SynthesisCommunications biology2020
A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
4.8field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Assessing the lack of diversity in genetics research across neurodegenerative diseases: A systematic review of the GWAS Catalog and literature.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology.Nature genetics · 2021Pooled it
- Mitochondrial DNA homeostasis: A novel therapeutic target for neurodegenerative diseases.Neural regeneration research · 2026Article
- Neural Organoid Models as a Platform for Studying Disease Mechanisms in Amyotrophic Lateral Sclerosis.Journal of neurochemistry · 2026Review
- Single-nucleus multiomic profiling of the aging mouse substantia nigra reveals conserved gene alterations linked to Parkinson's disease.Genome research · 2026Article
- Integrative Multi-Omics Mendelian Randomization Highlights Causal Autophagy-Related Genes for Amyotrophic Lateral Sclerosis.Brain and behavior · 2026Article
- Classical HLA class II associations with ALS in Kuwait reveal a DR7-DQ2.2 risk haplotype.Frontiers in immunology · 2026Article
- A genome-wide association study identifies the GPM6A locus associated with age at onset in ALS.Communications biology · 2025Article
- Entering the era of precision medicine to treat amyotrophic lateral sclerosis.Molecular neurodegeneration · 2025Review
- Machine learning identified novel players in lipid metabolism, endosomal trafficking, and iron metabolism of the ALS spinal cord.Scientific reports · 2025Article
- Adenosine diphosphate-ribosylation greatly affects proteins function: a focus on neurodegenerative diseases.Frontiers in aging neuroscience · 2025Review
- Assessing the lack of diversity in genetics research across neurodegenerative diseases: a systematic review of the GWAS Catalog and literature.medRxiv : the preprint server for health sciences · 2024Article
- Abnormal Brain Protein Abundance and Cross-tissue mRNA Expression in Amyotrophic Lateral Sclerosis.Molecular neurobiology · 2024Article
- Mutation and clinical analysis of the CLCC1 gene in amyotrophic lateral sclerosis patients from Central South China.Annals of clinical and translational neurology · 2024Article
- A neuron-immune circuit regulates neurodegeneration in the hindbrain and spinal cord of Arf1-ablated mice.National science review · 2023Article
- Genome-wide analyses identify NEAT1 as genetic modifier of age at onset of amyotrophic lateral sclerosis.Molecular neurodegeneration · 2023Article
- Amyotrophic lateral sclerosis: translating genetic discoveries into therapies.Nature reviews. Genetics · 2023Review
- SMN regulates GEMIN5 expression and acts as a modifier of GEMIN5-mediated neurodegeneration.Acta neuropathologica · 2023Article
- Cumulative Genetic Score andNeurology. Genetics · 2023Article
- Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects.Neuron · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
43 authors at 20 institutions in 1 country.
Ryoichi Nakamura *Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.ORCID http://orcid.org/0000-0002-4854-3579
Kazuharu Misawa *Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.ORCID http://orcid.org/0000-0002-6277-4330
Genki Tohnai *Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Masahiro Nakatochi *Division of Data Science, Department of Nursing, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.ORCID http://orcid.org/0000-0002-1838-4837
Sho FuruhashiTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.
Naoki AtsutaDepartment of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Naoki HayashiDepartment of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Daichi YokoiDepartment of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Hazuki WatanabeDepartment of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Hirohisa WatanabeBrain and Mind Research Center, Nagoya University, Nagoya, Aichi, Japan.
Masahisa KatsunoDepartment of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.ORCID http://orcid.org/0000-0001-9453-9311
Yuishin IzumiDepartment of Neurology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Kazuaki KanaiDepartment of Neurology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Nobutaka HattoriDepartment of Neurology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Mitsuya MoritaDivision of Neurology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Akira TaniguchiDepartment of Neurology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
Osamu KanoDivision of Neurology, Department of Internal Medicine, Toho University Faculty of Medicine, Tokyo, Japan.
Masaya OdaDepartment of Neurology, Vihara Hananosato Hospital, Miyoshi, Hiroshima, Japan.
