ArticleNature communications2020
REM sleep promotes experience-dependent dendritic spine elimination in the mouse cortex.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
76 citing papers in PubMed, 1 synthesis or guideline pooled it, 139 citations in OpenAlex.
- Pooled it
- Invertebrate brains as diversified models for understanding sleep mechanisms and function.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- Invertebrate brains as diversified models for understanding sleep mechanisms and function.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
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- Sleep deprivation alters hippocampal dendritic spines in a contextual fear memory engram.Scientific reports · 2026Article
- Modular inhibitory coding in binary networks.Frontiers in network physiology · 2026Article
- Functional Suppression of CLOCK Activity in Ventromedial Hypothalamic Prodynorphin Neurons Alters Locomotor Activity and Rapid Eye Movement Sleep.Neurology international · 2025Article
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- Two-factor synaptic consolidation reconciles robustness with pruning and homeostatic scaling.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Association between sleep duration at 12 and 18 months and epilepsy risk at 2-3 years: the Japan Environment and Children's Study.BMJ paediatrics open · 2025Article
- Acute REM sleep deprivation alleviated depression-like behavior mediated by inhibiting VIP neurons in the mPFC.Science advances · 2025Article
- Brief sleep disruption following hippocampus-dependent learning downscales interneuron synapses within lateral entorhinal cortex.bioRxiv : the preprint server for biology · 2025Article
- Article
- Cholinergic modulation of neural networks supports sequential and complementary roles for NREM and REM states in memory consolidation.PLoS computational biology · 2025Article
- Both slow wave and rapid eye movement sleep contribute to emotional memory consolidation.Communications biology · 2025Article
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- Illuminating the impact of stress: In vivo approaches to track stress-related neural adaptations.Neurobiology of stress · 2025Article
- Dynamic changes in cortical neurotrophic factor-positive interneurons during sleep.Scientific reports · 2025Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 7 institutions in 3 countries.
Funding
Abstract
In many parts of the nervous system, experience-dependent refinement of neuronal circuits predominantly involves synapse elimination. The role of sleep in this process remains unknown. We investigated the role of sleep in experience-dependent dendritic spine elimination of layer 5 pyramidal neurons in the visual (V1) and frontal association cortex (FrA) of 1-month-old mice. We found that monocular deprivation (MD) or auditory-cued fear conditioning (FC) caused rapid spine elimination in V1 or FrA, respectively. MD- or FC-induced spine elimination was significantly reduced after total sleep or REM sleep deprivation. Total sleep or REM sleep deprivation also prevented MD- and FC-induced reduction of neuronal activity in response to visual or conditioned auditory stimuli. Furthermore, dendritic calcium spikes increased substantially during REM sleep, and the blockade of these calcium spikes prevented MD- and FC-induced spine elimination. These findings reveal an important role of REM sleep in experience-dependent synapse elimination and neuronal activity reduction.
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Registered trials
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