GuidelineBMC pediatrics2020
Clinical practice guideline on the prevention and management of neonatal extravasation injury: a before-and-after study design.
Guideline in BMC pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04321447 (Clinical Practice Guideline on the Prevention and Management of Neonatal Extravasation Injury), which is not on this map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Practice Guideline on the Prevention and Management of Neonatal Extravasation Injury
Who cites it
12 citing papers in PubMed, 50 citations in OpenAlex.
- Guides, algorithms and other support tools to improve neonatal and pediatric venous access care: A scoping review.Journal of hospital medicine · 2026Article
- Impact of an Educational Intervention on Nurses' Knowledge of Port Catheter Management: A Quasi-Experimental Pre-Post Study.Healthcare (Basel, Switzerland) · 2026Article
- Detection of peripheral infusion-related infiltration and extravasation in neonates: a scoping review.Pediatric research · 2026Article
- Effect of scenario-supported training on pediatric nurses' knowledge and skills in extravasation and infiltration management.Frontiers in pediatrics · 2025Article
- Peripheral intravenous therapy infiltration and extravasation (PIVIE) risks in 11 006 paediatric surgery inpatients in China: a retrospective observational study.The Journal of international medical research · 2024Observational
- The effects of temperament type on infusion extravasation in newborns.Scientific reports · 2024Article
- Exploring Extravasation in Cancer Patients.Cancers · 2024Review
- Evolution of Scientific Production on Phlebitis Secondary to Vascular Access: A 71-Year Bibliometric Analysis.Nursing reports (Pavia, Italy) · 2023Review
- Reply to the Comment on "Sensing Technologies for Extravasation Detection: A Review".ACS sensors · 2023Article
- A new approach to skin extravasation injury management during the neonatal period.BMC pediatrics · 2022Article
- Case Series of Neonatal Extravasation Injury: Importance of Early Identification and Management.Cureus · 2022Article
- Clinical Practice Guideline for the Management of Non-chemotherapeutic Extravasation: A Multidisciplinary Delphi-driven Consensus Study.Iranian journal of pharmaceutical research : IJPRArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExtravasation injury resulting from intravenous therapies delivered via peripheral intravenous catheters or umbilical and peripherally inserted central venous catheters is a common iatrogenic complication occurring in neonatal intensive care units. This study aimed to evaluate the effectiveness of an evidence-based clinical practice guideline in the prevention and management of neonatal extravasation injury by nurses.
methodsA controlled before-and-after study was conducted in a neonatal unit. The clinical practice guideline was developed, and a multifaceted educational program was delivered to nurses. Neonatal outcomes, including the rates of peripheral intravenous extravasation and extravasation from a central line, were collected at the pre- and post-intervention periods. Post-intervention data for nurses, including the nurses' level of knowledge and adherence, were collected at six months after the program.
results104 and 109 neonates were recruited in the pre-intervention period (control) and the post-intervention period (intervention), respectively. The extravasation rate before and after the intervention was 14.04 and 2.90 per 1,000 peripheral intravenous catheters days, respectively. The adjusted odds ratio of peripheral intravenous extravasation post-intervention compared with that of pre-intervention was 0.20 (95% confidence interval: 0.05-0.74; p = 0.02) after adjusting for peripheral intravenous catheter days. The extravasation from a central line rate of the control and intervention groups post-intervention was 4.94 and zero per 1,000 central venous catheter days, respectively. Fifty-nine registered nurses were recruited. At six months post-program, there were significant improvements in the nurses' level of knowledge and adherence.
conclusionsThese findings suggest that the implementation of an evidence-based clinical practice guideline significantly reduced the rate of peripheral intravenous extravasation and extravasation from a central line in neonates. However, to maintain nurses' knowledge and adherence to the evidence-based practice, the educational program will have to be conducted periodically and incorporated into the nurses' induction program.
trial registrationClinicalTrials.gov, Identifiers: NCT04321447 . Registered 20 March 2020 - Retrospectively registered.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.