Evidence map›Paper›PMID 32967771›Full record

ArticlePathology2021

Prognostic features of Annexin A2 expression in prostate cancer.

Shyh-Han Tan, Denise Young, Yongmei Chen, Huai-Ching Kuo, Alagarsamy Srinivasan, Albert Dobi, Gyorgy Petrovics, Jennifer Cullen, David G Mcleod, Inger L Rosner and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Cancers · 2025
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  17. (20S) Ginsenoside Rh2 Inhibits STAT3/VEGF Signaling by Targeting Annexin A2.International journal of molecular sciences · 2021
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Shyh-Han TanHenry Jackson Foundation for the Advancement of Military Medicine (HJF), Bethesda, MD, USA; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, and the Walter Reed National Military Medical Center, Bethesda, MD, USA; Murtha Cancer Center Research Program, Walter Reed National Military Medical Center, Bethesda, MD, USA. Electronic address: stan@cpdr.org.
Denise YoungHenry Jackson Foundation for the Advancement of Military Medicine (HJF), Bethesda, MD, USA; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, and the Walter Reed National Military Medical Center, Bethesda, MD, USA; Murtha Cancer Center Research Program, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Yongmei ChenHenry Jackson Foundation for the Advancement of Military Medicine (HJF), Bethesda, MD, USA; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, and the Walter Reed National Military Medical Center, Bethesda, MD, USA; Murtha Cancer Center Research Program, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Huai-Ching KuoHenry Jackson Foundation for the Advancement of Military Medicine (HJF), Bethesda, MD, USA; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, and the Walter Reed National Military Medical Center, Bethesda, MD, USA; Murtha Cancer Center Research Program, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Alagarsamy SrinivasanHenry Jackson Foundation for the Advancement of Military Medicine (HJF), Bethesda, MD, USA; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, and the Walter Reed National Military Medical Center, Bethesda, MD, USA; Murtha Cancer Center Research Program, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Albert DobiHenry Jackson Foundation for the Advancement of Military Medicine (HJF), Bethesda, MD, USA; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, and the Walter Reed National Military Medical Center, Bethesda, MD, USA; Murtha Cancer Center Research Program, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Gyorgy PetrovicsHenry Jackson Foundation for the Advancement of Military Medicine (HJF), Bethesda, MD, USA; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, and the Walter Reed National Military Medical Center, Bethesda, MD, USA; Murtha Cancer Center Research Program, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Jennifer CullenHenry Jackson Foundation for the Advancement of Military Medicine (HJF), Bethesda, MD, USA; Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, and the Walter Reed National Military Medical Center, Bethesda, MD, USA; Murtha Cancer Center Research Program, Walter Reed National Military Medical Center, Bethesda, MD, USA.
David G McleodCenter for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, and the Walter Reed National Military Medical Center, Bethesda, MD, USA; Murtha Cancer Center Research Program, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Inger L RosnerCenter for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, and the Walter Reed National Military Medical Center, Bethesda, MD, USA; Murtha Cancer Center Research Program, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Shiv SrivastavaCenter for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, and the Walter Reed National Military Medical Center, Bethesda, MD, USA; Murtha Cancer Center Research Program, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Isabell A SesterhennJoint Pathology Center, Silver Spring, MD, USA.
Henry M. Jackson Foundation · USUniformed Services University of the Health Sciences · US

Funding

Cell Specific Expression Signatures in Prostate Cancer (RO1 DK065977)R01CA162383 · NCI · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI SRIVASTAVA, SHIV · 2011 to 2015
$1.1M
NCI NIH HHS R01 CA162383
6 · The paper itself

Abstract

ANXA2 (Annexin A2 or Annexin II) is a calcium dependent phospholipid binding protein with diverse cellular functions. While ANXA2 is either absent or expressed focally in the prostate epithelium of well and moderately differentiated tumours, it is highly expressed in a subset of poorly differentiated tumours. Here we examined the association between ANXA2 expression and tumour progression, with consideration of ERG expression status and patient race (Caucasian American and African American). We evaluated ANXA2 and ERG expression in index tumours by immunohistochemistry of whole mounted prostate sections and tissue microarrays derived from radical prostatectomies of 176 patients, matched for long term post-radical prostatectomy follow-up of up to 22 years (median 12.6 years), race and pathological stage. Expression of ERG and ANXA2 was analysed for correlation with grade group (GG), and pathological T (pT) stage. Kaplan-Meier estimation curves were used to examine associations between ANXA2 or ERG expression and biochemical recurrence (BCR) free survival, and distant metastasis free survival. Significant associations were found between ANXA2(+) index tumours and poorest grade groups (GG 4-5, p=0.0037), and worse pathological stage (pT 3-4, p=0.0142). Patients with ANXA2(+) prostate tumours showed trends towards earlier BCR and metastatic progression. ANXA2(+)/ERG(-) tumours were found to be associated with GG 4-5; ANXA2(-)/ERG(+) tumours, with GG 1-2 (p=0.0036). ANXA2 expression was not associated with patient race. The association between high ANXA2 expression and prostate tumours of higher grade (GG 4-5) and stage (pT 3-4) suggests a potential use for ANXA2 as a prognostic biomarker of aggressive prostate cancer.

Indexed as

Annexin A2PrognosisProstatic NeoplasmsBiomarkers, TumorDisease ProgressionHumansImmunohistochemistryKaplan-Meier EstimateMaleMiddle AgedNeoplasm GradingNeoplasm StagingProstateTranscriptional Regulator ERGAnnexin A2Biomarkers, TumorTranscriptional Regulator ERGAnnexin A2cancer health disparityprognostic biomarkerProstate cancertumour differentiation

Identifiers

PMID32967771
PMCPMC7855416
OpenAlexW3088724048

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.