ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2020
Mendelian Randomization Analysis of n-6 Polyunsaturated Fatty Acid Levels and Pancreatic Cancer Risk.
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Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13citing papers in PubMed, 1 pooled it
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Systematic review of Mendelian randomization studies on risk of cancer.BMC medicine · 2022Pooled it
- Cross-population proteome-wide mendelian randomization study identifies likely causal proteins for cardiovascular diseases.Molecular genetics and genomics : MGG · 2026Article
- Investigating causal associations among inflammatory proteins, blood metabolites, and Alzheimer's disease risk.BMC psychiatry · 2026Article
- The ratio of omega-6 fatty acids to omega-3 fatty acids mediating the effect of gastroesophageal reflux disease on pancreatic cancer risk: a two-step mediation Mendelian randomisation study.BMC gastroenterology · 2025Article
- Causal Relationship Between Blood Metabolites and Prostate Cancer Risk: A Two-Sample Mendelian Randomization Study.Molecular carcinogenesis · 2025Article
- Genetically proxied risk and protective factors for pancreatic cancer: a systematic review and meta-analysis of Mendelian randomization studies.Journal of gastrointestinal oncology · 2025Article
- Assessing the influence of plasma metabolites on chronic skin ulcer risk: a two-sample Mendelian randomization study.Scientific reports · 2025Article
- Identification of blood metabolites associated with risk of Alzheimer's disease by integrating genomics and metabolomics data.Molecular psychiatry · 2024Article
- Elucidating the role of blood metabolites on pancreatic cancer risk using two-sample Mendelian randomization analysis.International journal of cancer · 2024Article
- Regulome-wide association study identifies genetically driven accessible regions associated with pancreatic cancer risk.International journal of cancer · 2024Article
- Association between human blood metabolome and the risk of hypertension.BMC genomic data · 2023Article
- The association between genetically elevated polyunsaturated fatty acids and risk of cancer.EBioMedicine · 2023Article
- Association between Arachidonic Acid and the Risk of Schizophrenia: A Cross-National Study and Mendelian Randomization Analysis.Nutrients · 2023Article
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Authors and funding
77 authors at 20 institutions in 9 countries.
Dalia H Ghoneim *Division of Cancer Epidemiology, Population Sciences in the Pacific Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, Hawaii.
Jingjing Zhu *Division of Cancer Epidemiology, Population Sciences in the Pacific Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, Hawaii.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Jirong LongDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Harvey J MurffDivision of General Internal Medicine, Department of Medicine, Vanderbilt University, Nashville, Tennessee.
Fei YeDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee.
Veronica Wendy SetiawanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Lynne R WilkensDivision of Cancer Epidemiology, Population Sciences in the Pacific Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, Hawaii.
Nikhil K KhankariDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Philip HaycockMRC Integrative Epidemiology Unit, University of Bristol, Bristol, England, United Kingdom.ORCID 0000-0001-5001-3350
Samuel O AntwiDepartment of Health Sciences Research, Mayo Clinic, Jacksonville, Florida.
Yaohua YangDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Alan A ArslanDepartments of Obstetrics and Gynecology, Population Health and Environmental Medicine, NYU Perlmutter Comprehensive Cancer Center, New York, New York.ORCID 0000-0002-7775-8085
Laura E Beane FreemanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Paige M BracciDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.
Federico CanzianGenomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-4261-4583
Mengmeng DuDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
Steven GallingerLunenfeld-Tanenbaum Research Institute, Sinai Health System and University of Toronto, Toronto, Ontario, Canada.
Graham G GilesDivision of Cancer Epidemiology, Cancer Council Victoria, Melbourne, Victoria, Australia.ORCID 0000-0003-4946-9099
Phyllis J GoodmanSWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Loïc Le MarchandDivision of Cancer Epidemiology, Population Sciences in the Pacific Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, Hawaii.
Rachel E NealeDepartment of Population Health, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Ghislaine SceloInternational Agency for Research on Cancer, Lyon, France.
Kala VisvanathanDepartment of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland.ORCID 0000-0002-0582-8005
Emily WhiteCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Pilar AmianoMinistry of Health of the Basque Government, Public Health Division of Gipuzkoa, Biodonostia Health Research Institute, Donostia-San Sebastian; CIBER Epidemiología y Salud Pública, Madrid, Spain.
