ArticleScientific reports2020
Roles of the Tol-Pal system in the Type III secretion system and flagella-mediated virulence in enterohemorrhagic Escherichia coli.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
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- Attenuated mutants ofExperimental biology and medicine (Maywood, N.J.) · 2024Article
- Construction and application of the conditionally essential gene knockdown library inApplied and environmental microbiology · 2023Article
- The Tol-Pal system of Acinetobacter baumannii is important for cell morphology, antibiotic resistance and virulence.International microbiology : the official journal of the Spanish Society for Microbiology · 2023Article
- Plant Signals Anticipate the Induction of the Type III Secretion System in Pseudomonas syringae pv.Microbiology spectrum · 2022Article
- Roles of the Tol/Pal System in Bacterial Pathogenesis and Its Application to Antibacterial Therapy.Vaccines · 2022Review
- The role of TolA, TolB, and TolR in cell morphology, OMVs production, and virulence of Salmonella Choleraesuis.AMB Express · 2022Article
- Adsorption of extracellular proteases and pyocyanin produced byCurrent research in microbial sciences · 2022Article
- Diverse Aquatic Animal Matrices Play a Key Role in Survival and Potential Virulence of Non-O1/O139Frontiers in microbiology · 2022Article
- A Macroporous Magnesium Oxide-Templated Carbon Adsorbs Shiga Toxins and Type III Secretory Proteins in EnterohemorrhagicFrontiers in microbiology · 2022Article
- Roles of OmpA in Type III Secretion System-Mediated Virulence of EnterohemorrhagicPathogens (Basel, Switzerland) · 2021Article
- Strategies for Rapid Identification ofFrontiers in cellular and infection microbiology · 2021Article
- Effects of NaCl Concentrations on Growth Patterns, Phenotypes Associated With Virulence, and Energy Metabolism inFrontiers in microbiology · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The Tol-Pal system is a protein complex that is highly conserved in many gram-negative bacteria. We show here that the Tol-Pal system is associated with the enteric pathogenesis of enterohemorrhagic E. coli (EHEC). Deletion of tolB, which is required for the Tol-Pal system decreased motility, secretion of the Type III secretion system proteins EspA/B, and the ability of bacteria to adhere to and to form attaching and effacing (A/E) lesions in host cells, but the expression level of LEE genes, including espA/B that encode Type III secretion system proteins were not affected. The Citrobacter rodentium, tolB mutant, that is traditionally used to estimate Type III secretion system associated virulence in mice did not cause lethality in mice while it induced anti-bacterial immunity. We also found that the pal mutant, which lacks activity of the Tol-Pal system, exhibited lower motility and EspA/B secretion than the wild-type parent. These combined results indicate that the Tol-Pal system contributes to the virulence of EHEC associated with the Type III secretion system and flagellar activity for infection at enteric sites. This finding provides evidence that the Tol-Pal system may be an effective target for the treatment of infectious diseases caused by pathogenic E. coli.
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