Evidence map›Paper›PMID 32968868›Full record

ArticlePharmaceutical research2020

Preparation and Evaluation of Cubosomes/Cubosomal Gels for Ocular Delivery of Beclomethasone Dipropionate for Management of Uveitis.

Sherif A Gaballa, Omar H El Garhy, Hossam Moharram, Hamdy Abdelkader

Abstract read
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In one paragraph

Article in Pharmaceutical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 64 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sherif A GaballaDepartment of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt.
Omar H El GarhyDepartment of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt.
Hossam MoharramDepartment of Ophthalmology, Faculty of Medicine, Minia University, Minia, Egypt.
Hamdy AbdelkaderDepartment of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt. h.abdelkader@mu.edu.eg.
Minia University · EGDeraya University

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTopical corticosteroids administration is commonly used for management of various ocular conditions especially those affecting the anterior segment of the eye. Poor solubility and limited pre-corneal residence time result in insufficient drug penetration to the outer (cornea and conjunctival-scleral) coats of the eye. This study aimed to prepare and evaluate cubosomes for prolonging residence time and enhancing ocular bioavailability of BDP.

methodsGMO-cubosomes were prepared using the top-down technique. Two stabilizers were investigated: poloxamer 407 and solulan C24. Particle size, EE %, polarized-light microscopy, TEM, in vitro release, transcorneal permeation, BCOP, histopathology and in vivo evaluation for treatment of uveitis in a rabbits' model were studied.

resultsThe prepared cubosomes were of nano-sizes (100 nm - 278 nm); EE% was around 94%. The cubosomes were confirmed by visualizing the "Maltese crosses" textures. Transcorneal permeation was significantly (p < 0.05) improved, compared to BDP-suspension (the control formulation). The optimized cubosomes F1P was incorporated in CMC gel (Cubo-gel). The prepared Cubo-gel formulations showed better rheological characteristics and high ocular tolerability. Superior anti-inflammatory properties were recorded for the Cubo-gel for treatment of endotoxin-induced uveitis in the rabbit model when compared to the control BDP-suspension.

conclusionsTranscorneal permeation parameters P

Indexed as

Administration, TopicalAnimalsBeclomethasoneBiological AvailabilityCattleDrug CarriersDrug CompoundingDrug Delivery SystemsEyeGelsOcular AbsorptionRabbitsUveitisBeclomethasoneDrug CarriersGelsBCOP assaybeclomethasone dipropionateCubosomesocular drug deliveryresidence timeuveitis

Identifiers

PMID32968868
OpenAlexW3087809905

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.