ArticleScientific reports2020
Physiologic blood flow is turbulent.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 101 citations in OpenAlex.
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- A transverse picoNewton force revealed in anisotropic Womersley flow.Scientific reports · 2026Article
- Computational modeling of immersed non-spherical bodies in viscous flows to study embolus-hemodynamics interactions in large-vessel occlusion stroke.Engineering with computers · 2026Article
- Pediatric Cardiovascular Multiscale Modeling using a Functional Mock-up Interface.Cardiovascular engineering and technology · 2025Article
- Initiation of transthyretin aggregation at neutral pH by fluid agitation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Induction of Controllable Vortical Flow in a Dual-Stenosis Aorta Model: A Replication of Disordered Eddies Flow in Aneurysms.Journal of cardiovascular translational research · 2025Article
- CFD investigations of a shape-memory polymer foam-based endovascular embolization device for the treatment of intracranial aneurysms.Biomechanics and modeling in mechanobiology · 2025Article
- An in silico analysis of heart rate impact on wall shear stress hemodynamic parameters in aortic coarctation.Scientific reports · 2025Article
- The emerging challenge ofClinical microbiology reviews · 2024Review
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- Aggregation of Transthyretin by Fluid Agitation.bioRxiv : the preprint server for biology · 2024Article
- CFD investigations of a shape-memory polymer foam-based endovascular embolization device for the treatment of intracranial aneurysms.Research square · 2024Article
- Computational Fluid Dynamics (CFD) in Arteriovenous (AV) Graft Implantation Through End-to-Side Anastomosis with Varying Tube Diameters Across Different Vascular Access Locations for Dialysis Treatment.Medicina (Kaunas, Lithuania) · 2024Article
- Advances in the Computational Assessment of Disturbed Coronary Flow and Wall Shear Stress: A Contemporary Review.Journal of the American Heart Association · 2024Review
- Literature Survey for In-Vivo Reynolds and Womersley Numbers of Various Arteries and Implications for Compliant In-Vitro Modelling.Cardiovascular engineering and technology · 2024Review
- Switching to external flows: perturbations of developing vasculature within chicken chorioallantoic membrane.Lab on a chip · 2024Article
- Role of viscoelasticity in the appearance of low-Reynolds turbulence: considerations for modelling.Journal of biological engineering · 2024Review
- Article
- Uncertainty quantification of the impact of peripheral arterial disease on abdominal aortic aneurysms in blood flow simulations.Journal of the Royal Society, Interface · 2024Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Contemporary paradigm of peripheral and intracranial vascular hemodynamics considers physiologic blood flow to be laminar. Transition to turbulence is considered as a driving factor for numerous diseases such as atherosclerosis, stenosis and aneurysm. Recently, turbulent flow patterns were detected in intracranial aneurysm at Reynolds number below 400 both in vitro and in silico. Blood flow is multiharmonic with considerable frequency spectra and its transition to turbulence cannot be characterized by the current transition theory of monoharmonic pulsatile flow. Thus, we decided to explore the origins of such long-standing assumption of physiologic blood flow laminarity. Here, we hypothesize that the inherited dynamics of blood flow in main arteries dictate the existence of turbulence in physiologic conditions. To illustrate our hypothesis, we have used methods and tools from chaos theory, hydrodynamic stability theory and fluid dynamics to explore the existence of turbulence in physiologic blood flow. Our investigation shows that blood flow, both as described by the Navier-Stokes equation and in vivo, exhibits three major characteristics of turbulence. Womersley's exact solution of the Navier-Stokes equation has been used with the flow waveforms from HaeMod database, to offer reproducible evidence for our findings, as well as evidence from Doppler ultrasound measurements from healthy volunteers who are some of the authors. We evidently show that physiologic blood flow is: (1) sensitive to initial conditions, (2) in global hydrodynamic instability and (3) undergoes kinetic energy cascade of non-Kolmogorov type. We propose a novel modification of the theory of vascular hemodynamics that calls for rethinking the hemodynamic-biologic links that govern physiologic and pathologic processes.
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