Evidence map›Paper›PMID 32969640›Full record

ReviewChemical reviews2020

Asymmetric Catalysis Mediated by Synthetic Peptides, Version 2.0: Expansion of Scope and Mechanisms.

Anthony J Metrano, Alex J Chinn, Christopher R Shugrue, Elizabeth A Stone, Byoungmoo Kim, Scott J Miller

Open access · greenAbstract readReview
In one paragraph

Review in Chemical reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 215 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Enantiopurity-Dependent Peptide Coacervates and Asymmetric Organocatalysis.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  6. Desymmetrization ofJournal of the American Chemical Society · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Emergent Mechanisms in Biocatalysis.ACS central science · 2025
    Review
  16. Article
  17. Review
  18. Article
  19. A glycan that performs catalysis.Nature chemistry · 2025
    Article
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Anthony J MetranoAstraZeneca Oncology R&D, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.ORCID 0000-0002-2599-8917
Alex J ChinnDepartment of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.ORCID 0000-0002-8020-7815
Christopher R ShugrueDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.ORCID 0000-0002-3504-9475
Elizabeth A StoneDepartment of Chemistry, Yale University, P.O. Box 208107, New Haven, Connecticut 06520, United States.ORCID 0000-0002-2253-3452
Byoungmoo KimDepartment of Chemistry, Clemson University, Clemson, South Carolina 29634, United States.ORCID 0000-0002-1428-7896
Scott J MillerDepartment of Chemistry, Yale University, P.O. Box 208107, New Haven, Connecticut 06520, United States.ORCID 0000-0001-7817-1318
Yale University · USAstraZeneca (United States) · USClemson University · USMassachusetts Institute of Technology · USPrinceton University · US

Funding

Site-Selective Catalysis for Bioactive Scaffold DiversificationR35GM132092 · NIGMS · YALE UNIVERSITY · PI Scott J Miller · 2019 to 2026
$6.3M
Enantioselective Catalysis with Radical Intermediates Enabled by Proton-Coupled Electron TransferF32GM128245 · NIGMS · PRINCETON UNIVERSITY · PI METRANO, ANTHONY JOSEPH · 2018 to 2019
$99k
NIGMS NIH HHS F32 GM128245NIGMS NIH HHS R35 GM132092
6 · The paper itself

Abstract

Low molecular weight synthetic peptides have been demonstrated to be effective catalysts for an increasingly wide array of asymmetric transformations. In many cases, these peptide-based catalysts have enabled novel multifunctional substrate activation modes and unprecedented selectivity manifolds. These features, along with their ease of preparation, modular and tunable structures, and often biomimetic attributes make peptides well-suited as chiral catalysts and of broad interest. Many examples of peptide-catalyzed asymmetric reactions have appeared in the literature since the last survey of this broad field in

Indexed as

CatalysisMolecular StructureOxidation-ReductionPeptidesPeptides

Identifiers

PMID32969640
PMCPMC8006536
OpenAlexW3088441241

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.