ArticleThe Journal of international medical research2020
Dexmedetomidine is superior to midazolam for sedation and cerebral protection in postoperative hypertensive intracerebral hemorrhage patients: a retrospective study.
Article in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Effect of dexmedetomidine on cerebral homeostasis in patients undergoing craniotomy for brain tumour excision: A randomized double-blind trial.British journal of clinical pharmacology · 2026Trial
- Variations in the clinical practice of blood pressure and sedo-analgesia management for intracerebral hemorrhage: a case-based survey of Chinese healthcare workers.BMC neurology · 2025Article
- Effect of early stepwise controlled decompression combined with mild hypothermia therapy on efficacy, cerebral edema volume, and serum biochemical indices in patients with severe hypertensive intracerebral hemorrhage.American journal of translational research · 2025Article
- Effects of Dexmedetomidine on Cognitive Function, Oxidative Stress and Brain Protection in Patients Undergoing Craniocerebral Surgery.Actas espanolas de psiquiatria · 2024Article
- Modern Sedation and Analgesia Strategies in Neurocritical Care.Current neurology and neuroscience reports · 2023Review
- Value of inflammatory mediator profiles and procalcitonin in predicting postoperative infection in patients with hypertensive cerebral hemorrhage.World journal of clinical cases · 2022Article
- Analysis of the Therapeutic Effect and Prognostic Factors of 126 Patients With Hypertensive Cerebral Hemorrhage Treated by Soft-Channel Minimally Invasive Puncture and Drainage.Frontiers in surgery · 2022Article
- S100B Levels Following Administration of Thiopental and Fentanyl Midazolam Combination in Patients Undergoing Mechanical Ventilation: A Comparative Study.Iranian journal of pharmaceutical research : IJPRArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDexmedetomidine has a good sedative effect and does not affect the judgment of the patient's consciousness level. However, its effectiveness for sedation and cerebral protection after craniotomy in hypertensive intracerebral hemorrhage (HICH) patients is unknown.
methodsA retrospective study of 164 postoperative HICH patients who underwent sedation with dexmedetomidine or midazolam was conducted. The Ramsay sedation score, mean arterial pressure (MAP), heart rate (HR), pulse oxygen saturation (SpO
resultsDexmedetomidine treatment showed a significantly better effect than midazolam on decreasing the frequency of apparent agitation. The MAP and HR, but not the SpO
conclusionsDexmedetomidine is effective for sedation in postoperative HICH patients and may be beneficial for their outcome.
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Registered trials
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