SynthesisScientific reports2020
Evolution of outcome and complications in TAVR: a meta-analysis of observational and randomized studies.
Synthesis in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 3 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Pooled it
- Pooled it
- Ultrasound- Versus Fluoroscopy-Guided Strategy for Transfemoral Transcatheter Aortic Valve Replacement Access: A Systematic Review and Meta-Analysis.Circulation. Cardiovascular interventions · 2021Pooled it
- Development of an artificial intelligence algorithm for automated detection of cardiovascular intervention-related complications.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2026Article
- Preprocedural Biomarkers of Inflammation and Fibrosis and Echocardiographic Markers of Myocardial Remodeling in New-Onset Conduction Disorders After Transcatheter Aortic Valve Implantation.Medicina (Kaunas, Lithuania) · 2026Observational
- Ultrasound versus angiographic guided access in transfemoral TAVI: intra-operator evaluation of vascular and bleeding complications.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Annular rupture in TAVI: considerations on the importance of on-site cardiothoracic surgery.Journal of cardiothoracic surgery · 2026Article
- Prognostic utility of mid-regional pro-adrenomedullin and growth differentiation factor 15 in patients undergoing transfemoral transcatheter aortic valve implantation.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Observational
- Hydra valve with active release mechanism: GENESIS of a new contender in TAVI space.AsiaIntervention · 2025Article
- Crossover balloon occlusion technique for access closure during transcatheter aortic valve implantation: a multicenter observational study.Scientific reports · 2025Observational
- Transcatheter aortic valve replacement in low-risk patients: an updated meta-analysis of randomized controlled trials.International journal of cardiology. Heart & vasculature · 2025Article
- Safety and feasibility of early discharge after transcatheter aortic valve implantation with ACURATE Neo-the POLESTAR trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Observational
- 30-Day Transcatheter Aortic Valve Replacement Outcomes in Severe Symptomatic Aortic Stenosis Chinese Patients.JACC. Asia · 2025Article
- Impact of Right Heart Failure on Outcomes of Transcatheter Aortic Valve Implantation: Insights from the National Inpatient Sample.Journal of clinical medicine · 2025Article
- Article
- Hemodynamic effect of supra-annular implantation of SAPIEN 3 balloon expandable valve.Cardiovascular intervention and therapeutics · 2025Article
- Aortic Valve Calcium: A Narrative Review of its Role in the Assessment of Aortic Stenosis and as a Predictor of Post-transcatheter Aortic Valve Implantation Outcomes.Interventional cardiology (London, England) · 2025Review
- Contemporary Management of the Aortic Valve-Narrative Review of an Evolving Landscape.Journal of clinical medicine · 2024Review
- Stroke in Patients Undergoing Transcatheter Aortic Valve Replacement: Embracing the Unpredictable.Journal of the American Heart Association · 2024Article
- Chronic Right Ventricular Pacing Post-Transcatheter Aortic Valve Replacement Attenuates the Benefit on Left Ventricular Function.Journal of clinical medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim of the present analysis was to collect and pool all available data currently in the literature regarding outcomes and complications of all approved TAVR prosthesis and to assess the transition from first to next generation TAVR devices by directly comparing both in regard of procedure related complications. Transcatheter aortic valve replacement is a well established treatment modality in patients with severe aortic stenosis deemed to be inoperable or at unacceptable risk for open heart surgery. First generation prostheses were associated with a high rate of peri-procedural complications like paravalvular regurgitation, valve malpositioning, vascular complications and conduction disorders. Refinement of the available devices incorporate features to address the limitations of the first-generation devices. A PRISMA checklist-guided systematic review and meta-analysis of prospective observational studies, national and device specific registries or randomized clinical trials was conducted. Studies were identified by searching PUBMED, SCOPUS, Cochrane Central Register of Controlled Trials and LILACs from January 2000 to October 2017. We extracted and pooled data on both mortality and complications from 273 studies for twelve different valves prostheses in a total of 68,193 patients. In second generation prostheses as compared to first generation devices, we observed a significant decrease in mortality (1.47 ± 1.73% vs. 5.41 ± 4.35%; p < 0.001), paravalvular regurgitation (1.75 ± 2.43vs. 12.39 ± 9.38, p < 0.001) and MACE. TAVR with contemporary next generation devices has led to an impressive improvement in TAVR safety driven by refined case selection, improved procedural techniques and increased site experience.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.