Evidence map›Paper›PMID 32968928›Full record

ArticleCellular and molecular neurobiology2021

LncRNA HOTAIR Promotes Neuronal Damage Through Facilitating NLRP3 Mediated-Pyroptosis Activation in Parkinson's Disease via Regulation of miR-326/ELAVL1 Axis.

Qian Zhang, Xiao-Mo Huang, Jian-Xiong Liao, Yu-Kang Dong, Jiang-Lan Zhu, Cun-Cun He, Jia Huang, Yao-Wei Tang, Dan Wu, Jin-Yong Tian

Open access · greenAbstract read
In one paragraph

Article in Cellular and molecular neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 65 citations in OpenAlex.

  1. Article
  2. Brain-muscle axis regulation of neuroinflammation and sarcopenia in Parkinson's disease: the bridging role of lactylation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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  14. The multifaceted functions of long non-coding RNAExpert reviews in molecular medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Qian ZhangDepartment of Emergency, Guizhou Province, Guizhou Provincial People's Hospital, No. 83, Zhongshan East Road, Guiyang, 550002, P.R. China.ORCID http://orcid.org/0000-0002-5977-7071
Xiao-Mo HuangDepartment of Emergency, Guizhou Province, Guizhou Provincial People's Hospital, No. 83, Zhongshan East Road, Guiyang, 550002, P.R. China.ORCID http://orcid.org/0000-0002-2055-6538
Jian-Xiong LiaoDepartment of Emergency, Guizhou Province, Guizhou Provincial People's Hospital, No. 83, Zhongshan East Road, Guiyang, 550002, P.R. China.ORCID http://orcid.org/0000-0003-4144-7370
Yu-Kang DongDepartment of Emergency, Guizhou Province, Guizhou Provincial People's Hospital, No. 83, Zhongshan East Road, Guiyang, 550002, P.R. China.ORCID http://orcid.org/0000-0002-2557-9384
Jiang-Lan ZhuDepartment of Emergency, Guizhou Province, Guizhou Provincial People's Hospital, No. 83, Zhongshan East Road, Guiyang, 550002, P.R. China.ORCID http://orcid.org/0000-0001-7994-5450
Cun-Cun HeDepartment of Emergency, Guizhou Province, Guizhou Provincial People's Hospital, No. 83, Zhongshan East Road, Guiyang, 550002, P.R. China.ORCID http://orcid.org/0000-0002-7276-7505
Jia HuangDepartment of Emergency, Guizhou Province, Guizhou Provincial People's Hospital, No. 83, Zhongshan East Road, Guiyang, 550002, P.R. China.ORCID http://orcid.org/0000-0002-3818-2706
Yao-Wei TangDepartment of Emergency, Guizhou Province, Guizhou Provincial People's Hospital, No. 83, Zhongshan East Road, Guiyang, 550002, P.R. China.ORCID http://orcid.org/0000-0003-3218-9963
Dan WuDepartment of Emergency, Guizhou Province, Guizhou Provincial People's Hospital, No. 83, Zhongshan East Road, Guiyang, 550002, P.R. China.ORCID http://orcid.org/0000-0002-7230-1297
Jin-Yong TianDepartment of Emergency, Guizhou Province, Guizhou Provincial People's Hospital, No. 83, Zhongshan East Road, Guiyang, 550002, P.R. China. jytian@gzu.edu.cn.ORCID http://orcid.org/0000-0001-5369-6302
Guizhou Provincial People's Hospital · CN

Funding

Doctor Foundation of Guizhou Provincial People's Hospital No. GZSYBS[2015]03Natural Science Foundation of China No. 81560201
6 · The paper itself

Abstract

Parkinson's disease (PD) seriously threatens human's health. Researches have shown a close correlation between long non-coding RNAs (lncRNAs) and PD. However, the biological function of lncRNA homeobox transcript antisense RNA (HOTAIR) in PD remains largely unknown. In this study, we established PD models in vivo and in vitro by using 1-methyl-4-phenyl-2, 3, 6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium (MPP

Indexed as

1-Methyl-4-phenylpyridiniumAnimalsCell Line, TumorDose-Response Relationship, DrugELAV-Like Protein 1HumansMaleMiceMice, Inbred C57BLMicroRNAsNeuronsNLR Family, Pyrin Domain-Containing 3 ProteinParkinsonian DisordersPyroptosisRNA, Long Noncoding1-Methyl-4-phenylpyridiniumElavl1 protein, mouseELAV-Like Protein 1HOTAIR long non-coding RNA, mouseMicroRNAsMIRN326 microRNA, mouseNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseRNA, Long NoncodingELAVL1LncRNA HOTAIRmiR-326NLRP3Parkinson’s diseasePyroptosis

Identifiers

PMID32968928
PMCPMC11444004
OpenAlexW3088428078

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.