Evidence map›Paper›PMID 32970316›Full record

Observational studyAdvances in therapy2020

Combined Intravitreal Dexamethasone Implant and Cataract Surgery in Patients with Diabetic Retinopathy: Effect on Retinal Morphology and Function.

Angelo Maria Minnella, Martina Maceroni, Stefano Maria Picardi, Giorgio Placidi, Elisa De Siena, Stanislao Rizzo, Benedetto Falsini

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Advances in therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Risk of diabetic retinopathy progression after YAG laser capsulotomy.Journal of cataract and refractive surgery · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Angelo Maria MinnellaUniversità Cattolica del Sacro Cuore, Rome, Italy.
Martina MaceroniUniversità Cattolica del Sacro Cuore, Rome, Italy. maceronimartina@gmail.com.ORCID 0000-0002-3754-7486
Stefano Maria PicardiUniversità Cattolica del Sacro Cuore, Rome, Italy.
Giorgio PlacidiUniversità Cattolica del Sacro Cuore, Rome, Italy.
Elisa De SienaUniversità Cattolica del Sacro Cuore, Rome, Italy.
Stanislao RizzoUniversità Cattolica del Sacro Cuore, Rome, Italy.
Benedetto FalsiniUniversità Cattolica del Sacro Cuore, Rome, Italy.
Università Cattolica del Sacro Cuore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCataract surgery can be associated with vision-threatening complications in patients with diabetes. This study aimed to assess the functional and anatomic outcomes of the intravitreal dexamethasone (DEX) implant, administered at the time as cataract surgery, in patients with diabetic retinopathy and diabetic macular edema (DME).

methodsThis was a retrospective, observational, and single-center study. The primary endpoint was the mean change in central macular thickness (CMT) from baseline to month 1. Secondary endpoints included mean change in best corrected visual acuity (BCVA) from baseline to month 1 and 3, mean change in CMT from baseline to month 3, the photopic negative response (PhNR) and the b wave of flash full-field electroretinogram from baseline to month 1, and the incidence of adverse events.

resultsTwenty-four eyes of 21 patients were included in the study. The mean (range) age of patients was 69 (63-87) years and 13 (61.9%) were men. Mean (standard deviation) CMT significantly decreased from 447 (134) µm at baseline to 341 (134) µm at month 1 (mean difference - 106 ± 134 µm, 95% CI - 183.9 to - 28.1 µm; p = 0.0087). BCVA significantly improved from 46 (20) ETDRS letters at baseline to 59 (22) ETDRS letters at month 1 (mean difference 13 ± 21 letters, 95% CI 0.8-25.2 letters; p = 0.0375). Regarding electrophysiology, there was a statistically significant reduction in mean PhNR from 5.24 (1.67) µV at baseline to 3.73 (1.19) µV at month 1 (mean difference - 1.51 ± 0.42 µV, 95% CI - 2.4 to - 0.7 µV, p = 0.0008); whereas b wave amplitude did not change (12.69 ± 6.89 µV at baseline versus 12.29 ± 6.30 µV at month 1; p = 0.8347). Four (16.7%) eyes developed ocular hypertension over the course of follow-up, which was successfully controlled with topical hypotensive medication.

conclusionPerioperative DEX implant significantly improved both anatomic and functional outcomes in patients with DME who underwent cataract surgery.

Indexed as

CataractDiabetes MellitusDiabetic RetinopathyMacular EdemaAgedAged, 80 and overDexamethasoneDrug ImplantsGlucocorticoidsHumansIntravitreal InjectionsMaleRetrospective StudiesTomography, Optical CoherenceVisual AcuityDexamethasoneDrug ImplantsGlucocorticoidsCataractDiabetesDiabetic macular edemaDiabetic retinopathyElectrophysiologyMacular thicknessPersonalized medicineVisual acuity

Identifiers

PMID32970316
PMCPMC7547947
OpenAlexW3088138563

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.