ArticleJournal of the American Heart Association2020
Predictors of Bleeding in the Perioperative Anticoagulant Use for Surgery Evaluation Study.
Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06844227 (Perioperative Anticoagulant Use for Surgery Evaluation -Virtual Visit), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Perioperative Anticoagulant Use for Surgery Evaluation -Virtual Visit (PAUSE-Virtual), a Simple Perioperative Anticoagulant Management Approach, Replacing a Resource-intensive In-person Doctor-patient Consultation, With a Simple Virtual Care Model That Will Provide a New Standard of Care for Patients on a Direct Oral Anticoagulant or Warfarin and Require Elective Surgery/Procedure.
Who cites it
21 citing papers in PubMed, 52 citations in OpenAlex.
- Perioperative Management of Anticoagulation in Patients With Mechanical Heart Valves.JAMA network open · 2026Article
- Definition, analysis, reporting, and interpretation of perioperative bleeding in randomized controlled trials: a methodological systematic review.Perioperative medicine (London, England) · 2026Review
- Navigating the pause-patient experiences with perioperative anticoagulation interruption: a qualitative study.Research and practice in thrombosis and haemostasis · 2026Article
- Perioperative management of direct oral anticoagulant-treated patients who need urgent surgery.Research and practice in thrombosis and haemostasis · 2026Article
- Temporary Discontinuation and Restarting of Oral Anticoagulants for Neurological and Cardiac Indications.Deutsches Arzteblatt international · 2026Review
- Direct Oral Anticoagulant Levels at Time of Elective Surgery.JAMA network open · 2026Article
- Article
- Perioperative Bleeding Risk and Associated Factors in End-Stage Kidney Disease Patients Undergoing Intertrochanteric Fracture Surgery: Implications for Management.Orthopedic research and reviews · 2026Article
- Time to integrate measurement uncertainty in method comparison and interpretation of hemostasis laboratory assays.Research and practice in thrombosis and haemostasis · 2025Article
- Reversal of direct oral anticoagulants: guidance from the SSC of the ISTH: comment.Journal of thrombosis and haemostasis : JTH · 2025Article
- How to undertake procedures while on antiplatelet agents: a hematologist's view.Research and practice in thrombosis and haemostasis · 2024Review
- Article
- Article
- Direct oral anticoagulants and venous malformations: literature review and retrospective study of 29 patients.Research and practice in thrombosis and haemostasis · 2024Article
- Anticoagulation Stewardship to Bridge the Implementation Gap in Perioperative Anticoagulation Management.TH open : companion journal to thrombosis and haemostasis · 2024Review
- Perioperative Anticoagulation in Patients with Cancer.Current oncology reports · 2023Review
- Pharmacokinetics of Direct Oral Anticoagulants in Emergency Situations: Results of the Prospective Observational RADOA-Registry.Thrombosis and haemostasis · 2022Observational
- Management of DOAC in Patients Undergoing Planned Surgery or Invasive Procedure: Italian Federation of Centers for the Diagnosis of Thrombotic Disorders and the Surveillance of the Antithrombotic Therapies (FCSA) Position Paper.Thrombosis and haemostasis · 2022Article
- The value and limitations of new oral anticoagulant plasma level assessments.European heart journal supplements : journal of the European Society of Cardiology · 2022Article
- Effect of Direct Oral Anticoagulant, Patient, and Surgery Characteristics on Clinical Outcomes in the Perioperative Anticoagulation Use for Surgery Evaluation Study.TH open : companion journal to thrombosis and haemostasis · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
Abstract
Background In the PAUSE (Perioperative Anticoagulant Use for Surgery Evaluation) Study, a simple, standardized, perioperative interruption strategy was provided for patients with nonvalvular atrial fibrillation taking direct oral anticoagulants (DOACs). Our objective was to define the factors associated with perioperative bleeding. Methods and Results We analyzed bleeding as the composite of major and clinically relevant nonmajor bleeding. Putative predictors of bleeding, and preoperative DOAC level were prospectively collected during recruitment. We used stratified logistic regression models for analysis. All statistical analyses were performed in R version 3.6.0. There were 3007 patients requiring perioperative DOAC interruption. More than one third of the included patients underwent a high bleeding risk procedure. The 30-day rates of major and clinically relevant nonmajor bleeding were 3.02% in apixaban (n=1257), 2.84% in dabigatran (n=668), and 4.16% for rivaroxaban (n=1082). Multivariate analysis stratified by region found more bleeding for hypertension (odds ratio [OR], 1.79; 95% CI 1.07-2.99;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.