Evidence map›Paper›PMID 32968929›Full record

ReviewBiogerontology2021

ATP-dependent chromatin remodelers in ageing and age-related disorders.

Pynskhem Bok Swer, Ramesh Sharma

Abstract readReview
PubMed Publisher
In one paragraph

Review in Biogerontology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
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  6. Article
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  10. Chromatin: the old and young of it.Frontiers in molecular biosciences · 2023
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Pynskhem Bok SwerDepartment of Biochemistry, North-Eastern Hill University, Shillong, 793022, India.
Ramesh SharmaDepartment of Biochemistry, North-Eastern Hill University, Shillong, 793022, India. sharamesh@gmail.com.ORCID 0000-0002-1574-8930
North Eastern Hill University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ageing is characterized by the perturbation in cellular homeostasis associated with genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion and altered intracellular communication. Changes in the epigenome represent one of the crucial mechanisms during ageing and in age-related disorders. The ATP-dependent chromatin remodelers are an evolutionarily conserved family of nucleosome remodelling factors and generally regulate DNA repair, replication, recombination, transcription and cell cycle. Here, we review the chromatin based epigenetic changes that occur in ageing and age-related disorders with a specific reference to chromatin remodelers. We also discuss the link between dietary restriction and chromatin remodelers in regulating age-related processes with a view for consideration in future intervention studies.

Indexed as

AgingChromatinAdenosine TriphosphateCellular SenescenceChromatin Assembly and DisassemblyGenomic InstabilityHumansAdenosine TriphosphateChromatinAgeingChromatin remodelersDietary restrictionEpigenetics

Identifiers

PMID32968929
OpenAlexW3088192027

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.