Evidence map›Paper›PMID 32967906›Full record

ArticleDevelopment (Cambridge, England)2020

Functional evidence that Activin/Nodal signaling is required for establishing the dorsal-ventral axis in the annelid

Alexis R Lanza, Elaine C Seaver

Abstract read
In one paragraph

Article in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Early nervous system development in the chaetognathFrontiers in cell and developmental biology · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Understanding developmental system drift.Development (Cambridge, England) · 2024
    Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alexis R LanzaWhitney Laboratory for Marine Bioscience, University of Florida, 9505 Ocean Shore Boulevard, St Augustine, FL 32080-8610, USA.
Elaine C SeaverWhitney Laboratory for Marine Bioscience, University of Florida, 9505 Ocean Shore Boulevard, St Augustine, FL 32080-8610, USA seaver@whitney.ufl.edu.ORCID 0000-0002-5098-3899

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The TGF-β superfamily comprises two distinct branches: the Activin/Nodal and BMP pathways. During development, signaling by this superfamily regulates a variety of embryological processes, and it has a conserved role in patterning the dorsal-ventral body axis. Recent studies show that BMP signaling establishes the dorsal-ventral axis in some mollusks. However, previous pharmacological inhibition studies in the annelid

Indexed as

ActivinsAnimalsBody PatterningEmbryo, NonmammalianGene Expression Regulation, DevelopmentalNodal ProteinPolychaetaSignal TransductionSmad2 ProteinTransforming Growth Factor betaActivinsNodal ProteinSmad2 ProteinTransforming Growth Factor betaAnnelidAxes formationBMPMorpholinoSpiralianTGF-β

Identifiers

PMID32967906
PMCPMC7522025

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.