ArticleNeurosurgery2021
Survival Trends After Surgery for Spinal Metastatic Tumors: 20-Year Cancer Center Experience.
Article in Neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The influence of immunohistochemistry-based subtypes on overall survival in breast cancer spine metastases: a systematic review and meta-analysis.BMC medicine · 2026Pooled it
- Radiation therapy, radiosurgery, chemotherapy and targeted therapies for metastatic spine tumors: WFNS Spine committee recommendations.Neurosurgical review · 2024Pooled it
- Stereotactic body radiation therapy in elderly patients with spinal metastases.Journal of neuro-oncology · 2026Article
- Finite element validation and short-term clinical outcomes of robot-assisted percutaneous microwave ablation plus cement augmentation and sacroiliac screw fixation for upper sacral (S1-S2) metastases.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Current Trends in Therapeutic Outcomes Among Patients With Metastatic Renal Cell Carcinoma of the Spine: A Systematic Review and Meta-Analysis.Global spine journal · 2026Review
- [Surgical management of spinal metastases].Orthopadie (Heidelberg, Germany) · 2026Review
- Trends and postoperative complications of spinal metastasis surgery in Thailand between 2015 and 2024: a nationwide retrospective cohort study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Carbon fiber-reinforced peek versus titanium implants for the surgical treatment of spinal metastases: Evaluation of local disease control and quality of life.Journal of bone oncology · 2026Article
- A novel inflammatory-nutritional nomogram for predicting survival after minimally invasive surgery for spinal metastases: a comparison with the Katagiri and SORG systems.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Risk Factors for Vertebral Compression Fracture Following Spine Stereotactic Body Radiation Therapy.Advances in radiation oncology · 2026Article
- Vertebral metastatic disease: A paradigm shift.Neuro-oncology advances · 2026Review
- Outcomes of patients with cervical spine metastasis treated with different surgical approaches-decision based on location.World journal of surgical oncology · 2026Article
- Evaluation of the Enhanced Recovery After Surgery (ERAS) Guidance for Patients With Spinal Metastasis.Orthopaedic surgery · 2026Review
- Predictors and Early Outcomes of Hidden Blood Loss Following Surgery for Spinal Metastases: A Retrospective Study Focusing on Tomita Type 1-5 Lesions.Journal of clinical medicine · 2026Article
- Ablative Techniques for the Management of Osseous Spine Metastases: A Narrative Review.Journal of clinical medicine · 2025Review
- Application of deformity principles in the management of spinal neoplasms: A Primer.North American Spine Society journal · 2025Article
- Advances in Metastatic Disease Spinal Oncology: Novel Technology Without Forgetting the Fundamentals of Surgical Treatment.Neurospine · 2025Article
- Survival days of patients with metastatic spinal tumors of lung cancer requiring surgery: a prospective multicenter study.Scientific reports · 2025Article
- Integration of Next Generation Sequencing Data to Inform Survival Prediction of Patients with Spine Metastasis.Cancers · 2025Article
- Health- related quality of life after surgery for spinal metastases.Journal of bone oncology · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundOver the last 2 decades, advances in systemic therapy have increased the expected overall survival for patients with cancer. It is unclear whether the same survival benefit has been conferred to patients requiring surgery for metastatic spinal disease.
objectiveTo examine trends in postoperative survival over a 20-yr period for patients surgically treated for spinal metastatic disease.
methodsData were obtained for 1515 patients who underwent surgery for metastatic epidural spinal cord compression or tumor-related mechanical instability. Postoperative overall survival was calculated for all included patients using Kaplan-Meier methodology from date of surgery until death or last follow-up for those who were censored. Trends were analyzed using Cox proportional hazards modeling.
resultsPatients with renal, breast, lung, and colon cancers experienced a statistically significant improvement in survival over time based on the year of surgery (40%-100% improvement over the study period), whereas the overall survival trend for the entire cohort did not reach statistical significance (P = .12, median survival 0.71 yr, 95% CI 0.63-0.78). Patients presenting with synchronous metastatic disease had better survival compared to those presenting with metachronous disease (median overall survival: 0.94 vs 0.63 yr, respectively; log-rank P-value = .00001).
conclusionThe postoperative survival among patients with spinal metastases has improved over the past 20 yr, particularly in patients with kidney, breast, lung, and colon tumors metastatic to the spine. The observed survival improvement emphasizes the need for long-term outcome consideration in treatment decisions for patients undergoing surgery for spinal metastatic tumors.
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