Evidence map›Paper›PMID 32969062›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2020

STING controls intestinal homeostasis through promoting antimicrobial peptide expression in epithelial cells.

Yanbo Yu, Wenjing Yang, Anthony J Bilotta, Yu Yu, Xiaojing Zhao, Zheng Zhou, Suxia Yao, Jimin Xu, Jia Zhou, Sara M Dann and 2 more

Open access · greenAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Review
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  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Protective role of cGAS in NASH is related to the maintenance of intestinal homeostasis.Liver international : official journal of the International Association for the Study of the Liver · 2023
    Article
  15. The Many Ways to Deal with STING.International journal of molecular sciences · 2023
    Review
  16. Article
  17. Potential Therapeutic Value of the STING Inhibitors.Molecules (Basel, Switzerland) · 2023
    Review
  18. Intrinsic STING Switches off Pathogenetic Programs of Th1 Cells to Inhibit Colitis.Cellular and molecular gastroenterology and hepatology · 2023
    Article
  19. STING Signaling and Sterile Inflammation.Frontiers in immunology · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Yanbo YuDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Wenjing YangDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Anthony J BilottaDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Yu YuDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Xiaojing ZhaoDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Zheng ZhouDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Suxia YaoDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Jimin XuChemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.
Jia ZhouChemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.
Sara M DannDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
Yanqing LiDepartment of Gastroenterology, Qilu Hospital, Shandong University, Jinan, P.R. China.
Yingzi CongDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
The University of Texas Medical Branch at Galveston · USQilu Hospital of Shandong University · CN

Funding

Th17-IgA Axis in Regulation of Intestinal InflammationR01DK105585 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CONG, YINGZI · 2016 to 2020
$1.8M
GPR120 regulation of inflammatory bowel diseaseR01DK125011 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CONG, YINGZI · 2020 to 2022
$1.5M
Microbiota metabolites, GPR, and inflammatory bowel diseasesR01DK112436 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CONG, YINGZI · 2017 to 2020
$1.4M
GPR120 regulation of intestinal IgA responses and gut IgA-coated bacteriaR21AI150210 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SUN, JIAREN · 2020 to 2021
$435k
NIAID NIH HHS R21 AI150210NIDDK NIH HHS R01 DK105585NIDDK NIH HHS R01 DK112436NIDDK NIH HHS R01 DK125011
6 · The paper itself

Abstract

Stimulator of interferon genes (STING) has been shown to play a critical role in orchestrating immune responses to various pathogens through sensing cyclic dinucleotides. However, how STING regulates intestinal homeostasis is still not completely understood. In this study, we found that STING

Indexed as

AnimalsCitrobacter rodentiumColitisEnterobacteriaceae InfectionsEpithelial CellsHomeostasisImmunity, InnateInflammationIntestinal MucosaMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutPancreatitis-Associated ProteinsPore Forming Cytotoxic ProteinsSTING ProteinMembrane ProteinsPancreatitis-Associated ProteinsPore Forming Cytotoxic ProteinsReg3g protein, mouseSting1 protein, mouseSTING ProteinIECintestinal homeostasisREG3γSTING

Identifiers

PMID32969062
PMCPMC7606834
OpenAlexW3088371550

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.