ArticleScientific reports2020
Hepatic lipocalin 2 promotes liver fibrosis and portal hypertension.
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Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27citing papers in PubMed
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27 citing papers in PubMed.
- Metainflammation, Mitochondrial Dysfunction, and Organokine Crosstalk: A Central Axis Linking Metabolic Syndrome to Cardiovascular Diseases.International journal of molecular sciences · 2026Review
- Cyclin D1 regulates the hepatic response to feeding: Evidence for non-cell cycle roles in the liver.bioRxiv : the preprint server for biology · 2026Article
- Epidermal PPARγ Signaling as a Suppressor of Toll-like Receptor-Mediated Inflammation and Fibrosis: Relevance to Cutaneous Squamous Cell Carcinoma.International journal of molecular sciences · 2026Article
- Tumor-derived lactate fuels the STAT3-LCN2 pathway to promote bladder cancer malignancy and chemoresistance.Scientific reports · 2025Article
- EGFRvIII-driven microenvironmental fibroblast activation and transformation accelerate oral cancer progression via lipocalin-2/STAT3 axis.Neoplasia (New York, N.Y.) · 2025Article
- Pantothenic acid ameliorates hepatic fibrosis by targeting IGFBP6 to regulate the TGF-β/SMADs pathway.Communications biology · 2025Article
- Autocrine GDF10 Inhibits Hepatic Stellate Cell Activation via BMPR2/ALK3 Receptor to Prevent Liver Fibrosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Biliary Metaplasia and Macrophage Activation Define the Cellular Landscape of Cardiogenic Liver Disease.JACC. Basic to translational science · 2025Article
- NOS inhibition sensitizes metaplastic breast cancer to PI3K inhibition and taxane therapy via c-JUN repression.Nature communications · 2024Article
- Interrelationships among metabolic syndrome, bone-derived cytokines, and the most common metabolic syndrome-related diseases negatively affecting bone quality.Diabetology & metabolic syndrome · 2024Review
- LCN2 depletion aggravates sepsis-induced liver injury by regulating PTGS2-dependent ferroptosis.International journal of medical sciences · 2024Article
- Innovative angiography: a new approach to discover more hepatic vein collaterals in patients with cirrhotic portal hypertension.BMC gastroenterology · 2023Article
- Lipocalin-2 Secreted by the Liver Regulates Neuronal Cell Function Through AKT-Dependent Signaling in Hepatic Encephalopathy Mouse Model.Clinical nutrition research · 2023Article
- Portal Hypertension in Alcohol-Associated Hepatitis.Current hepatology reports · 2023Review
- Danshensu attenuated lipopolysaccharide-induced LX-2 and T6 cells activation through regulation of ferroptosis.Food science & nutrition · 2023Article
- The roles of hepatokine and osteokine in liver-bone crosstalk: Advance in basic and clinical aspects.Frontiers in endocrinology · 2023Review
- Lipocalin 2 receptors: facts, fictions, and myths.Frontiers in immunology · 2023Review
- NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosis.EMBO reports · 2022Article
- Article
- Loss of FOCAD, operating via the SKI messenger RNA surveillance pathway, causes a pediatric syndrome with liver cirrhosis.Nature genetics · 2022Article
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Authors and funding
18 authors.
Jiegen Chen *Departments of Medicine and Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Josepmaria Argemi *Division of Gastroenterology, Hepatology and Nutrition, Pittsburgh Liver Research Center, University of Pittsburgh Medical Center, Pittsburgh, PA, 15213, USA.
Gemma OdenaDepartments of Medicine and Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Ming-Jiang XuLaboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health, Bethesda, DM, 20892, USA.
Yan CaiLaboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health, Bethesda, DM, 20892, USA.
Veronica MasseyDepartments of Medicine and Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Austin ParrishDepartment of Pathology, Anatomy and Cell Biology, Daniel Baugh Institute for Functional Genomics and Computational Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Rajanikanth VadigepalliDepartment of Pathology, Anatomy and Cell Biology, Daniel Baugh Institute for Functional Genomics and Computational Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Jose AltamiranoHepatology-Internal Medicine Department, Hospital Quironsalud Barcelona, Barcelona, Spain.
