Evidence map›Paper›PMID 32967377›Full record

ArticleCancers2020

Computer Extracted Features from Initial H&E Tissue Biopsies Predict Disease Progression for Prostate Cancer Patients on Active Surveillance.

Sacheth Chandramouli, Patrick Leo, George Lee, Robin Elliott, Christine Davis, Guangjing Zhu, Pingfu Fu, Jonathan I Epstein, Robert Veltri, Anant Madabhushi

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. AI Model for Prostate Biopsies Predicts Cancer Survival.Diagnostics (Basel, Switzerland) · 2022
    Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Sacheth ChandramouliDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Patrick LeoDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
George LeeDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Robin ElliottDepartment of Anatomic Pathology, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.
Christine DavisDepartment of Surgical Pathology, The Johns Hopkins Hospital, 1800 Orleans St, Baltimore, MD 21287, USA.
Guangjing ZhuDepartment of Surgical Pathology, The Johns Hopkins Hospital, 1800 Orleans St, Baltimore, MD 21287, USA.
Pingfu FuDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA.
Jonathan I EpsteinDepartment of Surgical Pathology, The Johns Hopkins Hospital, 1800 Orleans St, Baltimore, MD 21287, USA.
Robert VeltriDepartment of Urology and Oncology, The Johns Hopkins University, Baltimore, MD 21287, USA.
Anant MadabhushiDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0002-5741-0399
Case Western Reserve University · USJohns Hopkins Hospital · USJohns Hopkins University · USLouis Stokes Cleveland VA Medical Center · USUniversity Hospitals of Cleveland · US

Funding

ConProject-002U2CDK114886 · NIDDK · UNIVERSITY OF WASHINGTON · PI KRETZLER, MATTHIAS · 2017 to 2021
$21.0M
Computerized histologic image predictor of cancer outcomeR01CA202752 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI FELDMAN, MICHAEL D, GANESAN, SHRIDAR · 2016 to 2020
$3.1M
Quantitative Histomorphometric Risk Classifier (QuHbIC) in HPV + Oropharyngeal CarcinomaR01CA220581 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI KOYFMAN, SHLOMO, LEWIS, JAMES · 2018 to 2023
$3.1M
Computerized Histologic Risk Predictor (CHiRP) for Early Stage Lung CancersR01CA216579 · NCI · EMORY UNIVERSITY · PI FU, PINGFU, LLOYD, MARK · 2018 to 2023
$3.1M
MR Fingerprinting and Computerized Decision Support for Prostate CancerR01CA208236 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GULANI, VIKAS, PONSKY, LEE EVAN · 2017 to 2022
$3.0M
Pathology Image Informatics Platform for visualization, analysis and managementU24CA199374 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI GURCAN, METIN NAFI, MADABHUSHI, ANANT · 2015 to 2019
$2.9M
RadxTools for assessing tumor treatment response on imagingU01CA248226 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI TIWARI, PALLAVI, VISWANATH, SATISH EASWAR · 2020 to 2022
$1.4M
HistoTools: A suite of digital pathology tools for quality control, annotation and dataset identificationU01CA239055 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI JANOWCZYK, ANDREW ROBERT, MADABHUSHI, ANANT · 2019 to 2022
$1.0M
BIOMEDICAL ENGINEERING RESEARCH FACILITIESC06RR012463 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI KUTINA, KENNETH L · 1997 to 1997
–
CWRU Nephrology Training Grant, Neptune Career Development Award 5T32DK747033National Institute for Biomedical Imaging and Bioengineering 1R43EB028736-01National Science Foundation Graduate Research Fellowship Program CON501692NCI NIH HHS 1U01 CA239055-01NCI NIH HHS 1U01CA248226-01NCI NIH HHS 1U24CA199374-01NCI NIH HHS R01CA202752-01A1NCI NIH HHS R01CA208236-01A1NCI NIH HHS R01 CA216579-01A1NCI NIH HHS R01 CA220581-01A1NCI NIH HHS U01 CA248226NCRR NIH HHS 1 C06 RR12463-01NIDDK NIH HHS U2C DK114886The DoD Breast Cancer Research Program Breakthrough Level 1 Award W81XWH-19-1-0668The DOD Lung Cancer Investigator-Initiated Translational Research Award W81XWH-18-1-0440The DOD Peer Reviewed Cancer Research Program W81XWH-16-1-0329The DOD Prostate Cancer Idea Development Award W81XWH-15-1-0558The Kidney Precision Medicine Project (KPMP) Glue Grant N/AThe Ohio Third Frontier Technology Validation Fund N/AThe Wallace H. Coulter Foundation Program in the Department of Biomedical Engineering and The Clinical and Translational Science Award Program (CTSA) at Case Western Reserve University N/AUnited States Department of Veterans Affairs Biomedical Laboratory Research and Development Service IBX004121A
6 · The paper itself

Abstract

In this work, we assessed the ability of computerized features of nuclear morphology from diagnostic biopsy images to predict prostate cancer (CaP) progression in active surveillance (AS) patients. Improved risk characterization of AS patients could reduce over-testing of low-risk patients while directing high-risk patients to therapy. A total of 191 (125 progressors, 66 non-progressors) AS patients from a single site were identified using The Johns Hopkins University's (JHU) AS-eligibility criteria. Progression was determined by pathologists at JHU. 30 progressors and 30 non-progressors were randomly selected to create the training cohort D

Indexed as

active surveillancemachine learningpathologyprostate cancer

Identifiers

PMID32967377
PMCPMC7563653
OpenAlexW3087491309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.