Evidence map›Paper›PMID 32970218›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2021

Multiparametric PET and MRI of myocardial damage after myocardial infarction: correlation of integrin αvβ3 expression and myocardial blood flow.

Marcus R Makowski, Christoph Rischpler, Ullrich Ebersberger, Alexandra Keithahn, Markus Kasel, Ellen Hoffmann, Tienush Rassaf, Horst Kessler, Hans-Jürgen Wester, Stephan G Nekolla and 2 more

Abstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Natural History of Myocardial αJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Trial
  3. Next-generation molecular imaging of cardiac fibrosis.The international journal of cardiovascular imaging · 2026
    Review
  4. Molecular Imaging of Collagen Turnover in Myocardial Infarction.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  5. Molecular Imaging of Collagen Turnover in Myocardial Infarction.bioRxiv : the preprint server for biology · 2026
    Article
  6. [European journal of nuclear medicine and molecular imaging · 2026
    Article
  7. Review
  8. Review
  9. Interaction of integrin αFrontiers in cell and developmental biology · 2025
    Article
  10. Positron emission tomography probes for stem cell monitoring: a review.American journal of translational research · 2024
    Review
  11. Review
  12. Article
  13. [Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  14. Targeted imaging of angiogenesis post-myocardial infarction predicts development of heart failure.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  15. Article
  16. [Diagnostics (Basel, Switzerland) · 2023
    Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Marcus R Makowski *Department of Nuclear Medicine, School of Medicine, Technical University of Munich, Munich, Germany.
Christoph Rischpler *Department of Nuclear Medicine, School of Medicine, Technical University of Munich, Munich, Germany. Christoph.Rischpler@uk-essen.de.ORCID https://orcid.org/0000-0002-5545-8487
Ullrich EbersbergerDepartment of Cardiology, Klinikum Bogenhausen, Munich, Germany.
Alexandra KeithahnDepartment of Nuclear Medicine, School of Medicine, Technical University of Munich, Munich, Germany.
Markus KaselDepartment of Cardiology, Klinikum Bogenhausen, Munich, Germany.
Ellen HoffmannDepartment of Cardiology, Klinikum Bogenhausen, Munich, Germany.
Tienush RassafDepartment of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Horst KesslerDepartment of Chemistry, Institute for Advanced Study and Center of Integrated Protein Science, Technical University of Munich, Garching, Germany.
Hans-Jürgen WesterPharmaceutical Radiochemistry, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany.
Stephan G NekollaDepartment of Nuclear Medicine, School of Medicine, Technical University of Munich, Munich, Germany.
Markus Schwaiger *Department of Nuclear Medicine, School of Medicine, Technical University of Munich, Munich, Germany.
Ambros J Beer *Department of Nuclear Medicine, School of Medicine, Technical University of Munich, Munich, Germany.

Funding

Sixth Framework Programme LSHBCT-2005-512146
6 · The paper itself

Abstract

purposeIncreased angiogenesis after myocardial infarction is considered an important favorable prognostic parameter. The αvβ3 integrin is a key mediator of cell-cell and cell-matrix interactions and an important molecular target for imaging of neovasculature and repair processes after MI. Thus, imaging of αvβ3 expression might provide a novel biomarker for assessment of myocardial angiogenesis as a prognostic marker of left ventricular remodeling after MI. Currently, there is limited data available regarding the association of myocardial blood flow and αvβ3 integrin expression after myocardial infarction in humans.

methodsTwelve patients were examined 31 ± 14 days after MI with PET/CT using [

resultsIn 5 patients, increased [

conclusion[

Indexed as

Integrin alphaVbeta3Myocardial InfarctionHumansMagnetic Resonance ImagingMyocardiumPositron-Emission TomographyPositron Emission Tomography Computed TomographyProspective StudiesIntegrin alphaVbeta3AngiogenesisIntegrin αvβ3Molecular imagingMyocardial infarctionPET/CT

Identifiers

PMID32970218
PMCPMC8041712

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.