ArticleInternational urology and nephrology2021
Longer sleep duration may negatively affect renal function.
Article in International urology and nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 15 citations in OpenAlex.
- U-shaped association between estimated glomerular filtration rate and mortality in HSV-positive adults: A retrospective cohort study.Medicine · 2026Article
- Sleep duration may not have any effect on the risk of stroke: insights from Mendelian randomization and prospective cohort studies.Archives of medical science : AMS · 2026Article
- The impact of sleep duration on the incidence of new-onset chronic kidney disease in community-dwelling adults: a nationwide cohort study.Annals of medicine · 2025Article
- Long nighttime sleep duration and risk of renal tubular damage: evidence from rural China and a Mendelian randomization analysis.Renal failure · 2025Observational
- Circulating metabolites and bladder cancer: a Mendelian randomization and multi-omics study.Discover oncology · 2025Article
- Phenome-wide associations of sleep characteristics in the Human Phenotype Project.Nature medicine · 2025Article
- Sleep disturbances and heart failure: observational study and Mendelian randomization study.Archives of medical science : AMS · 2025Article
- A 360° perspective on cardiovascular prevention: the International Lipid Expert Panel SiMple tIps for the heaLthy hEart (ILEP-SMILE).Archives of medical science : AMS · 2025Article
- Insomnia and sleep duration for kidney function: Mendelian randomization study.Renal failure · 2024Article
- Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults.Frontiers of medicine · 2024Article
- The nonlinear relationship between estimated glomerular filtration rate and cardiovascular disease in US adults: a cross-sectional study from NHANES 2007-2018.Frontiers in cardiovascular medicine · 2024Article
- Mendelian randomization analysis reveals causal factors behind diabetic nephropathy: evidence, opportunities, and challenges.Frontiers in endocrinology · 2024Review
- Selection of genetic instruments in Mendelian randomisation studies of sleep traits.Sleep medicine · 2023Review
- Leveraging genetic discoveries for sleep to determine causal relationships with common complex traits.Sleep · 2022Review
- Self-reported and objective sleep duration in patients with CKD: are they telling the same story?Jornal brasileiro de nefrologiaArticle
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Authors and funding
4 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObservational studies evaluating the link between sleep duration and kidney function reported controversial results. In the present study, Mendelian randomization analysis was applied to obtain unconfounded estimates of the casual association of genetically determined sleep duration with estimated glomerular filtration rate and the risk of chronic kidney disease.
methodsData from the largest genome-wide association studies on self-reported and accelerometer-derived sleep duration, estimated glomerular filtration rate and chronic kidney disease were analysed in total, as well as separately in diabetic and non-diabetic individuals. Inverse variance weighted (IVW) method, weighted median-based method, MR-Egger and MR-Pleiotropy RESidual Sum and Outlier (MR-PRESSO) were applied, as well as the leave-one-out method to rule out the impact of single single-nucleotide polymorphism.
resultsIndividuals with genetically longer self-reported sleep duration had a higher chronic kidney disease risk (IVW: β = 0.358, p = 0.047). Furthermore, in non-diabetics, longer self-reported sleep duration was negatively associated with estimated glomerular filtration rate (IVW: β = - 0.024, p = 0.020). Similarly, accelerometer-derived sleep duration was negatively related to estimated glomerular filtration rate in the total population (IVW: β = - 0.019, p = 0.047) and then on-diabetic individuals. No significant association was found between self-reported sleep duration and estimated glomerular filtration rate in the whole population and type-2 diabetes mellitus patients. None of the estimated associations was subjected to a significant level of heterogeneity. MR-PRESSO analysis did not show any chance of outliers for all estimates. The pleiotropy test also indicated low chance of pleiotropy. The leave-one-out method demonstrated that the links were not driven by single-nucleotide polymorphisms.
conclusionsFor the first time, the present study shed a light on the potential harmful effects of longer sleep duration (measured both objectively and subjectively) on kidney function. This finding was observed in the total population and in non-diabetic individuals, but not in those with diabetes. Further research is needed to elucidate the links between sleep duration, estimated glomerular filtration rate and the risk of chronic kidney disease.
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