Joaquin CabezasGastroenterology and Hepatology Department, Research Institute Valdecilla (IDIVAL), University Hospital Marques de Valdecilla, Santander, Spain.
Pere GinesHospital Clinic, Institut D'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), CIBER de Enfermedades Hepáticas Y Digestivas (CIBERehd), Barcelona, Catalonia, Spain.
Juan CaballeriaHospital Clinic, Institut D'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), CIBER de Enfermedades Hepáticas Y Digestivas (CIBERehd), Barcelona, Catalonia, Spain.
Natasha SniderDepartment of Cell Biology and Physiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Pau Sancho-BruHospital Clinic, Institut D'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), CIBER de Enfermedades Hepáticas Y Digestivas (CIBERehd), Barcelona, Catalonia, Spain.
Shizuo AkiraLaboratory of Host Defense, Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.
Ivan RusynDepartment of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, 77843, USA.
Bin GaoLaboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health, Bethesda, DM, 20892, USA.
Ramon BatallerDepartments of Medicine and Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. bataller@pitt.edu.
Funding
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3MAlcohol Tissue InjuryT32AA007463 · NIAAA · THOMAS JEFFERSON UNIVERSITY · PI HOEK, JOANNES B, VADIGEPALLI, RAJANIKANTH · 1985 to 2021
$9.1MEthanol Effects on the Transcriptional Regulatory Network in Liver Regeneration -R01AA018873 · NIAAA · THOMAS JEFFERSON UNIVERSITY · PI SRIVASTAVA, ANKITA · 2009 to 2025
$8.7MMolecular Subtypes for Targeted Therapies in Alcoholic HepatitisU01AA021908 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BATALLER, RAMON · 2013 to 2017
$6.0MMetabolomic and Toxicogenetic Study of Ethanol ToxicityR01AA016258 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUSYN, IVAN · 2005 to 2009
$2.5MMIF in progression and treatment of ALDU01AA020821 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI NAGY, LAURA E. · 2012 to 2016
$2.1MCD73 is a multi-functional protein that regulates liver injuryR01DK110355 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SNIDER, NATASHA T · 2017 to 2021
$1.8MHepatic stellate cell microRNA networks in ethanol-impaired liver regenerationF31AA024969 · NIAAA · THOMAS JEFFERSON UNIVERSITY · PI PARRISH, AUSTIN · 2016 to 2017
$88kNCI NIH HHS P30 CA016086NIAAA NIH HHS 1U01AA021908-01NIAAA NIH HHS F31 AA024969NIAAA NIH HHS R01 AA016258NIAAA NIH HHS R01 AA018873NIAAA NIH HHS T32 AA007463NIAAA NIH HHS U01 AA020821NIAAA NIH HHS U01 AA021908NIDDK NIH HHS R01 DK110355NIEHS NIH HHS P30 ES010126
Abstract
Advanced fibrosis and portal hypertension influence short-term mortality. Lipocalin 2 (LCN2) regulates infection response and increases in liver injury. We explored the role of intrahepatic LCN2 in human alcoholic hepatitis (AH) with advanced fibrosis and portal hypertension and in experimental mouse fibrosis. We found hepatic LCN2 expression and serum LCN2 level markedly increased and correlated with disease severity and portal hypertension in patients with AH. In control human livers, LCN2 expressed exclusively in mononuclear cells, while its expression was markedly induced in AH livers, not only in mononuclear cells but also notably in hepatocytes. Lcn2
Indexed as
AnimalsCarbon TetrachlorideCollagen Type ICollagen Type I, alpha 1 ChainDisease Models, AnimalEthanolFemaleGene Expression RegulationHepatitis, AlcoholicHepatocytesHumansHypertension, PortalLipocalin-2LiverLiver CirrhosisMaleCarbon TetrachlorideCollagen Type ICollagen Type I, alpha 1 ChainEthanolLCN2 protein, humanLcn2 protein, mouseLipocalin-2Timp1 protein, mouseTissue Inhibitor of Metalloproteinase-1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.