Evidence map›Paper›PMID 32968788›Full record

ArticleAmerican journal of hypertension2021

Current Smoking Raises Risk of Incident Hypertension: Hispanic Community Health Study-Study of Latinos.

Robert C Kaplan, Pedro L Baldoni, Garrett M Strizich, Eliseo J Pérez-Stable, Nancy L Saccone, Carmen A Peralta, Krista M Perreira, Marc D Gellman, Jessica S Williams-Nguyen, Carlos J Rodriguez and 6 more

Abstract read
In one paragraph

Article in American journal of hypertension, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Smoking status among hypertensive patients in Mosul City.Journal of education and health promotion · 2026
    Article
  9. Brazilian Guidelines of Hypertension - 2025.Arquivos brasileiros de cardiologia · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Robert C KaplanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
Pedro L BaldoniDepartment of Biostatistics, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA.
Garrett M StrizichDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
Eliseo J Pérez-StableNational Institute on Minority Health and Health Disparities, Bethesda, Maryland, USA.
Nancy L SacconeDivision of Biology and Biomedical Sciences, Washington University, St. Louis, Missouri, USA.
Carmen A PeraltaDepartment of Medicine, University of California-San Francisco, San Francisco, California, USA.
Krista M PerreiraDepartment of Social Medicine, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA.
Marc D GellmanDepartment of Psychology, University of Miami, Miami, Florida, USA.
Jessica S Williams-NguyenPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Carlos J RodriguezDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
David J LeeDepartment of Public Health Sciences, University of Miami, Coral Gables, Florida, USA.
Martha DaviglusDepartment of Medicine, University of Illinois-Chicago, Chicago, Illinois, USA.
Gregory A TalaveraSchool of Public Health, San Diego State University, San Diego, California, USA.
James P LashDepartment of Medicine, University of Illinois-Chicago, Chicago, Illinois, USA.
Jianwen CaiDepartment of Biostatistics, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA.
Nora FranceschiniDepartment of Epidemiology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA.

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KATHERINE A. HOADLEY · 2001 to 2026
$36.3M
Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
Program Development (Pilot) CoreP30AG066615 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ELIZABETH A FRANKENBERG · 2020 to 2026
$4.1M
Leveraging ancestry to map kidney lociR01MD012765 · NIMHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRANCESCHINI, NORA · 2017 to 2021
$3.6M
Genetics of kidney disease in diverse populationsR01DK117445 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRANCESCHINI, NORA · 2018 to 2022
$2.7M
Trans-ethnic meta-analysis of blood pressure in African and European ancestriesR21HL123677 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRANCESCHINI, NORA · 2014 to 2015
$242k
Phenome-wide association of protein function-altering variants in a family studyR21HL140385 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRANCESCHINI, NORA · 2017 to 2018
$229k
HISPANIC COMMUNITY HEALTH STUDY-268065233N01HC065233 · HC · COORDINATING CENTER · PI CHAMBLESS, LLOYD E · 2006 to 2006
–
NHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NHLBI NIH HHS R21 HL123677NHLBI NIH HHS R21 HL140385NICHD NIH HHS P2C HD050924NIDDK NIH HHS R01 DK117445NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P30 ES027792NIMHD NIH HHS R01 MD012765
6 · The paper itself

Abstract

backgroundHypertension has been implicated as a smoking-related risk factor for cardiovascular disease but the dose-response relationship is incompletely described. Hispanics, who often have relatively light smoking exposures, have been understudied in this regard.

methodsWe used data from a 6-year follow-up study of US Hispanic adults aged 18-76 to address the dose-response linking cigarette use with incident hypertension, which was defined by measured blood pressure above 140/90 mm Hg or initiation of antihypertensive medications. Adjustment was performed for potential confounders and mediators, including urinary albumin-to-creatinine ratio which worsened over time among smokers.

resultsCurrent smoking was associated with incident hypertension, with a threshold effect above 5 cumulative pack-years of smoking (vs. never smokers, hazard ratio for hypertension [95% confidence interval] of 0.95 [0.67, 1.35] for 0-5 pack-years, 1.47 [1.05, 2.06] for 5-10 pack-years, 1.40 [1.00, 1.96] for 10-20 pack-years, and 1.34 [1.09, 1.66] for ≥20 pack-years, P = 0.037). In contrast to current smokers, former smokers did not appear to have increased risk of hypertension, even at the highest cumulative pack-years of past exposure.

conclusionsThe results confirm that smoking constitutes a hypertension risk factor in Hispanic adults. A relatively modest cumulative dose of smoking, above 5 pack-years of exposure, raises risk of hypertension by over 30%. The increased hypertension risk was confined to current smokers, and did not increase further with higher pack-year levels. The lack of a smoking-hypertension association in former smokers underscores the value of smoking cessation.

Indexed as

Hispanic or LatinoHypertensionSmokingAdolescentAdultAgedFollow-Up StudiesHumansIncidenceMiddle AgedRisk FactorsYoung Adultblood pressurechronic kidney diseaseepidemiologyhypertensionlongitudinal studyprospective cohort studysmoking

Identifiers

PMID32968788
PMCPMC7951044

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.