Evidence map›Paper›PMID 32967936›Full record

ArticleRNA (New York, N.Y.)2020

The origin of the high stability of 3'-terminal uridine tetrads: contributions of hydrogen bonding, stacking interactions, and steric factors evaluated using modified oligonucleotide analogs.

Witold Andrałojć, Karol Pasternak, Joanna Sarzyńska, Karolina Zielińska, Ryszard Kierzek, Zofia Gdaniec

Abstract read
In one paragraph

Article in RNA (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Witold AndrałojćInstitute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland.ORCID 0000-0001-6951-2715
Karol PasternakInstitute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland.
Joanna SarzyńskaInstitute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland.ORCID 0000-0002-0500-2238
Karolina ZielińskaInstitute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland.
Ryszard KierzekInstitute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland.
Zofia GdaniecInstitute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland.ORCID 0000-0003-2955-1829

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RNA G-quadruplexes fold almost exclusively into parallel-stranded structures and thus display much less structural diversity than their DNA counterparts. However, also among RNA G-quadruplexes peculiar structural elements can be found which are capable of reshaping the physico-chemical properties of the folded structure. A striking example is provided by a uridine tetrad (U-tetrad) placed on the 3'-terminus of the tetramolecular G-quadruplex. In this context, the U-tetrad adopts a unique conformation involving chain reversal and is responsible for a tremendous stabilization of the G-quadruplex (ΔT

Indexed as

G-QuadruplexesNucleic Acid ConformationHydrogen BondingMolecular Dynamics SimulationOligonucleotidesUridineOligonucleotidesUridineG-quadruplexmolecular dynamicsNMR spectroscopyU-tetrad

Identifiers

PMID32967936
PMCPMC7668245

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.