20, 50, 100 and 500 μg/mL). Cell viability was evaluated by MTT assay. The expression of NRF2, SOD, cleaved caspase-3, Bax and Bcl-2 were detected with Western blot analysis. Cognitive function was evaluated by Morris water maze test.
resultsDecreased cleaved caspase-3 (1.30 ± 0.09) and Bax/Bcl2 ratio (1.32 ± 0.11) were observed in BV2 cells induced by d-gal + PTM (50 μg/mL). Increased MDA and ROS and decreased SOD were observed in d-gal group. However, decreased MDA (175 ± 9 ng/mL) and ROS level (188 ± 38 ng/mL) were observed after treated with PTM group (
conclusionsThis is the first report that PTM inhibited oxidative stress and apoptosis in AD. The result will further accelerate the applications of
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