Kazumoto ShibuyaDepartment of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Satoshi KuwabaraDepartment of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Naoki SuzukiDepartment of Neurology, Tohoku University School of Medicine, Sendai, Miyagi, Japan.ORCID http://orcid.org/0000-0001-8880-8554
Masashi AokiDepartment of Neurology, Tohoku University School of Medicine, Sendai, Miyagi, Japan.
Yasuyuki OhtaDepartment of Neurology, Okayama University Graduate School of Medicine, Okayama, Japan.
Toru YamashitaDepartment of Neurology, Okayama University Graduate School of Medicine, Okayama, Japan.ORCID http://orcid.org/0000-0003-3634-5679
Koji AbeDepartment of Neurology, Okayama University Graduate School of Medicine, Okayama, Japan.
Rina HashimotoDepartment of Neurology, National Hospital Organization Higashinagoya National Hospital, Nagoya, Aichi, Japan.
Ikuko AibaDepartment of Neurology, National Hospital Organization Higashinagoya National Hospital, Nagoya, Aichi, Japan.
Koichi OkamotoDepartment of Neurology, Geriatrics Research Institute and Hospital, Maebashi, Gunma, Japan.
Kouichi MizoguchiDepartment of Neurology, National Hospital Organization Shizuoka Medical Center, Shizuoka, Japan.
Kazuko HasegawaDivision of Neurology, National Hospital Organization, Sagamihara National Hospital, Sagamihara, Kanagawa, Japan.
Yohei OkadaDepartment of Neurology, Aichi Medical University, Nagakute, Aichi, Japan.
Tomohiko IshiharaDepartment of Neurology, Brain Research Institute, Niigata University, Niigata, Japan.
Osamu OnoderaDepartment of Neurology, Brain Research Institute, Niigata University, Niigata, Japan.ORCID http://orcid.org/0000-0003-3354-5472
Kenji NakashimaDepartment of Neurology, National Hospital Organization, Matsue Medical Center, Matsue, Shimane, Japan.
Ryuji KajiDepartment of Neurology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.ORCID http://orcid.org/0000-0001-6207-1080
Yoichiro KamataniLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.ORCID http://orcid.org/0000-0001-8748-5597
Shiro IkegawaLaboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan.ORCID http://orcid.org/0000-0003-0316-2147
Yukihide MomozawaLaboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
Michiaki KuboRIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.ORCID http://orcid.org/0000-0002-0095-2322
Noriko IshidaTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.
Naoko MinegishiTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.
Masao NagasakiTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. nagasaki@genome.med.kyoto-u.ac.jp.ORCID http://orcid.org/0000-0002-4292-8785
Gen SobueDepartment of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan. sobueg@aichi-med-u.ac.jp.ORCID http://orcid.org/0000-0003-4769-5922
Nagoya University · JPTohoku University · JPRIKEN Center for Integrative Medical Sciences · JPOkayama University · JPAichi Medical University · JPChiba University · JPFujita Health University · JPHigashi Nagoya National Hospital · JPNiigata University · JPTokushima University · JPAichi Developmental Disability Center · JPFukushima Medical University · JPJichi Medical University · JPJuntendo University · JPKansai Medical University · JPKyoto University · JPMie University · JPNational Hospital Organization · JPNational Sagamihara Hospital · JPShizuoka Medical Center · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amyotrophic lateral sclerosis (ALS) is a devastating progressive motor neuron disease that affects people of all ethnicities. Approximately 90% of ALS cases are sporadic and thought to have multifactorial pathogenesis. To understand the genetics of sporadic ALS, we conducted a genome-wide association study using 1,173 sporadic ALS cases and 8,925 controls in a Japanese population. A combined meta-analysis of our Japanese cohort with individuals of European ancestry revealed a significant association at the ACSL5 locus (top SNP p = 2.97 × 10
Indexed as
Amyotrophic Lateral SclerosisAsian PeopleCase-Control StudiesChinaCoenzyme A LigasesFemaleGenesGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansJapanMalePolymorphism, Single NucleotideWhite PeopleACSL5 protein, humanCoenzyme A Ligases
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.