ArticleNature communications2020
Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 8 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 8 pooled it
41.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
119 citing papers in PubMed, 8 syntheses or guidelines pooled it, 283 citations in OpenAlex.
- Genome wide association study meta-analysis of neuropathologic lesions of Alzheimer's disease and related dementias in a multi-site autopsy cohort.PLoS genetics · 2026Pooled it
- A Multi-Ancestry GWAS Meta-Analysis Integrated with In-Depth Silico, Systems Biology, and Pharmacogenomics Approaches on Alzheimer's Disease Among 1,198,689 Subjects.Journal of molecular neuroscience : MN · 2025Pooled it
- Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic review.PLoS genetics · 2025Pooled it
- Digital Clock Drawing as an Alzheimer's Disease Susceptibility Biomarker: Associations with Genetic Risk Score and APOE in Older Adults.The journal of prevention of Alzheimer's disease · 2024Pooled it
- Overcoming attenuation bias in regressions using polygenic indices.Nature communications · 2023Pooled it
- Multi-ancestry meta-analysis and fine-mapping in Alzheimer's disease.Molecular psychiatry · 2023Pooled it
- Fully exploiting SNP arrays: a systematic review on the tools to extract underlying genomic structure.Briefings in bioinformatics · 2022Pooled it
- Genetically regulated expression in late-onset Alzheimer's disease implicates risk genes within known and novel loci.Translational psychiatry · 2021Pooled it
- Genotypic Effects of the TOMM40'523 Variant and APOE on Longitudinal Cognitive Change over 4 Years: The TOMMORROW Study.The journal of prevention of Alzheimer's disease · 2023Trial
- Sex-specific regulation of angiogenin in Alzheimer's disease.Molecular psychiatry · 2026Article
- Parent-of-origin effects in Alzheimer's liability dissociate neurocognitive and cardiovascular traits in at-risk individuals.Cell reports. Medicine · 2026Article
- Multi-threshold polygenic risk improves hippocampal-based cognitive decline prediction.Genome medicine · 2026Article
- Polygenic Risk Scores for Incident Dementia in the Multi-Ethnic Study of Atherosclerosis.Genetic epidemiology · 2026Article
- GWAS on short tandem repeats identifies genetic mechanisms in Alzheimer's disease.Nature communications · 2026Article
- In Vivo 4D Oxy-Wavelet MRI as a Non-Invasive Biomarker of Brain Mitochondrial Function across the Lifespan.bioRxiv : the preprint server for biology · 2026Article
- Functional Analysis of Late-Onset Alzheimer's Disease Risk Genes inbioRxiv : the preprint server for biology · 2026Article
- Article
- Review
- Alzheimer's disease: genetic background in the era of next-generation sequencing technologies.Brain communications · 2026Review
- Toward personalized medicine in AD/ADRD through genetic-exposome dementia risk assessments.NPJ dementia · 2026Review
59 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 11 institutions in 3 countries.
Qian ZhangInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.
Julia SidorenkoInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.ORCID http://orcid.org/0000-0003-1494-6772
Baptiste Couvy-DuchesneInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.
Riccardo E MarioniCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Margaret J WrightQueensland Brain Institute, The University of Queensland, St Lucia, QLD, 4072, Australia.ORCID http://orcid.org/0000-0001-7133-4970
Alison M GoateDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.ORCID http://orcid.org/0000-0002-0576-2472
Edoardo MarcoraDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.ORCID http://orcid.org/0000-0002-3829-4927
Kuan-Lin HuangDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.ORCID http://orcid.org/0000-0002-5537-5817
Tenielle PorterCollaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Simon M LawsCollaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.ORCID http://orcid.org/0000-0002-4355-7082
Australian Imaging Biomarkers and Lifestyle (AIBL) Study
Perminder S SachdevCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-9595-3220
Karen A MatherCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
Nicola J ArmstrongDepartment of Mathematics and Statistics, Murdoch University, Perth, WA, Australia.
Anbupalam ThalamuthuCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
Henry BrodatyCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0001-9487-6617
Loic YengoInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.
Jian YangInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.ORCID http://orcid.org/0000-0003-2001-2474
Naomi R WrayInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.ORCID http://orcid.org/0000-0001-7421-3357
Allan F McRaeInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.
Peter M VisscherInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia. peter.visscher@uq.edu.au.ORCID http://orcid.org/0000-0002-2143-8760
The University of Melbourne · AUEdith Cowan University · AUCommonwealth Scientific and Industrial Research Organisation · AUThe University of Queensland · AUMurdoch University · AUAustin Health · AUIcahn School of Medicine at Mount Sinai · USNational Ageing Research Institute · AUUNSW Sydney · AUSt Vincent's Hospital Melbourne · AUUniversity of Edinburgh · GB
Funding
Genomic approach to identification of microglial networks involved in Alzheimer’s disease riskU01AG058635 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GOATE, ALISON M · 2018 to 2022
$4.8MIdentification and characterization of AD risk networks using multi-dimensional "omics" dataU01AG052411 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CRUCHAGA, CARLOS, GOATE, ALISON M · 2016 to 2020
$4.5MBig Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0MTransforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC SupercomputerS10OD018522 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2014 to 2014
$1.9MNIA NIH HHS U01 AG052411NIA NIH HHS U01 AG058635NIH HHS S10 OD018522NIH HHS S10 OD026880
Abstract
Genetic association studies have identified 44 common genome-wide significant risk loci for late-onset Alzheimer's disease (LOAD). However, LOAD genetic architecture and prediction are unclear. Here we estimate the optimal P-threshold (P
Indexed as
Genetic Association StudiesAdultAgedAge of OnsetAlzheimer DiseaseFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedPolymorphism, Single NucleotideRisk Factors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.