Observational studyBMC nephrology2020
Symptom-burden in people living with frailty and chronic kidney disease.
Observational study in BMC nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Home-based exercise for people living with frailty and chronic kidney disease: A mixed-methods pilot randomised controlled trial.PloS one · 2021Trial
- Systematic Review of Exercise Interventions and HRQOL in Predialysis CKD.Kidney international reports · 2026Article
- Recommendations for the management of frailty in chronic kidney disease: a consensus report.Nature reviews. Nephrology · 2026Review
- Functional Predictors of Frailty and Kidney Disease Burden in Patients with End-stage Renal Disease Receiving Dialysis.Journal of frailty, sarcopenia and falls · 2026Article
- Bayesian Analysis of Frailty Risk Factors in Chronic Kidney Disease: A Nationwide Cross-Sectional Survey.Health science reports · 2026Article
- Exploring factors associated with Kidney Disease Quality of Life in patients with advanced chronic kidney disease: the Reach-J CKD cohort study.Clinical and experimental nephrology · 2025Article
- Frailty in Kidney Disease: A Comprehensive Review to Advance Its Clinical and Research Applications.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025Review
- Article
- A national survey of current rehabilitation service provisions for people living with chronic kidney disease in the UK: implications for policy and practice.BMC nephrology · 2024Article
- Development of a Conceptual Model of Physical Functioning Limitations Experienced by Patients with Late-Stage Chronic Kidney Disease: A Qualitative Interview Study.Advances in therapy · 2024Article
- Frailty and Increased Levels of Symptom Burden Can Predict the Presence of Each Other in HNSCC Patients.Journal of clinical medicine · 2023Article
- Article
- Use of frailty assessment instruments in nephrology populations: a scoping review.BMC geriatrics · 2023Article
- Home dialysis in older adults: challenges and solutions.Clinical kidney journal · 2023Article
- Patient and physician perspectives on treatment burden in end-stage kidney disease: a nominal group technique study.BMJ open · 2022Article
- Article
- Associations between frailty trajectories and cardiovascular, renal, and mortality outcomes in chronic kidney disease.Journal of cachexia, sarcopenia and muscle · 2022Article
- [Long-term physical and psychological consequences of chronic kidney disease].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2022Review
- Health Literacy and Change in Health-Related Quality of Life in Dialysed Patients.International journal of environmental research and public health · 2022Article
- Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundFrailty is independently associated with worse health-related quality of life (HRQOL) in chronic kidney disease (CKD). However, the relationship between frailty and symptom experience is not well described in people living with CKD. This study's aim was to evaluate the relationship between frailty and symptom-burden in CKD.
methodsThis study is a secondary analysis of a cross-sectional observational study, the QCKD study (ISRCTN87066351), in which participants completed physical activity, cardiopulmonary fitness, symptom-burden and HRQOL questionnaires. A modified version of the Frailty Phenotype, comprising 3 self-report components, was created to assess frailty status. Multiple linear regression was performed to assess the association between symptom-burden/HRQOL and frailty. Logistic regression was performed to assess the association between experiencing symptoms frequently and frailty. Principal Component Analysis was used to assess the experienced symptom clusters.
resultsA total of 353 patients with CKD were recruited with 225 (64%) participants categorised as frail. Frail participants reported more symptoms, had higher symptom scores and worse HRQOL scores. Frailty was independently associated with higher total symptom score and lower HRQOL scores. Frailty was also independently associated with higher odds of frequently experiencing 9 out of 12 reported symptoms. Finally, frail participants experienced an additional symptom cluster that included loss of appetite, tiredness, feeling cold and poor concentration.
conclusionsFrailty is independently associated with high symptom-burden and poor HRQOL in CKD. Moreover, people living with frailty and CKD have a distinctive symptom experience. Proactive interventions are needed that can effectively identify and address problematic symptoms to mitigate their impact on HRQOL.
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