SynthesisAmerican journal of reproductive immunology (New York, N.Y. : 1989)2020
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and its effect on gametogenesis and early pregnancy.
Synthesis in American journal of reproductive immunology (New York, N.Y. : 1989), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- COVID-19 and pregnancy: An umbrella review of clinical presentation, vertical transmission, and maternal and perinatal outcomes.PloS one · 2021Pooled it
- Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and its effect on gametogenesis and early pregnancy.American journal of reproductive immunology (New York, N.Y. : 1989) · 2020Pooled it
- Update on andrological effects of SARS-CoV-2 infection and COVID-19: An overview review.Andrology · 2025Review
- COVID-19 and Oncofertility: No SARS-CoV-2 in Semen but Inflammation Seems to Affect Sperm Parameters.Journal of medical virology · 2024Article
- Epidemiology, clinical presentation, pathophysiology, and management of long COVID: an update.Molecular psychiatry · 2023Review
- Neuronal progenitors of the dentate gyrus express the SARS-CoV-2 cell receptor during migration in the developing human hippocampus.Cellular and molecular life sciences : CMLS · 2023Article
- Relationship between covid-pandemic anxiety and sleep disorder with menstrual disorders among female medical workers.BMC women's health · 2023Article
- Review
- Impact of COVID-19 convalescence on pregnancy outcomes in patients undergoing IVF/ICSI during fresh ART cycles: a retrospective cohort study.Frontiers in endocrinology · 2023Article
- SARS-CoV-2 infection and COVID-19 and human reproduction - A changing perspective - A 2022 update.Clinics (Sao Paulo, Brazil) · 2023Article
- COVID-19 infection and vaccine have no impact on in-vitro fertilization (IVF) outcome.Scientific reports · 2022Article
- COVID-19, Vaccination, and Female Fertility in the Czech Republic.International journal of molecular sciences · 2022Article
- Covid-19 and its implications for the provision of gynecological services globally.European journal of obstetrics, gynecology, and reproductive biology · 2022Article
- Associations and Disease-Disease Interactions of COVID-19 with Congenital and Genetic Disorders: A Comprehensive Review.Viruses · 2022Review
- Post-COVID-19 menstrual abnormalities and infertility: Repercussions of the pandemic.Journal of education and health promotion · 2022Review
- Is there impact of the SARS-CoV-2 pandemic on steroidogenesis and fertility?Physiological research · 2021Review
- Mild COVID-19 infection does not alter the ovarian reserve in women treated with ART.Reproductive biomedicine online · 2021Observational
- Investigating the impact of asymptomatic or mild SARS-CoV-2 infection on female fertility andEClinicalMedicine · 2021Article
- Current systematic reviews and meta-analyses of COVID-19.World journal of virology · 2021Article
- Effect of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) on reproductive system.Stem cell research · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
SARS-CoV-2 infection and pregnancy has been the topic of hundreds of publications over the last several months; however, few studies have focused on the implications of infection in early pregnancy and reproductive tissues. Here, we analyzed available evidence pertaining to SARS-CoV-2 infection, in early pregnancy, and in reproductive tissues. We searched PubMed and Embase databases in accordance with guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) for publications from inception to June 4, 2020. Four reviewers screened titles and abstracts and obtained full-text articles for analysis. Sixty-two studies were included in the review. Biological plausibility for infection with SARS-CoV-2 exists in testis, ovaries, and placenta as they express ACE2 receptor activity. In males, SARS-CoV-2 infection could lead to functional abnormalities leading to spermatogenic failure and male infertility. In females, an alteration of the ACE2 cascade via SARS-CoV-2 infection could lead to impairment in important follicular and luteal processes. There is also evidence of significant placental pathology in SARS-CoV-2 infection, but it is unclear what effects there may be for early pregnancy, though available data suggest less severe effects compared to other respiratory virus outbreaks. Further investigation is needed regarding SARS-CoV-2 in reproductive function and early pregnancy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.