Evidence map›Paper›PMID 32969959›Full record

ArticleJournal of pediatric gastroenterology and nutrition2021

Living Related Liver Transplantation for Metabolic Liver Diseases in Children.

Vikrant Sood, James E Squires, George V Mazariegos, Jerry Vockley, Patrick J McKiernan

Open access · greenAbstract read
In one paragraph

Article in Journal of pediatric gastroenterology and nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Severity-adjusted evaluation of liver transplantation on health outcomes in urea cycle disorders.Genetics in medicine : official journal of the American College of Medical Genetics · 2024
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Vikrant SoodDepartment of Pediatric Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.
James E SquiresDivision of Gastroenterology, Hepatology and Nutrition.
George V MazariegosDivision of Pediatric Transplantation, Hillman Center for Pediatric Transplantation.
Jerry VockleyCenter for Rare Disease Therapy, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA.
Patrick J McKiernanDivision of Gastroenterology, Hepatology and Nutrition.
Children's Hospital of Pittsburgh · USInstitute of Liver and Biliary Sciences · IN

Funding

Pittsburgh Liver Research CenterP30DK120531 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Gavin E Arteel · 2019 to 2026
$10.9M
Characterization of Branched Chain Amino Acid Metabolism and Its DeficiencyR01DK109907 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VOCKLEY, GERARD · 2016 to 2024
$4.1M
NIDDK NIH HHS P30 DK120531NIDDK NIH HHS R01 DK109907
6 · The paper itself

Abstract

abstractMetabolic liver diseases (MLDs) are a heterogeneous group of inherited conditions for which liver transplantation can provide definitive treatment. The limited availability of deceased donor organs means some who could benefit from transplant do not have this option. Living related liver transplant (LrLT) using relatives as donors has emerged as one solution to this problem. This technique is established worldwide, especially in Asian countries, with shorter waiting times and patient and graft survival rates equivalent to deceased donor liver transplantation. However, living donors are underutilized for MLDs in many western countries, possibly due to the fear of limited efficacy using heterozygous donors. We have reviewed the published literature and shown that the use of heterozygous donors for liver transplantation is safe for the majority of MLDs with excellent metabolic correction. The use of LrLT should be encouraged to complement deceased donor liver transplantation (DDLT) for treatment of MLDs.

Indexed as

Liver DiseasesLiver TransplantationAsiaChildHumansLiving DonorsRetrospective StudiesSurvival RateTreatment Outcome

Identifiers

PMID32969959
PMCPMC10657650
OpenAlexW3089125546

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.