Evidence map›Paper›PMID 32969474›Full record

ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2021

Associations Between Personality Traits and Cognitive Resilience in Older Adults.

Eileen K Graham, Bryan D James, Kathryn L Jackson, Emily C Willroth, Patricia Boyle, Robert Wilson, David A Bennett, Daniel K Mroczek

Open access · bronzeAbstract read
In one paragraph

Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 4 pooled it
3.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Personality trait and state associations with cognitive functioning and variability in middle-aged and older adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026
    Article
  6. Review
  7. A Taxonomy of Data Synthesis.Personality & social psychology bulletin · 2026
    Article
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  10. Article
  11. Article
  12. Article
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  14. Review
  15. Observational
  16. Personality and Transition From Mild Cognitive Impairment to Normal Cognition vs Dementia.Journal of the American Medical Directors Association · 2024
    Observational
  17. Article
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  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Eileen K GrahamDepartment of Medical Social Sciences, Northwestern University, Chicago, Illinois.
Bryan D JamesRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois.
Kathryn L JacksonDepartment of Medical Social Sciences, Northwestern University, Chicago, Illinois.
Emily C WillrothDepartment of Medical Social Sciences, Northwestern University, Chicago, Illinois.
Patricia BoyleRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois.
Robert WilsonRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois.
Daniel K MroczekDepartment of Medical Social Sciences, Northwestern University, Chicago, Illinois.
Northwestern University · USRush University Medical Center · US

Funding

SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BARNES, LISA L · 1991 to 2020
$49.1M
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4M
PERSONALITY AND WELL BEING TRAJECTORIES IN ADULTHOODR01AG018436 · NIA · PURDUE UNIVERSITY WEST LAFAYETTE · PI MROCZEK, DANIEL K. · 2000 to 2020
$6.7M
Personality prediction of dementia risk and progressionR01AG067622 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MROCZEK, DANIEL K. · 2019 to 2023
$3.2M
Cognitive decline after hospitalization in older adults: predictors and pathogenesisK01AG050823 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI JAMES, BRYAN DAVID · 2015 to 2019
$580k
NIA NIH HHS K01 AG050823NIA NIH HHS P30 AG010161NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG018436NIA NIH HHS R01 AG067622
6 · The paper itself

Abstract

objectivesThe goal of this paper was to examine associations between personality traits and resilience to neuropathologic burden.

methodUsing data from the Religious Orders Study and the Rush Memory and Aging Project, we identified a total of 1,375 participants with personality, cognitive, and post-mortem neuropathology data. We regressed cognition onto pathology and extracted the residuals as an indicator of cognitive resilience. We then modeled the effect of Big Five personality traits on cognitive resilience, adjusting for demographics, APOE status, medical comorbidities, and cognitive activity. The analytic plan was preregistered prior to data access or analysis, and all scripts and outputs are available online.

resultsHigher neuroticism was associated with greater vulnerability to pathology. Results from exploratory analyses suggest that higher conscientiousness was associated with less cognitive decline relative to the amount of pathology, or greater resilience. Education and cognitive activity did not moderate these associations. DISCUSSION: Personality may have a pathoplastic effect on neuropathology, as low neuroticism and high conscientiousness are associated with better function despite neuropathologic burden.

Indexed as

AgedAged, 80 and overAgingAutopsyCognitive DysfunctionCognitive ReserveFemaleHumansIndividualityLongitudinal StudiesMaleNeuroticismPersonalityBig Five personalityCognitive resilienceIndividual differencesNeuropathologyPreregistration

Identifiers

PMID32969474
PMCPMC8574296
OpenAlexW2987817919

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.