ArticleNature chemistry2020
Olanzapine crystal symmetry originates in preformed centrosymmetric solute dimers.
Article in Nature chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Navigating Classical and Nonclassical Realms of Nucleation and Crystallization.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Mechanistic Insights into Molecular Modifiers That Promote Urate Crystallization through Solute Assembly Regulation.JACS Au · 2026Article
- A nonclassical pathway of β-hematin crystal nucleation enables its suppression by antimalarials.Communications chemistry · 2025Article
- Lattice bond chains administer kink anisotropy and inform strategies of theophylline crystal self-healing.iScience · 2025Article
- Direct observation of cholesterol monohydrate crystallization.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A dual growth mode unique for organic crystals relies on mesoscopic liquid precursors.Communications chemistry · 2024Article
- The elementary reactions for incorporation into crystals.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Rational Design of a Self-Assembling High Performance Organic Nanofluorophore for Intraoperative NIR-II Image-Guided Tumor Resection of Oral Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Cinematographic Recording of a Metastable Floating Island in Two- and Three-Dimensional Crystal Growth.ACS central science · 2022Article
- The pathway from the solution to the steps.Journal of crystal growth · 2022Article
- Accounting for the Presence of Molecular Clusters in Modeling and Interpreting Nucleation and Growth.Crystal growth & design · 2022Article
- Frustrated peptide chains at the fibril tip control the kinetics of growth of amyloid-β fibrils.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Continuum Crystallization Model Derived from Pharmaceutical Crystallization Mechanisms.ACS central science · 2021Article
- Crystal forms in pharmaceutical applications: olanzapine, a gift to crystal chemistry that keeps on giving.IUCrJ · 2020Review
- Symmetry in the making.Nature chemistry · 2020Article
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6 authors.
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Abstract
The symmetries of a crystal are notoriously uncorrelated to those of its constituent molecules. This symmetry breaking is typically thought to occur during crystallization. Here we demonstrate that one of the two symmetry elements of olanzapine crystals, an inversion centre, emerges in solute dimers extant in solution prior to crystallization. We combine time-resolved in situ scanning probe microscopy to monitor the crystal growth processes with all-atom molecular dynamics simulations. We show that crystals grow non-classically, predominantly by incorporation of centrosymmetric dimers. The growth rate of crystal layers exhibits a quadratic dependence on the solute concentration, characteristic of the second-order kinetics of the incorporation of dimers, which exist in equilibrium with a majority of monomers. We show that growth by dimers is preferred due to overwhelming accumulation of adsorbed dimers on the crystal surface, where it is complemented by dimerization and expedites dimer incorporation into growth sites.
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