Evidence map›Paper›PMID 32969833›Full record

Trial reportJournal of medical Internet research2020

An Internet-Based Intervention Augmented With a Diet and Physical Activity Consultation to Decrease the Risk of Dementia in At-Risk Adults in a Primary Care Setting: Pragmatic Randomized Controlled Trial.

Kaarin J Anstey, Nicolas Cherbuin, Sarang Kim, Mitchell McMaster, Catherine D'Este, Nicola Lautenschlager, George Rebok, Ian McRae, Susan J Torres, Kay L Cox and 1 more

Open access · goldAbstract readRandomized Controlled TrialPragmatic Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of medical Internet research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Kaarin J AnsteySchool of Psychology, University of New South Wales, Sydney, Australia.ORCID 0000-0002-9706-9316
Nicolas CherbuinCentre for Research on Ageing, Health and Wellbeing, Australian National University, Canberra, Australia.ORCID 0000-0001-6481-0748
Sarang KimWicking Dementia Resaerch & Education Centre, University of Tasmania, Hobart, Australia.ORCID 0000-0003-4869-9255
Mitchell McMasterCentre for Research on Ageing, Health and Wellbeing, Australian National University, Canberra, Australia.ORCID 0000-0002-9110-4870
Catherine D'EsteNational Centre for Epidemiology and Public Health, Australian National University, Canberra, Australia.ORCID 0000-0001-9125-0483
Nicola LautenschlagerAcademic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Australia.ORCID 0000-0003-4850-7794
George RebokJohns Hopkins Centre on Aging and Health, Johns Hopkins University, Baltimore, MD, United States.ORCID 0000-0002-5371-8767
Ian McRaeCentre for Research on Ageing, Health and Wellbeing, Australian National University, Canberra, Australia.ORCID 0000-0001-6200-7476
Susan J TorresInstitute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Melbourne, Australia.ORCID 0000-0002-2599-1934
Kay L CoxMedical School, University of Western Australia, Perth, Australia.ORCID 0000-0003-0780-5437
Constance Dimity PondDepartment of General Practice, University of Newcastle, Newcastle, Australia.ORCID 0000-0001-6520-4213
Australian National University · AUDeakin University · AUJohns Hopkins University · USThe University of Melbourne · AUThe University of Western Australia · AUUniversity of Newcastle Australia · AUUniversity of Tasmania · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is a need to develop interventions to reduce the risk of dementia in the community by addressing lifestyle factors and chronic diseases over the adult life course.

objectiveThis study aims to evaluate a multidomain dementia risk reduction intervention, Body Brain Life in General Practice (BBL-GP), targeting at-risk adults in primary care.

methodsA pragmatic, parallel, three-arm randomized trial involving 125 adults aged 18 years or older (86/125, 68.8% female) with a BMI of ≥25 kg/m

resultsBaseline assessments were conducted on 128 participants. A total of 125 participants were randomized to 3 groups (BBL-GP=42, LMP=41, and control=42). At immediate, week 18, week 36, and week 62 follow-ups, the completion rates were 43% (18/42), 57% (24/42), 48% (20/42), and 48% (20/42), respectively, for the BBL-GP group; 71% (29/41), 68% (28/41), 68% (28/41), and 51% (21/41), respectively, for the LMP group; and 62% (26/42), 69% (29/42), 60% (25/42), and 60% (25/42), respectively, for the control group. The primary outcome of the ANU-ADRI-SF score was lower for the BBL-GP group than the control group at all follow-ups. These comparisons were all significant at the 5% level for estimates adjusted for baseline differences (immediate: difference in means -3.86, 95% CI -6.81 to -0.90, P=.01; week 18: difference in means -4.05, 95% CI -6.81 to -1.28, P<.001; week 36: difference in means -4.99, 95% CI -8.04 to -1.94, P<.001; and week 62: difference in means -4.62, 95% CI -7.62 to -1.62, P<.001).

conclusionsA web-based multidomain dementia risk reduction program augmented with allied health consultations administered within the general practice context can reduce dementia risk exposure for at least 15 months. This study was limited by a small sample size, and replication on a larger sample with longer follow-up will strengthen the results.

trial registrationAustralian clinical trials registration number (ACTRN): 12616000868482; https://anzctr.org.au/ACTRN12616000868482.aspx.

Indexed as

DementiaDiet TherapyExerciseFemaleHumansInternet-Based InterventionMaleMiddle AgedPrimary Health CareReferral and ConsultationRisk Reduction Behaviordementia prevention & controlpragmatic clinical trialpreventionprimary careprimary preventionrisk reduction behavior

Identifiers

PMID32969833
PMCPMC7545332
OpenAlexW3047567821

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.