Evidence map›Paper›PMID 32969791›Full record

ArticleeLife2020

MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly.

Meltem Weger, Benjamin D Weger, Andrea Schink, Masanari Takamiya, Johannes Stegmaier, Cédric Gobet, Alice Parisi, Andrei Yu Kobitski, Jonas Mertes, Nils Krone and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Origin, form and function of extraembryonic structures in teleost fishes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 4 countries.

Meltem Weger *Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.ORCID 0000-0002-9452-2373
Benjamin D Weger *Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.ORCID 0000-0002-1831-3561
Andrea SchinkInstitute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.
Masanari TakamiyaInstitute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.
Johannes StegmaierInstitute for Automation and Applied Informatics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.ORCID 0000-0003-4072-3759
Cédric GobetNestlé Institute of Health Sciences SA, EPFL Innovation Park, Lausanne, Switzerland.
Alice ParisiNestlé Institute of Health Sciences SA, EPFL Innovation Park, Lausanne, Switzerland.
Andrei Yu KobitskiInstitute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.
Jonas MertesInstitute of Applied Physics, Karlsruhe Institute of Technology, Karlsruhe, Germany.
Nils KroneInstitute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.
Uwe SträhleInstitute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.
Gerd Ulrich NienhausInstitute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.ORCID 0000-0002-5027-3192
Ralf MikutInstitute for Automation and Applied Informatics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.
Frédéric GachonInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.ORCID 0000-0002-9279-9707
Philipp GutNestlé Institute of Health Sciences SA, EPFL Innovation Park, Lausanne, Switzerland.
Thomas DickmeisInstitute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.ORCID 0000-0002-9819-1962
Karlsruhe Institute of Technology · DEThe University of Queensland · AUUniversity of Birmingham · GB

Funding

Helmholtz-Gemeinschaft BioInterfaces in Technology and Medicine (BIFTM)Helmholtz-Gemeinschaft Science and Technology of Nanostructures (STN)Marie Curie Intra-European Fellowship PIEF-GA-2013-625827
6 · The paper itself

Abstract

The glucose-sensing Mondo pathway regulates expression of metabolic genes in mammals. Here, we characterized its function in the zebrafish and revealed an unexpected role of this pathway in vertebrate embryonic development. We showed that knockdown of

Indexed as

Basic Helix-Loop-Helix Leucine Zipper Transcription FactorsZebrafish ProteinsAnimalsCholesterolEmbryo, NonmammalianGastrulationGene Expression Regulation, DevelopmentalGene Knockdown TechniquesZebrafishBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCholesterolZebrafish Proteinscarbohydrate response elementcholesteroldevelopmental biologyepibolygeneticsgenomicsmetabolismmicrotubulepregnenolonezebrafish

Identifiers

PMID32969791
PMCPMC7515633
OpenAlexW3088049006

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.