ArticleBrain structure & function2020
GABA-glutamate supramammillary neurons control theta and gamma oscillations in the dentate gyrus during paradoxical (REM) sleep.
Article in Brain structure & function, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 56 citations in OpenAlex.
- Hippocampal long-range GABAergic neurons target hippocampal-projecting cells of the supramammillary area.The Journal of physiology · 2026Article
- Electroacupuncture Ameliorates Learning and Memory Deficits in Vascular Cognitive Impairment Rats Through Activation of the Supramammillary Nucleus-Dentate Gyrus Circuit.CNS neuroscience & therapeutics · 2026Article
- Article
- ALDH2-mediated GABA biosynthesis regulates hippocampal LTP and learning adaptability.Nature chemical biology · 2026Article
- Hippocampo-supramammillary coupling across sleep and wake.Scientific reports · 2026Article
- Perisomatic innervation on the semilunar granule cells and outer molecular layer granule cells of the dentate gyrus of the mouse.Frontiers in neuroanatomy · 2026Article
- Noradrenergic Slow Vasomotion: The Hidden Fluid Pump Linking Sleep, Brain Clearance, and Dementia Pathogenesis.International journal of molecular sciences · 2025Review
- Noncanonical circuits, states, and computations of the hippocampus.Science (New York, N.Y.) · 2025Review
- Activation of the supramammillary-dentate gyrus circuit enhances alertness and cognitive function in a rat model of ADHD.Translational psychiatry · 2025Article
- The absence of Neuroligin-1 shapes wake/sleep architecture, rhythmic and arrhythmic activities of the electrocorticogram in female mice.Molecular brain · 2025Article
- Neural circuits and emotional processing in rapid eye movement sleep.Frontiers in psychiatry · 2025Review
- Article
- Distinct Functional Classes of CA1 Hippocampal Interneurons Are Modulated by Cerebellar Stimulation in a Coordinated Manner.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Glutamatergic supramammillary nucleus neurons respond to threatening stressors and promote active coping.eLife · 2024Article
- Hypothalamic supramammillary neurons that project to the medial septum modulate wakefulness in mice.Communications biology · 2023Article
- Hypothalamic Supramammillary Control of Cognition and Motivation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- Upper cortical layer-driven network impairment in schizophrenia.Science advances · 2022Article
- Construction of complex memories via parallel distributed cortical-subcortical iterative integration.Trends in neurosciences · 2022Review
- Excitatory selective LTP of supramammillary glutamatergic/GABAergic cotransmission potentiates dentate granule cell firing.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Functional Neuroanatomy of the Rat Nucleus Incertus-Medial Septum Tract: Implications for the Cell-Specific Control of the Septohippocampal Pathway.Frontiers in cellular neuroscience · 2022Article
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Authors and funding
15 authors at 6 institutions in 3 countries.
Funding
Abstract
Several studies suggest that neurons from the lateral region of the SuM (SuML) innervating the dorsal dentate gyrus (DG) display a dual GABAergic and glutamatergic transmission and are specifically activated during paradoxical (REM) sleep (PS). The objective of the present study is to characterize the anatomical, neurochemical and electrophysiological properties of the SuML-DG projection neurons and to determine how they control DG oscillations and neuronal activation during PS and other vigilance states. For this purpose, we combine structural connectivity techniques using neurotropic viral vectors (rabies virus, AAV), neurochemical anatomy (immunohistochemistry, in situ hybridization) and imaging (light, electron and confocal microscopy) with in vitro (patch clamp) and in vivo (LFP, EEG) optogenetic and electrophysiological recordings performed in transgenic VGLUT2-cre male mice. At the cellular level, we show that the SuML-DG neurons co-release GABA and glutamate on dentate granule cells and increase the activity of a subset of DG granule cells. At the network level, we show that activation of the SuML-DG pathway increases theta power and frequency during PS as well as gamma power during PS and waking in the DG. At the behavioral level, we show that the activation of this pathway does not change animal behavior during PS, induces awakening during slow wave sleep and increases motor activity during waking. These results suggest that the SuML-DG pathway is capable of supporting the increase of theta and gamma power in the DG observed during PS and plays an important modulatory role of DG network activity during this state.
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