ArticleNature2020
Synthetic group A streptogramin antibiotics that overcome Vat resistance.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.
- Predicting Antibiotic Resistance inInternational journal of molecular sciences · 2025Pooled it
- Structure-based design and synthesis of group A streptogramins that bind to the nascent peptide exit tunnel of the ribosome.European journal of medicinal chemistry · 2026Article
- An unattended image-processing pipeline for on-the-fly quality assessment and 3D exploration in cryo-EM.Acta crystallographica. Section D, Structural biology · 2026Article
- Metabolism-Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Article
- A cost-effective 200 kV cryo-EM core facility for high resolution single particle analysis.Methods in microscopy · 2026Article
- Evolution of a Strategy for the Unified Synthesis of Enteropeptin Sactipeptides.The Journal of organic chemistry · 2026Article
- Structural modification of oxazolidinone antibiotics alters nascent peptide stalling preference and peptide trajectory through the ribosome.bioRxiv : the preprint server for biology · 2026Article
- Biosynthesis and Synthesis of Griseoviridin and Viridogrisein.Synthesis · 2026Article
- On the Completeness of Existing RNA Fragment Structures.Genomics, proteomics & bioinformatics · 2025Article
- Initial leads to combat streptogramin resistance generated from X-ray fragment screening against VatD.Structure (London, England : 1993) · 2025Article
- Hybrid Antibiotics Targeting the Bacterial Ribosome.ACS central science · 2025Article
- Co-cultivation of Lactobacillus acidophilus and Bacillus subtilis mediates the gut-muscle axis affecting pork quality and flavor.Journal of animal science and biotechnology · 2025Article
- A large-scale curated and filterable dataset for cryo-EM foundation model pre-training.Scientific data · 2025Article
- Docking 14 Million Virtual Isoquinuclidines against the μ and κ Opioid Receptors Reveals Dual Antagonists-Inverse Agonists with Reduced Withdrawal Effects.ACS central science · 2025Article
- Cationic antimicrobial peptide CC34 potential anticancer and apoptotic induction on cancer cells.Amino acids · 2025Article
- Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research.Angewandte Chemie (International ed. in English) · 2025Review
- Docking 14 million virtual isoquinuclidines against the mu and kappa opioid receptors reveals dual antagonists-inverse agonists with reduced withdrawal effects.bioRxiv : the preprint server for biology · 2025Article
- HNature communications · 2024Article
- Computer-aided drug design to generate a unique antibiotic family.Nature communications · 2024Article
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Authors and funding
22 authors at 4 institutions in 3 countries.
Qi Li *Department of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
Jenna Pellegrino *Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-6212-395X
D John LeeDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.
Arthur A TranDepartment of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
Hector A ChairesDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-8493-4489
Ruoxi WangDepartment of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-4275-1518
Jesslyn E ParkDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.
Kaijie JiDepartment of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
David ChowDepartment of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
Na ZhangDepartment of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
Axel F BrilotDepartment of Biochemistry and Biophysics and Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, USA.
Justin T BielDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.
Gydo van ZundertSchrödinger, New York, NY, USA.
Kenneth BorrelliDepartment of Biochemistry and Biophysics and Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, USA.
Dean ShinabargerMicromyx, Kalamazoo, MI, USA.
Cindy WolfeMicromyx, Kalamazoo, MI, USA.
Beverly MurrayMicromyx, Kalamazoo, MI, USA.
Matthew P JacobsonDepartment of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6262-655X
Estelle MühleCollection de l'Institut Pasteur (CIP), Microbiology Department, Institut Pasteur, Paris, France.ORCID http://orcid.org/0000-0003-1107-4382
Olivier ChesneauCollection de l'Institut Pasteur (CIP), Microbiology Department, Institut Pasteur, Paris, France.
James S FraserDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-5080-2859
Ian B SeipleDepartment of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA. ian.seiple@ucsf.edu.ORCID http://orcid.org/0000-0002-8732-1362
University of California, San Francisco · USHoward Hughes Medical Institute · USInstitut Pasteur · FRSchrodinger (United States) · US
Funding
NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9MUser Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS · 2017 to 2026
$28.6MSTRUCTURAL BIOLOGY TRAINING PROGRAMT32GM008284 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KORTEMME, TANJA · 1988 to 2022
$10.1MRESEARCH TRAINING IN CHEMISTRY AND CHEMICAL BIOLOGYT32GM064337 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CRAIK, CHARLES SCOTT · 2002 to 2021
$7.8MEliminating Critical Systematic Errors In Structural Biology With Next-Generation SimulationR01GM124149 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOLTON, JAMES M · 2017 to 2024
$2.5MSupplement to Resolving ensemble averaged conformations by multi-temperature x-ray crystallography - Equipment 2020R01GM123159 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FRASER, JAMES SOLOMON · 2018 to 2021
$2.3MPlatforms for the Synthesis of Bacterial Protein Synthesis InhibitorsR35GM128656 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEIPLE, IAN BASS · 2018 to 2022
$2.1MAcquisition of an electron microscope for high-resolution single particle cryo-EMS10OD021741 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2016 to 2016
$2.0MLinux cluster for near atomic resolution single particle cryo-EMS10OD020054 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2015 to 2015
$456kCryoEM guided enhancement of ribosome-targeting antibioticsF32AI148120 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, DAVID JOHN · 2019 to 2021
$135kHoward Hughes Medical InstituteNIAID NIH HHS F32 AI148120NIGMS NIH HHS P30 GM124169NIGMS NIH HHS R01 GM123159NIGMS NIH HHS R01 GM124149NIGMS NIH HHS R35 GM128656NIGMS NIH HHS T32 GM008284NIGMS NIH HHS T32 GM064337NIGMS NIH HHS U24 GM129539NIH HHS S10 OD020054NIH HHS S10 OD021741
Abstract
Natural products serve as chemical blueprints for most antibiotics in clinical use. The evolutionary process by which these molecules arise is inherently accompanied by the co-evolution of resistance mechanisms that shorten the clinical lifetime of any given class of antibiotics
Indexed as
Drug DesignAcetylationAcetyltransferasesAnimalsAnti-Bacterial AgentsBacterial LoadBinding SitesCryoelectron MicroscopyDrug Resistance, BacterialFemaleIn Vitro TechniquesMiceMicrobial Sensitivity TestsModels, MolecularRibosomesRNA, TransferAcetyltransferasesAnti-Bacterial AgentsRNA, TransferStreptogramin Group AVirginiamycinvirginiamycin acetyltransferase D
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.