ArticleAlcoholism, clinical and experimental research2020
Prospective Study Examining the Effects of Extreme Drinking on Brain Structure in Emerging Adults.
Article in Alcoholism, clinical and experimental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- High-intensity and blackout drinking impact on next-day cognitive functioning among college-attending young adults.Alcohol, clinical & experimental research · 2026Article
- Acute Next-Day Effects of Alcohol Use on Daily Cognitive Functioning Among Young Adults: Protocol for a 21-Day Diary Study.JMIR research protocols · 2025Article
- Dysregulation of neurotrophin expression in prefrontal cortex and nucleus basalis magnocellularis during and after adolescent intermittent ethanol exposure.Alcohol (Fayetteville, N.Y.) · 2024Article
- A latent profile analysis of blackout drinking behavior among young adults.Drug and alcohol dependence · 2023Article
- Associations between blackout drinking and self-reported everyday cognition among young adults.Addictive behaviors · 2023Article
- Alcohol's effects on the mouse brain are modulated by age and sex.Addiction biology · 2022Article
- Alcohol use in emerging adults associated with lower rich-club connectivity and greater connectome network disorganization.Drug and alcohol dependence · 2022Article
- Prospective Study Examining the Effects of Extreme Drinking on Brain Structure in Emerging Adults.Alcoholism, clinical and experimental research · 2020Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEmerging adulthood is a critical neurodevelopment period in which extreme drinking has a potentially pronounced neurotoxic effect. Therefore, extreme drinking, even a single episode, could be particularly harmful to the developing brain's structure. Relatedly, heavy alcohol use in emerging adults has been associated with structural brain damage, especially in the corpus callosum. However, it is unclear whether and how much a single extreme drinking episode would affect brain morphometry.
methodsFor the first time in the literature, the current study prospectively examined the impact of an extreme drinking episode (i.e., twenty-first birthday celebration) on the brain morphometry of emerging adults immediately following their birthday celebration (n = 50) and approximately 5 weeks post-birthday celebration (n = 29).
resultsWe found evidence that a single extreme drinking episode was associated with structural changes immediately post-birthday celebration. Specifically, higher twenty-first birthday estimated blood-alcohol concentration was associated with decreased volume of the posterior and central corpus callosum immediately post-birthday celebration. This extreme drinking episode was not associated with further structural changes, or recovery, 5 weeks post-twenty-first birthday celebration.
conclusionsOverall, results suggest that a single episode of heavy drinking in emerging adulthood may be associated with immediate structural changes of the corpus callosum. Thus, emerging adulthood, which is characterized by high rates of extreme drinking, could be a critical period for targeted prevention and intervention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.