ArticlePakistan journal of medical sciences
Study on the changes in TSH, TPO-Ab and other indicators due to Vitamin D deficiency in Pregnant Women with subclinical hypothyroidism in the first trimester.
Article in Pakistan journal of medical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Efficacy of Vitamin-D supplementation in improving the prognosis of H-type hypertension in elderly patients.Pakistan journal of medical sciences · 2024Article
- Effect of Vitamin-D on Glycemic Parameters and Adiponectin in gestational diabetes.Pakistan journal of medical sciences · 2024Article
- Gut microbiome characteristics of women with hypothyroidism during early pregnancy detected by 16S rRNA amplicon sequencing and shotgun metagenomic.Frontiers in cellular and infection microbiology · 2024Article
- The Interactive Effects of Severe Vitamin D Deficiency and Iodine Nutrition Status on the Risk of Thyroid Disorder in Pregnant Women.Nutrients · 2022Article
- Predicting Elevated TSH Levels in the Physical Examination Population With a Machine Learning Model.Frontiers in endocrinology · 2022Article
- Association between gestational blood lipids and TSH levels and pregnancy outcome of patients with subclinical hypothyroidism.Pakistan journal of medical sciencesArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the effect of vitamin D deficiency on the levels of thyroid stimulating hormone (TSH), thyroid peroxidase antibody (TPO-Ab), interleukin-1 (IL-1) and high-sensitivity C-reactive protein (hs-CRP) in pregnant women with early pregnancy complicated by subclinical hypothyroidism.
methodsA total of 172 pregnant women with subclinical hypothyroidism in the first trimester diagnosed and treated in a given hospital from August 2014 to May 2018 were selected, and their levels of vitamin D were determined. Depending on the abnormality of their vitamin D levels, the study participants were divided into two groups: the study group (vitamin D≤20 ng/L) and the control group (vitamin D>20 ng/L). The levels of TSH, TPO-Ab, IL-1 and hsCRP in the two groups were measured.
resultsThe levels of TSH, hsCRP and TPO-Ab in the study group were significantly higher than those in the control group (P<0.05). The comparison between the two groups in terms of IL-1 showed no statistically significant difference.
conclusionVitamin D deficiency in the first trimester is associated with in an increased level of TSH in the first trimester, thereby aggravating subclinical hypothyroidism. The mechanism may be associated with the impact of vitamin D deficiency on hs-CRP and other body inflammation indicators, as well as on thyroid autoantibodies and other immune indicators, but has no effect on IL-1 levels.
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