Gabriella AndreottiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Ana BabicDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
William R BamletDepartment of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota.ORCID 0000-0003-2903-1284
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Lauren K BraisDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Paul BrennanInternational Agency for Research on Cancer, Lyon, France.ORCID 0000-0002-0518-8714
Bas Bueno-de-MesquitaDepartment for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Julie E BuringDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Peter T CampbellBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia.
Kari G RabeDepartment of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota.ORCID 0000-0002-7313-1875
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Priya DuggalDepartment of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland.
Charles S FuchsYale Cancer Center, New Haven, Connecticut.
J Michael GazianoDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Michael G GogginsDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, Maryland.
Thilo HackertDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0002-7012-1196
Manal M HassanDepartment of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Kathy J HelzlsouerEpidemiology and Genomics Research Program, Division of Cancer Control and Population Science, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Elizabeth A HollyDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.
Robert N HooverDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Verena KatskeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-6509-6555
Robert C KurtzGastroenterology, Hepatology, and Nutrition Service, Memorial Sloan Kettering Cancer Center, New York, New York.
I-Min LeeDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Núria MalatsGenetic and Molecular Epidemiology Group, Spanish National Cancer Research Center, Madrid, Spain.ORCID 0000-0003-2538-3784
Roger L MilneDivision of Cancer Epidemiology, Cancer Council Victoria, Melbourne, Victoria, Australia.ORCID 0000-0001-5764-7268
Neil MurphySection of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.
Ann L ObergDepartment of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota.ORCID 0000-0003-2539-9807
Miquel PortaHospital del Mar Institute of Medical Research (IMIM), Universitat Autònoma de Barcelona, Barcelona, Spain.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Howard D SessoDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.ORCID 0000-0002-9698-9954
Debra T SilvermanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Ian M ThompsonCHRISTUS Santa Rosa Hospital - Medical Center, San Antonio, Texas.
Jean Wactawski-WendeDepartment of Epidemiology and Environmental Health, University of Buffalo, Buffalo, New York.ORCID 0000-0003-3096-9595
Xiaoliang WangCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Nicolas WentzensenDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Herbert YuDivision of Cancer Epidemiology, Population Sciences in the Pacific Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, Hawaii.ORCID 0000-0003-3950-4815
Anne Zeleniuch-JacquotteDepartments of Population Health and Environmental Medicine, NYU Perlmutter Comprehensive Cancer Center, New York, New York.
Kai YuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0003-3950-4815
Brian M WolpinDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Eric J JacobsEpidemiology Research Program, American Cancer Society, Atlanta, Georgia.ORCID 0000-0001-5256-0163
Eric J DuellUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute (IDIBELL), Catalan Institute of Oncology (ICO), Barcelona, Spain.
Harvey A RischDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut.
Gloria M PetersenDepartment of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota.
Laufey T AmundadottirLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0003-1859-8971
Peter KraftDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusetts.
Alison P KleinDepartment of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland.ORCID 0000-0003-2737-8399
Rachel Z Stolzenberg-SolomonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee. lwu@cc.hawaii.edu xiao-ou.shu@vanderbilt.edu.
Lang WuDivision of Cancer Epidemiology, Population Sciences in the Pacific Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, Hawaii. lwu@cc.hawaii.edu xiao-ou.shu@vanderbilt.edu.
