ArticleScientific reports2020
Higher visit-to-visit total cholesterol variability is associated with lower cognitive function among middle-aged and elderly Chinese men.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Sleep duration is associated with metabolic syndrome in adolescents and children: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Pooled it
- Sleep Duration and the Risk of Metabolic Syndrome in Adults: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Association of Year-to-Year Lipid Variability With Risk of Cognitive Decline and Dementia in Community-Dwelling Older Adults.Neurology · 2025Trial
- Physical activity trajectories and cognitive decline among older adults in China: a longitudinal cohort study.BMC geriatrics · 2025Article
- Trajectories of Cognitive Decline Before and After New-Onset Hypertension.Journal of the American Heart Association · 2025Article
- Association Between Serum Lipid Traits and Cognitive Function in Middle-aged and Elderly Adults: A Longitudinal Study.Current Alzheimer research · 2025Article
- Digital Exclusion and Cognitive Function in Elderly Populations in Developing Countries: Insights Derived From 2 Longitudinal Cohort Studies.Journal of medical Internet research · 2024Article
- Long-Term Visit-to-Visit Blood Pressure Variability and Cognitive Decline Among Patients With Hypertension: A Pooled Analysis of 3 National Prospective Cohorts.Journal of the American Heart Association · 2024Article
- The mediating effect of sleep duration on metabolic syndrome severity in adults: a structural equation modeling approach.BMC endocrine disorders · 2024Article
- Cardiovascular Risk Factors in China.Journal of geriatric cardiology : JGC · 2024Article
- Visit-to-visit variability in multiple biological measurements and cognitive performance and risk of cardiovascular disease: A cohort study.Cerebral circulation - cognition and behavior · 2024Article
- Review
- Trends in cognitive function before and after stroke in China.BMC medicine · 2023Article
- The association between socioeconomic status and health-related quality of life among young and middle-aged maintenance hemodialysis patients: multiple mediation modeling.Frontiers in psychiatry · 2023Article
- Mechanism of Action of Shenerjiangzhi Formulation on Hyperlipidemia Induced by Consumption of a High-Fat Diet in Rats Using Network Pharmacology and Analyses of the Gut Microbiota.Frontiers in pharmacology · 2022Article
- Article
- Exploring the Bidirectional Associations Between Short or Long Sleep Duration and Lower Cognitive Function: A 7-Year Cohort Study in China.Frontiers in aging neuroscience · 2021Article
- Long-Term Increase in Cholesterol Is Associated With Better Cognitive Function: Evidence From a Longitudinal Study.Frontiers in aging neuroscience · 2021Article
- The association of cholesterol levels with memory and memory change over a 14-year period in a US national cohort.Alzheimer's & dementia (New York, N. Y.)Article
- Blood lipids as accessible biomarkers for early dementia risk screening: Bridging diagnostic gaps in resource-limited settings.Journal of Alzheimer's disease reportsReview
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
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Abstract
To examine the prospective associations between total cholesterol (TC) variability and cognitive function in a large sample of Chinese participants aged 45 years and above. A total of 6,377 people who participated in the China Health and Retirement Longitudinal Study (CHARLS) were included. TC variability was defined as the intra-individual standard deviation over two blood tests in CHARLS 2011 and 2015 (Wave 1 and Wave 3). Cognitive function was assessed by a global cognition score, which included three tests: episodic memory, figure drawing and Telephone Interview of Cognitive Status (TICS). Multivariate linear regression models (MRLMs) and generalized estimating equation (GEE) were used to investigate associations between TC variability and cognitive scores. After adjusting for potential confounders, male participants with higher visit-to-visit TC variability showed lower global cognition scores (β = - 0.71, P < 0.001). After further adjustment for baseline cognition, the association remained statistically significant (β = - 0.68, P < 0.001). The domains with declines were focused on episodic memory (β = - 0.22, P = 0.026) and TICS (β = - 0.44, P = 0.004). However, these associations were not found in women (β = - 0.10, P = 0.623). For men, the rates of decline in global cognition increased by 0.14 (β = - 0.14, P = 0.009) units per year while TC variability increased by 1 mmol/L. For males, higher visit-to-visit TC variability correlated with lower cognitive function and an increased rate of decreases in memory. More attention should be paid to cognitive decline in males with high TC variability, and particularly, on decreases in memory, calculation, attention and orientation.
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