ArticleScientific reports2020
Prospective associations of the infant gut microbiome and microbial function with social behaviors related to autism at age 3 years.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Perturbations in gut microbiota in autism spectrum disorder: a systematic review.Frontiers in neuroscience · 2025Pooled it
- Maternal Prenatal Stress and the Offspring Gut Microbiome: A Cross-Species Systematic Review.Developmental psychobiology · 2025Pooled it
- Parental gut microbiota dysbiosis is associated with cross-generationally shared DNA methylation patterns and autism-like behaviors in offspring.NPJ biofilms and microbiomes · 2026Article
- The relationship between the gut microbiota and neuropsychological development and behaviour during childhood and adolescence: a systematic review of epidemiological studies.Brain, behavior, & immunity - health · 2026Review
- Development of the Gut Microbiota throughout the First Year of Life and Its Association with Socio-Emotional Development into Childhood.Developmental neuroscience · 2026Article
- The microbiota-gut-brain axis as a modulator of symptom expression in autism spectrum disorder, with exploratory insights into ADHD: evidence from a structured narrative review on paediatric population.Frontiers in child and adolescent psychiatry · 2026Review
- Gut microbiome dynamics in autism: a prospective nested case-control study demonstrates microbial-clinical associations following rehabilitation interventions.Frontiers in neuroscience · 2026Article
- Cntn4 Gene Deficiency Promotes Autism-Like Phenotypes Associated with Gut Microbiota Perturbations and Gut-Brain Axis Metabolomic Alterations in Mice.Molecular neurobiology · 2025Article
- Integrative multi-omics analysis of autism spectrum disorder reveals unique microbial macromolecules interactions.Journal of advanced research · 2025Article
- Associations between the gut microbiota at one-year and neurodevelopment in children from the SEPAGES cohort.Brain, behavior, & immunity - health · 2025Article
- Early life microbial succession in the gut follows common patterns in humans across the globe.Nature communications · 2025Article
- Associations among rearing environment and the infant gut microbiome with early-life neurodevelopment and cognitive development in a nonhuman primate model (Journal of developmental origins of health and disease · 2025Article
- The associations between gut microbiota and fecal metabolites with intelligence quotient in preschoolers.BMC microbiology · 2024Article
- Patterns of infant fecal metabolite concentrations and social behavioral development in toddlers.Pediatric research · 2024Article
- Prospective association of the infant gut microbiome with social behaviors in the ECHO consortium.Molecular autism · 2024Article
- Article
- A digital twin of the infant microbiome to predict neurodevelopmental deficits.Science advances · 2024Article
- Gut-resident microorganisms and their genes are associated with cognition and neuroanatomy in children.Science advances · 2023Article
- Early-life differences in the gut microbiota composition and functionality of infants at elevated likelihood of developing autism spectrum disorder.Translational psychiatry · 2023Article
- Bacterial Modification of the Association Between Arsenic and Autism-Related Social Behavior Scores.Exposure and health · 2023Article
Corrections and comments
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Authors and funding
5 authors.
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Abstract
The hypothesized link between gut bacteria and autism spectrum disorder (ASD) has been explored through animal models and human studies with microbiome assessment after ASD presentation. We aimed to prospectively characterize the association between the infant/toddler gut microbiome and ASD-related social behaviors at age 3 years. As part of an ongoing birth cohort gut bacterial diversity, structure, taxa, and function at 6 weeks (n = 166), 1 year (n = 158), 2 years (n = 129), and 3 years (n = 140) were quantified with 16S rRNA gene and shotgun metagenomic sequencing (n = 101 six weeks, n = 103 one year). ASD-related social behavior was assessed at age 3 years using Social Responsiveness Scale (SRS-2) T-scores. Covariate-adjusted linear and permutation-based models were implemented. Microbiome structure at 1 year was associated with SRS-2 total T-scores (p = 0.01). Several taxa at 1, 2, and 3 years were associated with SRS-2 performance, including many in the Lachnospiraceae family. Higher relative abundance of Adlercreutzia equolifaciens and Ruminococcus torques at 1 year related to poorer SRS-2 performance. Two functional pathways, L-ornithine and vitamin B6 biosynthesis, were associated with better social skills at 3 years. Our results support potential associations between early-childhood gut microbiome and social behaviors. Future mechanistic studies are warranted to pinpoint sensitive targets for intervention.
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