Evidence map›Paper›PMID 32970404›Full record

ArticleACS infectious diseases2020

Resistance to Some But Not Other Dimeric Lindenane Sesquiterpenoid Esters Is Mediated by Mutations in a

Joshua H Butler, Rodrigo P Baptista, Ana L Valenciano, Bin Zhou, Jessica C Kissinger, Patrick K Tumwebaze, Philip J Rosenthal, Roland A Cooper, Jian-Min Yue, Maria B Cassera

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Identification of an Orally Efficacious Imidazo[4,5-Journal of medicinal chemistry · 2026
    Article
  2. Prodrug activation in malaria parasites mediated by an imported erythrocyte esterase, acylpeptide hydrolase (APEH).Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Transcriptome-Based Identification of a FunctionalPathogens (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Joshua H ButlerDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, United States.
Rodrigo P BaptistaCenter for Tropical and Emerging Global Diseases (CTEGD), University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0002-1806-8260
Ana L ValencianoDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0002-5516-7452
Bin ZhouState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
Jessica C KissingerCenter for Tropical and Emerging Global Diseases (CTEGD), University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0002-6413-1101
Patrick K TumwebazeInfectious Diseases Research Collaboration, Kampala, Uganda.
Philip J RosenthalDepartment of Medicine, University of California, San Francisco, California 94110, United States.
Roland A CooperDepartment of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California 94901, United States.
Jian-Min YueState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.ORCID 0000-0002-4053-4870
Maria B CasseraDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0001-6341-3169
University of Georgia · USChinese Academy of Sciences · CNDominican University of California · USInfectious Diseases Research Collaboration · UGUniversity of California, San Francisco · US

Funding

Mechanisms of varied sensitivity of P. falciparum field isolates to the antimalarial drug pipelineR01AI139179 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Philip Jon Rosenthal · 2018 to 2026
$6.3M
Training in Tropical and Emerging Global Diseases - SupplementT32AI060546 · NIAID · UNIVERSITY OF GEORGIA (UGA) · PI Silvia N Moreno, Vasant Muralidharan · 2004 to 2026
$5.1M
Discovery and Mechanism of Antimalarial Natural ProductsR01AT008088 · NCCIH · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI CASSERA, MARIA BELEN, CLEMENT, JASON ANDERSON · 2014 to 2018
$2.0M
NCCIH NIH HHS R01 AT008088NIAID NIH HHS R01 AI139179NIAID NIH HHS T32 AI060546
6 · The paper itself

Abstract

Unique lindenane sesquiterpenoid dimers from

Indexed as

AntimalarialsSesquiterpenesEsterasesEstersMutationPlasmodium falciparumAntimalarialsEsterasesEstersSesquiterpeneslindenane sesquiterpenoid dimersMalaria BoxPathogen BoxPfPAREPlasmodiumstructure-resistance relationship study

Identifiers

PMID32970404
PMCPMC11075783
OpenAlexW3088605868

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.