National Cancer Institute · USUniversity of Hawaiʻi at Mānoa · USVanderbilt University Medical Center · USBrigham and Women's Hospital · USFred Hutch Cancer Center · USMayo Clinic · USBloomberg (United States) · USCentre international de recherche sur le cancer · FRDana-Farber Cancer Institute · USAmerican Cancer Society · USGerman Cancer Research Center · DEMemorial Sloan Kettering Cancer Center · USNew York University · USThe University of Melbourne · AUUniversity of California, San Francisco · USBasque Government · ESChristus Santa Rosa Health System · USHeidelberg University · DEInstitut d'Investigació Biomédica de Bellvitge · ESJacksonville College · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MSWOG Foreign AccrualsU10CA037429 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BLANKE, CHARLES D., MEYSKENS, FRANK L. · 1985 to 2014
$205.2MSWOG NCORP Research BaseUG1CA189974 · NCI · THE HOPE FOUNDATION · PI CHARLES D. BLANKE, DAWN HERSHMAN · 2014 to 2026
$80.6MUniversity of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Xin Chen · 1996 to 2026
$56.2MTumor Antigens for Individual Signatures and TherapyP50CA062924 · NCI · JOHNS HOPKINS UNIVERSITY · PI LENNON, ANNE MARIE · 1993 to 2022
$54.6MUnderstanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9MData sharing: the Colon Cancer Family Registry CohortU01CA167551 · NCI · UNIVERSITY OF MELBOURNE · PI Daniel David BUCHANAN, Steven Gallinger · 2018 to 2026
$16.8MONTARIO REGISTRY FOR STUDIES OF FAMILIAL COLON CANCERU01CA074783 · NCI · CANCER CARE ONTARIO · PI GALLINGER, STEVEN · 1997 to 2008
$12.5MValidation and Fine-Scale Mapping of Pancreatic Cancer Susceptibility Loci (Study)R01CA154823 · NCI · JOHNS HOPKINS UNIVERSITY · PI KLEIN, ALISON P · 2011 to 2020
$5.7MPCPT and SELECT Cohorts: Core Infrastructure Support for Cancer ResearchU01CA182883 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI TANGEN, CATHERINE M., THOMPSON, IAN M. · 2019 to 2023
$5.4MCase-Control Study of Pancreas Cancer Etiologic FactorsR01CA098870 · NCI · YALE UNIVERSITY · PI RISCH, HARVEY A · 2003 to 2008
$3.5MCancer Research UK 19169Cancer Research UK 20138Cancer Research UK 29019NCI NIH HHS K01 CA237875NCI NIH HHS K99 CA218892NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA071789NCI NIH HHS P50 CA062924NCI NIH HHS R00 CA218892NCI NIH HHS R01 CA098870NCI NIH HHS R01 CA154823NCI NIH HHS U01 CA074783NCI NIH HHS U01 CA164973NCI NIH HHS U01 CA167551NCI NIH HHS U01 CA182883NCI NIH HHS U01 CA182934NCI NIH HHS U01 CA247283NCI NIH HHS U10 CA037429NCI NIH HHS UG1 CA189974NHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNIDDK NIH HHS P30 DK058404World Health Organization 001
Abstract
backgroundWhether circulating polyunsaturated fatty acid (PUFA) levels are associated with pancreatic cancer risk is uncertain. Mendelian randomization (MR) represents a study design using genetic instruments to better characterize the relationship between exposure and outcome.
methodsWe utilized data from genome-wide association studies within the Pancreatic Cancer Cohort Consortium and Pancreatic Cancer Case-Control Consortium, involving approximately 9,269 cases and 12,530 controls of European descent, to evaluate associations between pancreatic cancer risk and genetically predicted plasma n-6 PUFA levels. Conventional MR analyses were performed using individual-level and summary-level data.
resultsUsing genetic instruments, we did not find evidence of associations between genetically predicted plasma n-6 PUFA levels and pancreatic cancer risk [estimates per one SD increase in each PUFA-specific weighted genetic score using summary statistics: linoleic acid odds ratio (OR) = 1.00, 95% confidence interval (CI) = 0.98-1.02; arachidonic acid OR = 1.00, 95% CI = 0.99-1.01; and dihomo-gamma-linolenic acid OR = 0.95, 95% CI = 0.87-1.02]. The OR estimates remained virtually unchanged after adjustment for covariates, using individual-level data or summary statistics, or stratification by age and sex.
conclusionsOur results suggest that variations of genetically determined plasma n-6 PUFA levels are not associated with pancreatic cancer risk. IMPACT: These results suggest that modifying n-6 PUFA levels through food sources or supplementation may not influence risk of pancreatic cancer.
Indexed as
AgedFatty Acids, Omega-6FemaleHumansMaleMendelian Randomization AnalysisMiddle AgedPancreatic NeoplasmsRisk FactorsFatty Acids, Omega-6
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